Clinical trials: Chronic Obstructive Airway Disease
Chronic Obstructive Pulmonary Disease
Innate Immunity in COPD
Chronic Obstructive Pulmonary Disease (COPD) causes obstruction to airflow when breathing out. It is a leading cause of chronic lung disease, hospitalization and death.
- Trial name
- NCT05743582
- Testing
- Bronchoscopy for sample collection, Blood donation
- Where
- 2 sites in United Kingdom
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
COPD, Asthma
Pathogenetic Mechanisms of Chronic Obstructive Pulmonary Diseases
Asthma and chronic obstructive pulmonary disease(COPD) are common diseases, which tend to even increase in many countries. Both from a clinical and a pathophysiological point of view, this is an important issue.
- Trial name
- CAPTA (NCT01378039)
- Testing
- comparison of treatment effect on different markers
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Fraility, COPD (Chronic Obstructive Pulmonary Disease)
Respiratory Exercises in Frail Elderly COPD Patients
Purpose: This study evaluated the impact of a structured intervention on frailty, lung function, physical capacity, and dyspnea in elderly COPD patients.
- Conditions
- Fraility, COPD (Chronic Obstructive Pulmonary Disease), Older Adults (65 Years and Older)
- Trial name
- NCT07472530
- Testing
- breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Cyclosporine Drug Interaction on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers. Drug-Drug Interaction 2 (DDI2) Study
The main goal of this pharmacokinetic study in healthy volunteers is to evaluate the potential effect of cyclosporine (probe inhibitor of P glycoprotein [P-gp] and breast cancer resistance protein [BCRP] transporters) on CHF6001…
- Trial name
- DDI2 (NCT06892756)
- Testing
- CHF6001 dry powder inhaler (DPI), Cyclosporine, CHF6001 DPI
- Where
- Bulgaria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Disease
Short Chain Fatty Acid Metabolism in COPD
The short chain fatty acid (SCFA) metabolism has not been studied in subjects suffering from COPD. The purpose of this study is to compare the SCFA metabolism in COPD patients to healthy matched controls.
- Trial name
- SCFA (NCT03327181)
- Testing
- short chain fatty acid tracers
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Asthma, Reactive Airway Disease
Comparison of Asthma Programs for Schools
The purpose was to evaluate effectiveness and impact of an academic and counseling asthma health education program (SHARP) for fourth- and fifth-grade students diagnosed with asthma.
- Trial name
- CAPS (NCT01625364)
- Testing
- SHARP program, Open Airways for Schools
- Where
- United States
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Chronic Obstructive Pulmonary Disease, Bronchial Asthma
Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing
Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF).
- Conditions
- Chronic Obstructive Pulmonary Disease, Bronchial Asthma, Restrictive Pulmonary Disease
- Trial name
- NCT01762917
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Chronic Obstructive Pulmonary Disease, Healthy
Effect of Two Physical Training Programs on Oxygen Uptake and Heart Rate On-kinetics in Patients COPD
Patients with chronic obstructive pulmonary disease (COPD) present slowed pulmonary oxygen uptake (VO2) and heart rate (HR) kinetics compared with age-matched controls.
- Trial name
- BVPS-123 (NCT01529489)
- Testing
- Resisted/Aerobic physical training, Interval physical training in elliptical equipament
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
COPD
Effects of Low-Dose Theophylline During Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Molecular mechanisms of COPD exacerbations and the modulating effect of low dose theophylline on that inflammation are elucidated in this project.
- Trial name
- NCT00671151
- Testing
- Theophylline
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Son Dureta
Asthma, COPD
Chronic Obstructive Pulmonary Disease and Asthma in Workers at Navanakorn Industrial Zone, Thailand
The goal of this observational study is to determine the prevalence of asthma and chronic obstructive pulmonary disease (COPD) among workers in an industrial zone in Thailand.
- Trial name
- NCT07383896
- Testing
- Pulmonary function test
- Where
- Thailand
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Pulmonary Disease, Chronic Obstructive
The Nasal Airway in Chronic Obstructive Pulmonary Disease
The study is based on the theory of a "unified airway" that considers the nose and paranasal sinuses together with lower airways as one integrated unit.
- Trial name
- COPD (NCT02826954)
- Testing
- Upper airway assessment, including nasal biopsy
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
COPD, Chronic Obstructive Pulmonary Disease
Study of COPD Subgroups and Biomarkers
SPIROMICS I, SPIROMICS II, and SPIROMICS III are longitudinal observational studies of Chronic Obstructive Pulmonary Disease (COPD) cohort.
- Conditions
- COPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
- Trial name
- SPIROMICS (NCT01969344)
- Where
- 14 sites in United States
- Volunteers
- 2,981 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Obstructive Pulmonary Disease (COPD)
Developing a COPD Case Finding Methodology for Primary Care
The purpose of this qualitative work is to inform the content and structure of a new screening measure for identifying undiagnosed at-risk COPD cases in primary care and support content validity of the measure.
- Trial name
- NCT01880177
- Where
- 4 sites in United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Obstructive Pulmonary Disease
Oral Supplement and Acute Resistance Exercise
This study should provide the mechanistic basis for and evaluation of a new nutritional formulation to be used alongside exercise training to improve muscle function and exercise performance by minimizing exercise induced…
- Trial name
- HMB exercise (NCT06801951)
- Testing
- acute resistance exercise with oral nutrition supplementation, stable tracer infusion
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
COPD, Emphysema
Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease
The aim of this study is to investigate the mechanisms whereby lung function is decreased in COPD. The hypothesis is that in diseases such as COPD, inflammatory cells including neutrophils, macrophages and lymphocytes migrate to…
- Trial name
- NCT00147095
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Lung Diseases, Lung Diseases, Obstructive
French Validation of the CAPTURE Case Finding Tool for Obstructive Respiratory Disease
The objective of this multicentre prospective study is to validate CAPTURE as a French case finding tool for undiagnosed patients suffering from obstructive pulmonary disease.
- Conditions
- Lung Diseases, Lung Diseases, Obstructive, Obstructive Pulmonary Disease
- Trial name
- NCT05654597
- Testing
- CAPTURE tool, Spirometry
- Where
- France
- Volunteers
- 1,002 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier du Havre
Chronic Obstructive Pulmonary Disease
Effects of the Breathe Technologies Ventilation System in Subjects With Chronic Obstructive Pulmonary Disease
Pilot study in 15 stable male subjects with severe-to-very severe Chronic Obstructive Pulmonary Disease (COPD) to evaluate the effects of short term use of the Breathe Technologies noninvasive open ventilation (NIOV) system on…
- Trial name
- NCT01372462
- Testing
- NIOV - Room Air, NIOV - Oxygen, Nasal Cannula Oxygen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Breathe Technologies, Inc.
Pulmonary Disease, Chronic Obstructive
Prevalence of Chronic Airway Obstruction in Subjects With a History of Cigarette Smoking in a Primary Care Setting
This is a cross-sectional study to determine the prevalence of symptomatic airway obstruction using the LFQ as a screening tool in primary care patients with a history of cigarette smoking and to provide descriptive data of this…
- Trial name
- NCT01013948
- Testing
- Non-Interventional
- Where
- 40 sites in United States
- Volunteers
- 1,574 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease (COPD, Arterial Hypertension
Intervention to Improve the Adherence in Community Pharmacies
The ANM is the first initiative that puts advanced pharmaceutical care into practice in Andalusia (Spain). The aim of this is study is to evaluate the effectiveness of the intervention Assistance to New Medicines (ANM) in the…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD, Arterial Hypertension, Diabetes Mellitus
- Trial name
- NCT04195191
- Testing
- ANM
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Andalusian School of Public Health
Chronic Respiratory Diseases
Intestinal Microbiota in COPD and Asthma
The composition of the intestinal microbiota, the level of lipopolysaccharides, TMAO in the blood, and other parameters of patients with COPD (n=50), asthma (n=50) and the control (n=40) will be assessed as factors associated…
- Trial name
- MicrObAs (NCT04802317)
- Testing
- Identification of the composition of the intestinal microbiota
- Where
- Russia
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine