Clinical trials: Chronic Subdural Hematomas, open to volunteers
Subdural Hematoma
MMA Embolization With NeoCast for Subacute and Chronic Subdural Hematoma
The purpose of this study is to evaluate the safety and efficacy of embolization of the middle meningeal artery (MMA) using the NeoCast Embolic System for treatment of symptomatic subacute or chronic subdural hematoma (SDH)…
- Trial name
- RADIANT (NCT07541404)
- Testing
- NeoCast Embolic System, Onyx LES, an FDA-Approved Commercial Liquid Embolic
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Arsenal Medical, Inc.
Chronic Subdural Hematoma
Intra-Arterial Bevacizumab as an Adjunct to Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
This is a Phase 1, open-label, single-center, dose-escalation study evaluating the safety and tolerability of intra-arterial bevacizumab (IA-BEV) given as an adjunct to middle meningeal artery embolization (MMAE) in adults with…
- Trial name
- SAFER-MMAE (NCT07729098)
- Testing
- Bevacizumab (intra-arterial)
- Volunteers
- 18 people
- Sponsor
- Dheeraj Gandhi
Chronic Subdural Hematomas
Prospective MMA Embolization Registry
Chronic subdural hematoma (cSDH) is a common condition, particularly in older adults, that can substantially impair patients' quality of life, functional independence, and neurological well-being.
- Trial name
- PRO-EMMA (NCT07626671)
- Testing
- Middle Meningeal Artery Embolization
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Subdural Hematoma
Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study
The goal of this clinical trial is to test in moderately symptomatic chronic subdural hematoma (CSDH) patients if middle meningeal artery embolization (MMAE) can be used as an alternative to conventional open surgery.
- Trial name
- CHESS (NCT06347796)
- Testing
- Conventional Surgery, Middle Meningeal Artery Embolization (MMAE)
- Where
- 31 sites in United States
- Volunteers
- 520 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Chronic Subdural Hematoma
Spinal CSF Leaks in Chronic Subdural Hematoma
Background: Chronic subdural hematoma (cSDH) is a type of intracranial bleeding, predominantly affecting the elderly and males, with an estimated incidence of 8/100.000.
- Trial name
- SPICE (NCT06323434)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Freiburg
Chronic Subdural Hematoma
Frontal vs Parietal Eminence Drainage for Chronic Subdural Hematoma
This clinical trial aims to find out whether the puncture site used during minimally invasive surgery with twist-drill puncture and closed-system drainage affects the treatment of chronic subdural hematoma (cSDH).
- Trial name
- NCT07731620
- Testing
- Frontal-region puncture drainage, Parietal Eminence region puncture drainage
- Where
- 3 sites in China
- Volunteers
- 440 people
- Sponsor
- The Second Hospital of Anhui Medical University
Chronic Subdural Hematoma
Propofol Target-Controlled Infusion Versus Dexmedetomidine for Sedation During Chronic Subdural Hematoma Surgery Under Local Anesthesia
Chronic subdural hematoma is a collection of old blood on the surface of the brain that mainly affects older adults. It is often treated by draining the blood through a small hole in the skull (burr hole), under local anesthesia…
- Trial name
- NCT07912203
- Testing
- Dexmedetomidine, Propofol (Astra-Zeneca)
- Volunteers
- 60 people
- Sponsor
- National Institute of Neurology, Tunisia
Chronic Subdural Hematoma
Efficacy and Safety of Chinese Herbal HuoXue LiShui Formula for Chronic Subdural Hematoma
A prospective, randomised, double-blind, placebo-controlled, multicentre trial was designed to compare the the incidence of hematoma progression requiring operation or hematoma recurrence requiring re-operation and improves…
- Trial name
- CHARM (NCT06427980)
- Testing
- Chinese Herbal formula HuoXue LiShui
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Subdural Hematoma, Hemorrhage Brain
Microfabricated Microcatheter Advantages in Middle Meningeal Artery Embolization: an Early Experience at a Single Center
The purpose of this study is to evaluate the function of matched pair Aristotle 14 Guidewire and Plato Microcatheter in MMA embolization treatment for chronic subdural hematoma compared to surgeon's preference
- Trial name
- SCIENTIA (NCT07324551)
- Testing
- Matched pair Aristotle 14 guidewire and Plato 17 microcatheter, Surgeon combination preference
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Chronic Subdural Hematoma
Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH)
This study is an open label randomized controlled trial. Patients with a symptomatic Chronic Subdural Hematoma (CSDH) confirmed on radiological imaging, planned for surgery, age over 18, free from other intracranial pathologies…
- Trial name
- RATATA (NCT07245264)
- Testing
- Tranexamic Acid (Cyklokapron)
- Where
- India
- Volunteers
- 274 people
- Sponsor
- St. Olavs Hospital
Chronic Subdural Hematomas
Middle Meningeal Artery Coagulation During Burr-Hole Drainage for Chronic Subdural Haematoma (BURR-MMA)
Chronic subdural haematoma (cSDH) is a common condition in older adults, usually treated by burr-hole surgery to drain the collection.
- Trial name
- BURR-MMA (NCT07549893)
- Testing
- CT-Guided Intra-Operative Middle Meningeal Artery Interruption
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Chronic Subdural Hematoma, Chronic Subdural Hematomas
Implementation of an Enhanced Recovery Pathway for Burr-hole Drainage in Patients With a Chronic Subdural Hematoma
A chronic subdural hematoma (cSDH) is a type of intracranial hematoma that primarily affects older adults. The rising incidence of this condition, coupled with the high healthcare burden of this disease, calls for an update of…
- Trial name
- ERP-cSDH (NCT07421453)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
Hematoma, Subdural, Chronic
Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma
Rationale: Chronic subdural hematoma (cSDH) is a frequently occurring disease, occurring mainly in the elderly. Surgical evacuation is effective, but also associated with life-threatening risks.
- Trial name
- TORCH (NCT03582293)
- Testing
- Tranexamic Acid 500Mg Tablet
- Where
- Netherlands
- Volunteers
- 554 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Subdural Hematoma
Effect of Different Intravenous Fluids on Post-operative Chronic Subdural Hematoma Size and Recurrence
This study aims to reduce the recurrence rate of chronic subdural hematomas (CSDH) by manipulating the post-operative intravenous fluid use.
- Trial name
- NCT03831997
- Testing
- Dextrose 5% W/ Sodium Chloride 0.225%
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Carilion Clinic
Chronic Subdural Hematomas
Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.
Chronic subdural hematoma (cSDH) is a very common disease, primarily affecting older people, and is associated with significant morbidity and mortality.
- Trial name
- iSDH (NCT07556991)
- Testing
- Amoxicillin + clavulanic acid
- Where
- Germany
- Volunteers
- 164 people
- Sponsor
- University of Rostock
Middle Meningeal Artery Embolization, Chronic Subdural Hematomas
Middle Meningeal Artery Embolization in Patients With Chronic Subdural Hematoma
Primary : to evaluate the efficacy of MMAE on resolution and recurrence of hematoma in patients with CSDH. Secondary : evaluate the effect of MMAE on functional outcome, radiological changes, the need to repeat surgery, duration…
- Trial name
- NCT07806552
- Testing
- middle meningeal artery embolization
- Volunteers
- 35 people
- Sponsor
- Assiut University
Chronic Subdural Hematoma
Assessing Outcomes of Coil Embolization for Unilateral vs Bilateral Chronic Subdural Hematomas
This is a pragmatic, prospective, multicenter, randomized controlled trial with intention to treat analysis. In which subjects will receive either unilateral or bilateral middle meningeal artery (MMA) embolization using coils for…
- Trial name
- (COAST) (NCT07715656)
- Testing
- embolization therapy Bilateral, embolization therapy Unilateral
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Lahey Clinic
Chronic Subdural Hematoma, Recurrence
The Effectiveness and Safety of Body Posture in Preventing Postoperative Recurrence for Chronic Subdural Hematoma
This study aims to investigate the effectiveness and safety of body posture to improve intracranial pressure in preventing postoperative recurrence for chronic subdural hematoma
- Trial name
- NCT06401772
- Testing
- Intracranial Hypotension Targeted(IHT) Body Posture
- Where
- China
- Volunteers
- 830 people
- Sponsor
- Huashan Hospital
Chronic Subdural Hematomas
PHIL™ Middle Meningeal Artery Embolization for First-Line Treatment of Chronic Subdural Hematoma IDE Trial
This is a prospective, randomized, controlled, open-label, blinded endpoint (PROBE) clinical investigation in which patients with non-emergent chronic subdural hematoma (cSDH) requiring treatment will be randomized (1:1) to…
- Trial name
- PHILFIRST (NCT07576998)
- Testing
- PHIL™ (Precipitating Hydrophobic Injectable Liquid), Surgical evacuation
- Volunteers
- 475 people
- Sponsor
- Microvention-Terumo, Inc.