Clinical trials: Clinical High-risk
Atrial Fibrillation (AF)
Energy Dose and Cardioversion Outcomes in AF
This multicenter, randomized study will compare two electrical cardioversion energy strategies in adults with atrial fibrillation who are scheduled to undergo cardioversion during atrial fibrillation ablation or within 3 months…
- Trial name
- LE-HI-CV (NCT07884253)
- Testing
- Synchronized Electrical Cardioversion With Different Energy Strategies, Conventional Step-Up Energy Cardioversion
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Prostate Cancer Screening
Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.
The purpose of this study is to compare whether the FDA and Health Canada approved microUS is as effective as the currently used option (MRI) for imaging the prostate gland.
- Trial name
- MUSIC-Screen (NCT06626022)
- Testing
- MRI, ExactVu
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 1,284 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Myopia, High Myopia
Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia
Small Incision Lenticule Extraction (SMILE) was introduced in 2011 using the VISUMAX femtosecond laser (Carl Zeiss Meditec, Jena, Germany). It is designed for correction of myopia and myopic astigmatism.
- Trial name
- NCT04110067
- Testing
- Small Incision Lenticule Extraction (SMILE) with Visumax (Carl Zeiss Meditec, Jena)
- Where
- Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Suphi Taneri
Follicular Lymphoma
A Multi-center Clinical Study of Zanubrutinib in Combination With First-line Chemoimmunotherapy in Patients With Grade 3A High-risk Follicular Lymphoma
Background： At present, there is controversy about whether FL3a is treated as FL or DLBCL. Relevant studies have shown that compared with patients with FL3a grade 1~2, they have unique immunohistochemical characteristics, and…
- Trial name
- ZCM3AHRFL (NCT06742879)
- Where
- China
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Zhengzhou University
Healthy People
HIIH Versus HMC: Randomized Clinical Trial
Introduction: water aerobics involves the practice of specific aquatic exercises that are based on the use of water resistance as a load and on thrust as an impact reducer, making it possible to perform physical exercise with a…
- Trial name
- HIITxHMC (NCT03293056)
- Testing
- High-intensity interval Hydrogynmastics, Hydrogynmastics Continuous Moderate
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do vale do São Francisco
Myopia, Moderate
To Compare the Clinical Outcomes of FemtoLASIK and ICL Implantation in Treating Moderate Myopia Focusing on Refractive Stability, Contrast Sensitivity and High Order Aberrations.
Compare the clinical outcomes of FemtoLASIK and ICL implantation in treating moderate myopia.
- Trial name
- NCT07291986
- Testing
- FemtoLASIK, ICL implantation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Walid Osama Abdel Rahman Nour El Din
Obesity, Overweight
Microvascular and Metabolic Effects of High-intensity Interval Exercise Training
The study investigates the effects of high intensity interval training (HIIT) versus continuous training (CT), combined or not with fasting, on capillary density, microvascular function, cardiometabolic risk markers, functional…
- Conditions
- Obesity, Overweight, Physical Activity
- Trial name
- HIIT-FAST (NCT03236285)
- Testing
- High-intensity interval exercise training in the fed state, Continous exercise training in the fed state, High-intensity interval exercise training in the fasting state
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Anesthesia, Intraocular Pressure
Intraocular Pressure, Optic Nerve Sheath Diameter and Optic Perfusion Pressure of Minimal Low and High-Flow Anesthesia
The aim of this clinical trial is to determine the effect of minimal low-flow versus high-flow anesthesia on intraocular pressure (IOP) by non-contact tonometry, optic nerve sheath diameter (ONSD) by USG and optic perfusion…
- Conditions
- Anesthesia, Intraocular Pressure, Nephrolithiasis
- Trial name
- NCT06684704
- Testing
- minimal and high flow anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Depressive Symptoms, Hypomania Nos Single Episode or Unspecified
A Study of Aerobic Exercise for Adolescents With Subthreshold Mood Syndromes
This study will investigate the effects of aerobic exercise on mental states, cognition, and long-term outcomes in adolescents with subthreshold depressive and/or hypomanic syndromes and in non-clinical school children
- Trial name
- NCT03300778
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Underage Drinking, Drinking, Teen
Examining an Intervention to Reduce High School Drinking
Underage drinking is a significant problem in the United States. While past research supports the efficacy of interventions in delaying the initiation of alcohol use implemented in middle school and early high school, research…
- Conditions
- Underage Drinking, Drinking, Teen, Adolescent Alcohol Use
- Trial name
- NCT07086508
- Testing
- e-CHECKUP TO GO (eCTG), e-Parent Intervention
- Where
- United States
- Volunteers
- 2,532 people, healthy volunteers welcome
- Sponsor
- Binghamton University
Educational Problems, Anatomical Pathological Condition
3D Resin Printed Fracture Models for Anatomy Education
Resin printing is an emerging technology with a wide array of applications. This research seeks to assess the practicality of incorporating 3D resin printed models into anatomy education while investigating how fractured models…
- Trial name
- NCT06061003
- Testing
- Clinical Anatomical Education with Fractured Bone Models, Clinical Anatomical Education with Standard Bone Models
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Pulmonary Arterial Hypertension
A Study to Learn About the Study Medicine Called PF-07868489 in Healthy Adult People and in People With Pulmonary Arterial Hypertension
The purpose of the study is to learn how the study medicine called PF-07868489 is tolerated and acts in healthy adult people and people with pulmonary arterial hypertension (PAH).
- Trial name
- NCT06137742
- Testing
- PF-07868489
- Where
- 46 sites in United States, Australia and 10 more
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Subjects
A Clinical Trial to Evaluate a High-Fat Meal and Omeprazole Enteric-coated Tablets on ASBK021
Part A: a single-center, randomized, open-label, three-cycle study to evaluate the pharmacokinetic (PK) profile of different doses of ABSK021 Capsules and the effect of a high-fat meal on the pharmacokinetic profile of ABSK021…
- Trial name
- NCT06322706
- Testing
- ABSK021, Omeprazole
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Abbisko Therapeutics Co, Ltd
Older Adults at High Risk for MCI, Older Adults With Mild to Moderate Level of Dementia
STRONGER 60+: Assessing the Clinical Effectiveness and Delivery of an Adapted FINGER Model for Brain Health in Primary Care
Background: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was the first to show that multidomain lifestyle interventions can enhance brain health and reduce cognitive decline.
- Trial name
- STRONGER (NCT07117916)
- Testing
- Supervised nutritional guidance, physical exercise, cognitive training, social engagement, and management of vascular and metabolic risk factors., Self-Guided
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cholelithiasis, Gall Bladder Disease
3D HD Versus 2D HD in Cholecystectomy
The aim of this study is to compare 3D-laparoscopy versus 2D-laparoscopy with the use of HD resolution in cholecystectomy in terms of error rating, performance time and subjective assessment.
- Trial name
- NCT02396927
- Testing
- 3D HD laparoscopy, 2D HD laparoscopy
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Dental Restoration Failure
Clinical Performance of Bioactive Restorative Material Versus Glass Hybrid Restorative in Posterior Restorations
Clinical performance of bioactive restorative material versus glass hybrid restorative in posterior restorations of high caries risk patients will be evaluated over 12 months using Fédération Dentaire Internationale' (FDI)…
- Trial name
- NCT03608306
- Testing
- Resin-modified glass ionomer, Bulk-fill glass hybrid restorative
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Learning Process in Nursing Graduation, Compliant Behavior
Effectiveness of High Fidelity Simulation for Safety in the Medication Process in Intensive Care
Nursing plays an important role in the medication process in intensive care units. The application of active methodologies guided by the simulation strategy can help in the formation of qualified professionals and in the safer…
- Trial name
- NCT03828526
- Testing
- High Fidelity Simulation, Traditional teaching strategy
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
High Caries Risk Patients, Antimicrobial Effect
Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients
This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients. Also salivary pH and patient satisfaction to taste will also be tested.
- Conditions
- High Caries Risk Patients, Antimicrobial Effect, Salivary pH, Patient Satisfaction to Taste
- Trial name
- NCT03773094
- Testing
- Guava leaves extract, Chlorhexidine
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cairo University
Secondary Dental Caries
Assessment of Bioactive Bulk Fill Composite Versus High Viscosity Glass Ionomer Restorations for Carious Lesions
This trial will be conducted to compare the clinical performance between a new bioactive resin composite material and high viscosity glass ionomer for restoring occlusal carious lesions of posterior teeth in patients scheduled…
- Trial name
- NCT05332041
- Testing
- Predicta Bioactive bulk fil composite restoration
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer
Internal Mammary Lymph Nodes Irradiation in High-risk Breast Cancer After Neoadjuvant Chemotherapy
The aim of this study is to explore the impact of internal mammary nodal irradiation on disease-free survival in high-risk breast cancer patients (ypN+or supra/subclavicular lymph node positive) after neoadjuvant chemotherapy.
- Trial name
- NCT06559696
- Testing
- internal mammary nodal irradiation, No internal mammary node irradiation
- Where
- China
- Volunteers
- 722 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital