Clinical trials: Chronic Pulmonary Obstruction
Chronic Obstructive Pulmonary Disease
A Phase II Study of CM326 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease
This study is a multi-center, randomized, double-blind, placebo-controlled Phase II clinical study to evaluate the efficacy, safety, PK characteristics, PD effects and immunogenicity of CM326 in subjects with moderate to Severe…
- Trial name
- NCT07418736
- Testing
- CM326 dose 1, CM326 dose 2
- Where
- China
- Volunteers
- 318 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Nasal Obstruction, Copd
Nasal Breathing and Physical Capacity
We know that there is a link between disorders in the upper and lower airways, both epidemiologically, patho-physiologically, and therapeutically.
- Trial name
- NCT04712799
- Testing
- Otrivin
- Where
- Norway
- Volunteers
- 67 people
- Sponsor
- Sorlandet Hospital HF
Patients With Chronic Rhinitis Who Failed Medical Treatment
A Randomized Study of Temperature-controlled and Bipolar Radiofrequency for Inferior Turbinate Reduction
Currently, there are several alternative treatments for patients with chronic rhinitis (CR) who failed medication. Although, most of the researches have been focusing on temperature-controlled RF (TCRF), the cost is a major…
- Trial name
- CompareRFIT (NCT01054521)
- Testing
- Temperature-controlled RF, Bipolar RF
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Mahidol University
COPD Exacerbation
Prevalence, Associated Factors Points and Implementation of Care Procedures of Chronic Obstructive Pulmonary Disease Exacerbation in Healthcare Institution
Chronic Obstructive Pulmonary Disease (COPD) is a public health problem responsible for high mortality rate and significant costs for society.
- Trial name
- OPEDEXA (NCT05682404)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Lung Diseases, Obstructive, Pulmonary Disease, Chronic Obstructive
Physical Activity Augmentation Using Pedometers During Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
Patients with chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), who perform regular physical activity, have improved health and wellbeing compared with those who do little exercise.
- Conditions
- Lung Diseases, Obstructive, Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic
- Trial name
- NCT01719822
- Testing
- Yamax Digi-Walker CW-700
- Where
- United Kingdom
- Volunteers
- 155 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Study on the Etiology, Risk Factors and Pathogenesis of COPD Based on Clinical Bioinformatics
The risk factors and causes of chronic obstructive pulmonary disease（COPD）are not clear, so the prevalence of COPD is high and the prevention effect is not good.
- Trial name
- NCT05069194
- Where
- China
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Chronic Obstructive Pulmonary Disease
Effect of CPAP on Respiratory Load in COPD
Both intrinsic positive end expiratory pressure (PEEPi) and dynamic hyperinflation are considered as inspiratory loads which increase work of breathing in patients with COPD.
- Trial name
- NCT06390631
- Testing
- Continuous Positive Airway Pressure
- Where
- China
- Volunteers
- 19 people
- Sponsor
- State Key Laboratory of Respiratory Disease
Chronic Obstructive Pulmonary Disease
Cardiovascular Effects of Pulmonary Rehabilitation in COPD
Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction, which is clinically manifested by dyspnea and leads the patient to a vicious cycle of sedentary lifestyle.
- Trial name
- NCT03943030
- Testing
- Pulmonary rehabilitation
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pulmonary Disease, Chronic Obstructive
Tiotropium in the Treatment of the Patients With Chronic Obstructive Pulmonary Disease
To collect post-marketing safety and effectiveness information on the use of Tiotropium Inhalation Capsules (18 μg) in patients with chronic obstructive pulmonary disease in daily clinical settings
- Trial name
- COPD (NCT02177318)
- Testing
- Spiriva (tiotropium bromide) inhalation capsules
- Where
- 418 sites in Japan
- Volunteers
- 3,588 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Aclidinium Bromide 400 µg Compared to Placebo and to Tiotropium Bromide in Patients With Stable Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The aim of the present study is to evaluate the 24h bronchodilatory efficacy of inhaled aclidinium bromide 400 µg administered twice a day versus placebo and tiotropium bromide, respectively, after 6 weeks of treatment.
- Trial name
- NCT01462929
- Testing
- Aclidinium bromide, Tiotropium
- Where
- 41 sites in Czechia, Germany and 2 more
- Volunteers
- 414 people
- Sponsor
- AstraZeneca
COPD
Causes of Appetite Loss in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The project looks at causes of appetite loss in patients with COPD. It is know that active systemic inflammation can lead to appetite loss and COPD is classified as a disease lead by inflammation.
- Trial name
- NCT04754256
- Testing
- Council of Nutrition Appetite Questionnaire - test for applicability in Danish COPD patients
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Jens Rikardt Andersen
Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Electrical Stimulation (NMES)
Effect of Neuromuscular Electrical Stimulation of Lower Limbs on Improving Exercise Self-Efficacy, Dyspnea During Activity and Fatigue in Patients With Chronic Obstructive Pulmonary Disease
Patients diagnosed with COPD who meet the inclusion and exclusion criteria, either inpatients or outpatients, will be informed about the study'sstudy's purpose and procedures by the principal investigator.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Electrical Stimulation (NMES), Exercise Self-Efficacy, Dyspnea During Activity
- Trial name
- NMES (NCT06851195)
- Testing
- lower limb neuromuscular electrical stimulation, pulmonary rehabilitation exercises
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Chronic Obstructive Pulmonary Disease
Study of Clinical and Patient-reported Outcomes in Adults With Moderate to Severe COPD Treated With Breztri/Trixeo
Chronic Obstructive Pulmonary Disease is a leading cause of global morbidity and mortality, especially in low- and middle-income countries. Exacerbations accelerate disease progression and increase the risk of death.
- Trial name
- iCHOROS (NCT07069829)
- Where
- 36 sites in Argentina, Colombia and 10 more
- Volunteers
- 1,400 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Effect of Oxygen-supply on 6-Minute-Walking-Distance of COPD III/IV-patients
The aim of this study is to investigate the six-minute-walking-distance of COPD-patients with breathing oxygen in comparison to breathing normal air.
- Trial name
- NCT00886639
- Testing
- 6MWT with oxygen, 6MWT with medical air
- Where
- Germany
- Volunteers
- 127 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Effects of L-arginine and Liposomial Vitamin C on Severe Copd Patients Undergoing Pulmonary Rehabilitation.
The hypothesis that is being tested is that the supplementation of L-arginine plus Vitamin C to multidisciplinary pulmonary rehabilitation (PR) in patients with a previous diagnosis of chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT06439875
- Testing
- effect of L-arginine and liposomial vitamin C on pulmonary rehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 101 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
COPD Exacerbation, PTE - Pulmonary Thromboembolism
The Appropriate Anticoagulation Duration for Chronic Obstructive Pulmonary Disease With Pulmonary Thromboembolism
Anticoagulation is the most important treatment for pulmonary thromboembolism (PTE). The thromboembolism risk is especially high in patients with chronic obstructive pulmonary disease (COPD) exacerbations.
- Trial name
- NCT03185845
- Testing
- Warfarin
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Chronic Airway Disease and Multimorbidity Cohort
Background: Chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis, are highly prevalent and cause serious disease burden.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Bronchiectasis
- Trial name
- CAM Cohort (NCT06798077)
- Where
- 9 sites in China
- Volunteers
- 2,000 people
- Sponsor
- China-Japan Friendship Hospital
Treatment of Chronic Obstructive Pulmonary Disease
De-implementing Inhaled Steroids to Improve Care and Safety in COPD
This Quality Enhancement Research Initiative (QuERI) project is designed to determine efficacy and acceptance of an intervention method to provide primary care providers with patient-tailored electronic consults and corresponding…
- Trial name
- DISCUSS COPD (NCT02896257)
- Testing
- Guideline treatment recommendations
- Where
- 2 sites in United States
- Volunteers
- 181 people
- Sponsor
- VA Office of Research and Development
COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbations
The REVIVE Pivotal Study
The goal of this study is to test whether a new treatment called the Ryme Medical Targeted Lung Denervation (TLD) Catheter is safe and effective for people with moderate to severe chronic obstructive pulmonary disease (COPD).
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbations, COPD Patients, COPD Acute Exacerbation
- Trial name
- REVIVE (NCT07361653)
- Testing
- Ryme TLD
- Volunteers
- 300 people
- Sponsor
- Ryme Medical, Inc.
Pulmonary Disease, Chronic Obstructive
Impact of Feedback on Physical Activity and Health-related Outcomes During Pulmonary Rehabilitation in COPD
The aim of this study is to investigate whether providing feedback on physical activity (PA) levels to patients with Chronic Obstructive Pulmonary Disease (COPD) is feasible and enhances daily PA and health-related outcomes…
- Trial name
- NCT02725931
- Testing
- Pulmonary rehabilitation (PR) plus PA-focused intervention
- Volunteers
- 20 people
- Sponsor
- Aveiro University
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