Clinical trials: Cocaine-Related Disorders
Cocaine Dependence
Gender Differences in Response to Cues in Cocaine Dependence
The purpose of this study is to evaluate whether men and women respond differently to seeing items related to cocaine use or to remembering stressful events.
- Trial name
- NCT00969943
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Use Disorder, Alcohol Use Disorder
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results.
- Trial name
- NCT06552741
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Human Behavioral Pharmacology Laboratory Study of Varenicline's Impact on Cocaine Reinforcement
Cocaine use, abuse and dependence is a public health problem that is directly responsible for hundreds of billions of dollars in health care expenditures per year.
- Trial name
- NCT01143857
- Testing
- Varenicline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jennifer Plebani
Cocaine Dependence, Impulsivity
Impulsivity and Stimulant Administration
Examine the interaction between stimulants, such as cocaine and methylphenidate, and impulsivity.
- Trial name
- NCT01978431
- Testing
- cocaine hydrochloride, methylphenidate
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Use, Cocaine Dependence
Effect of rTMS on Neurotrophines Levels in CUD
Brief Summary: Background: Cocaine use disorders (CUD) is a multifactoral disease, involving several brain areas. One of the most investigated is the Dorsolateral Prefrontal Cortex (DLPFC) involved in impulsiveness control.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Abuse, Neurotropism
- Trial name
- BDNFcoca (NCT05824221)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Cocaine Dependence
Cocaine Use Disorder and Cortical Dopamine
The goal of this study is to use [C-11]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls
- Trial name
- NCT03349606
- Testing
- d-amphetamine, [C-11]FLB 457
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cocaine-Related Disorders, Opioid-Related Disorders
Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3
The purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in concurrent cocaine and opiate dependent patients.
- Trial name
- NCT00000306
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Impulsivity, Neural Deficits and Cocaine Addiction
The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of…
- Trial name
- NCT00744601
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Substance Abuse Problem, Pregnancy
Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology
The purpose of this research is to study the effects of nasal oxytocin administration on maternal behaviors that may be influenced by cocaine use during pregnancy.
- Trial name
- NOX (NCT02872467)
- Testing
- Syntocinon treatment
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cocaine Use Disorder, Substance Use Disorders
Multiple Ascending Dose Study of TMP-301 in Healthy Subjects
A PHASE 1, RANDOMIZED, PLACEBO CONTROLLED, MULTIPLE ASCENDING DOSE (MAD) STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF TMP-301 IN HEALTHY SUBJECTS.
- Conditions
- Cocaine Use Disorder, Substance Use Disorders, Healthy Volunteers
- Trial name
- NCT06025396
- Testing
- Cohort 1 - TMP-301, Cohort 2 - TMP-301, Cohort 3 - TMP-301
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tempero Bio, Inc.
Cocaine Dependence, in Remission
AAV8-hCocH for Cocaine Use Disorder
The purpose of this study is to test the safety of a novel gene viral vector treatment for adults with cocaine use disorder-sustained remission.
- Trial name
- NCT04884594
- Testing
- AAV8-hCocH
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- W. Michael Hooten
Cocaine Dependence
Effects of Vigabatrin on Cocaine Self-Administration
The objective of this study is to determine if vigabatrin will decrease cocaine self-administration, cardiovascular effects, subjective effects and craving compared to placebo.
- Trial name
- NCT00373581
- Testing
- Vigabatrin, Cocaine
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Ovarian Hormones and Stress Induced Drug Craving
The study is investigating the impact of progesterone and estrogen on brain areas that are involved with stress response and drug craving.
- Trial name
- NCT02098434
- Testing
- Montreal Imaging Stress Task
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
First in Humans Study of JDTic
This is the first study to be conducted in humans for JDTic, a new chemical entity, with evaluations focusing on the safety, tolerability, and pharmacokinetics (PK) of JDTic following administration of single oral doses.
- Trial name
- NCT01431586
- Testing
- JDtic
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- RTI International
Cocaine Dependence
5HT2CR Balance in Brain Connectivity in Cocaine Dependence
This project will evaluate the role of the 5-HT2CR:5-HT2AR balance in impulsive action and cue reactivity in cocaine-dependent subjects as compared to non-drug using controls.
- Trial name
- NCT03921151
- Testing
- Mirtazapine 15 MG Oral Tablet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Behavior Therapy, Cocaine
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained.
- Conditions
- Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence
- Trial name
- NCT00158288
- Testing
- LAAM
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts.
- Trial name
- NCT03471182
- Testing
- Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Dependence
Therapeutic Cocaine Vaccine: Human Laboratory Study
Clinical data demonstrate that a cocaine vaccine (TA-CD: Celtic Pharmaceutical) produces selective anti-cocaine antibodies, yet the impact of these antibodies on cocaine's direct effects is unknown.
- Trial name
- NCT00965263
- Testing
- Cocaine vaccine (TA-CD)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Cocaine Abuse
Computer-Based Training in Cognitive Behavior Therapy
The computer-based training program (CBT for CBT) focuses on teaching basic coping skills, presenting examples of effective use of coping skills in a number of realistic situations in video form, and providing opportunities for…
- Trial name
- CBT4CBT (NCT00350610)
- Testing
- Treatment as usual (TAU), CBT for CBT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University