Clinical trials: Closed-loop Brain Stimulation
Essential Tremor
Wearable Sensor for Responsive DBS for ET
The purpose of this study is evaluate the effectiveness and safety of a possible new treatment for Essential Tremor (ET) using external wearable sensors, which have the capability of recording acceleration and Electromyography…
- Trial name
- NCT03051178
- Testing
- Responsive deep brain stimulation
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Florida
Parkinson's Disease
Concurrent DBS Local Field Potential Analysis and Stimulation in a Closed-Loop Neuromodulation Device
The purpose of this clinical study is to allow the investigation of local field potential (LFP) signals in patients treated with DBS of the STN.
- Trial name
- NCT02731365
- Testing
- Activa PC+S
- Where
- United States
- Sponsor
- Vibhor Krishna
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder
The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD).
- Trial name
- NCT06660225
- Testing
- Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nader Pouratian
Parkinsons Disease
A Responsive Closed-Loop Approach to Treat Freezing of Gait in Parkinson's Disease
The study objective is to explore Deep Brain Stimulation (DBS) in two specific brain regions (Globus Pallidum, or GPI, plus the pedunculopontine nucleus, or PPN) for on medication freezing of gait (FoG) in Parkinsons Disease…
- Trial name
- NCT02318927
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Closed-loop Brain Stimulation
Closed-loop tES-non-invasive Stimulation
The goal of this study is to establish if non-invasive closed-loop neuromodulation is an effective approach to enhance cognitive function in healthy 18-40 years old volunteers.
- Trial name
- CLIBM (NCT07671079)
- Testing
- Transcranial low intensity focused ultrasound (FUS), transcranial electrical stimulation, Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parkinson Disease
Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait Using Neural and Kinematic Feedback
Deep Brain Stimulation of the subthalamic nucleus (STN) has become a standard of care, FDA-approved treatment for Parkinson's disease, with stimulation delivered at a constant amplitude and voltage, operating in an open-loop…
- Trial name
- NCT04043403
- Testing
- Open Loop DBS, Adaptive (Closed Loop) DBS, Intermittent Open Loop DBS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Parkinson Disease
Trial of Adaptive Deep Brain Stimulation
Currently, treatment of Parkinson's Disease with deep brain stimulation (DBS) uses continuous high frequency stimulation. The investigators have previously shown that by controlling the stimulation using feedback from the brain…
- Trial name
- NCT03724734
- Testing
- Adaptive DBS, Conventional DBS
- Volunteers
- 15 people
- Sponsor
- St. George's Hospital, London
MCI
Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment
This research study investigates the feasibility and efficacy of a personalized, closed-loop electroencephalogram-transcranial electrical stimulation (EEG-tES) intervention for individuals with mild cognitive impairment (MCI)…
- Trial name
- NCT07512193
- Testing
- Active tES, Cognitive Interventions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Prehypertension, Blood Pressure
HIRREM for Pre-Hypertension
This randomized, controlled clinical pilot trial will evaluate the effects associated with in-office use of closed-loop, acoustic stimulation neurotechnology (High-resolution, relational, resonance-based, electroencephalic…
- Conditions
- Prehypertension, Blood Pressure, Autonomic Nervous System Imbalance, Cardiovascular Risk Factor
- Trial name
- NCT03332043
- Testing
- HIRREM, Ambient Nature Sounds
- Sponsor
- Wake Forest University Health Sciences
Stroke
A Closed-loop Brain-computer Interface for Stroke
It may be hard to acquire stable sensorimotor rhythm from the affected motor cortex for patient without a response of paretic hand.
- Trial name
- NCT04465786
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Fear, PTSD
Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation
This study aims to specifically examine the in vivo electrophysiology and effects of direct stimulation of the human amygdala during conditioned and evoked fear.
- Conditions
- Fear, PTSD, Panic Disorder
- Trial name
- NCT03958903
- Testing
- Amygdala recording and stimulation using Neuropace RNS, Behavioral tasks
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Spinal Cord Injuries, Nerve Injury
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional…
- Conditions
- Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia
- Trial name
- NCT04144972
- Testing
- Medtronic Summit RC+S or Percept RC
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Epileptic Seizure, Epilepsy Intractable
REC2Stim as a Treatment for Refractory Epilepsy in the Primary Sensorimotor Cortex.
People with central lobe epilepsy (CLE), with seizures arising from the primary sensorimotor cortex, typically show a high rate of convulsive seizures that do not respond to anti-epileptic drugs, but have a large impact on…
- Conditions
- Epileptic Seizure, Epilepsy Intractable, Motor Seizure
- Trial name
- REC2Stim (NCT04158531)
- Testing
- ECoG sensing and stimulation
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Sleep, Insomnia
Modulation of Sleep Perception Through Auditory Closed-loop Stimulation of Brain Oscillatory Activity
Sleep is ubiquitous in animals and humans, and disruptions are of high clinical importance. Still, the neural basis of sleep perception is insufficiently understood, which limits the development of new treatments.
- Trial name
- NCT04276064
- Testing
- Auditory closed-loop stimulation: slow oscillation boosting, Auditory closed-loop stimulation: slow oscillation disruption
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Christoph Nissen
Sleep Disturbance, Stress, Psychological
Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement
This study evaluates a wearable system (NEUSleeP) that combines overnight EEG recording with transcranial focused ultrasound (tFUS) targeted to deep brain structures involved in REM sleep regulation (e.g., subthalamic nucleus).
- Conditions
- Sleep Disturbance, Stress, Psychological, REM Sleep Measurement
- Trial name
- NEUSleeP (NCT07190287)
- Testing
- NEUSleeP system (FUS-EEG wearable device), BrainSonix Pulsar 1002
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Parkinson Disease
Adaptive Deep Brain Stimulation to Improve Motor and Gait Functions in Parkinson's Disease
This is a single-center phase I clinical study aiming to improve gait functions in patients with Parkinson's disease (PD) by using adaptive neurostimulation to the pallidum.
- Trial name
- NCT04675398
- Testing
- Summit RC+S
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Doris Wang, MD, PhD
Chronic Pain, Post Stroke Pain
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief.
- Conditions
- Chronic Pain, Post Stroke Pain, Phantom Limb Pain, Spinal Cord Injuries
- Trial name
- NCT03029884
- Testing
- Open-Loop DBS, Closed-Loop DBS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Prasad Shirvalkar, MD, PhD
Stroke, Motor Dysfunction
Closed-Loop SCS-BCI for Post-Stroke Hemiplegia
This study evaluates a new closed-loop rehabilitation system for stroke survivors with arm weakness. The system combines a brain-computer interface (BCI, a special cap that reads brain signals), spinal cord stimulation (a…
- Conditions
- Stroke, Motor Dysfunction, Brain-computer Interface, Spinal Cord Stimulation (SCS)
- Trial name
- CL-SCS-BCI (NCT07903116)
- Testing
- Spinal Cord Stimulation, Non-invasive Brain-Computer Interface, Hand Exoskeleton
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson Disease
CANadian Adaptive DBS TriAl
Parkinsonian symptoms, such as freezing of gait (FOG) or hypophonia, play a significant role in reducing quality of life for Parkinson disease (PD) patients, and are poorly responsive or can worsen with deep brain stimulation…
- Trial name
- CANADA (NCT05402163)
- Testing
- Adaptive DBS, Continuous DBS
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Toronto
Migraine Disorders
Closed-loop RTMS for Short-term Migraine Prevention
Migraine is a prevalent and debilitating primary headache disorder, where patients suffer from disabling symptoms that usually consist of a moderate to severe headache lasting 4 to 72 hours, nausea and/or vomiting, phonophobia…
- Trial name
- NCT06735768
- Testing
- rTMS treatment, Determination of motor hotspot and motor treshold
- Where
- Austria
- Volunteers
- 88 people
- Sponsor
- Brightmind.AI