Clinical trials: Cognitive/Functional Effects
Aging Well
Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
This study will analyze the influence of acute bout exercise intensities (continuous moderate and HIIT) on middle cerebral artery velocity (MCAv) to identify which intensity elicits the greatest increase in CBF in older adults…
- Trial name
- NCT05131217
- Testing
- Acute bout of Continuous Moderate Intensity Exercise, Acute bout of High Intensity Interval Training, Control
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cognitive Function and Memory
Cognitive Effects of a Dietary Supplement With PQQ, GABA, Caffeine, and B-Vitamins in Healthy Postmenopausal Women: A Randomized Controlled Trial
Various food supplements have been shown to improve cognitive function. However, there is limited data on the impact of these supplements on postmenopausal women.
- Trial name
- NCT06748989
- Testing
- Cortexium food supplement
- Where
- Hungary
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- FEMPHARMA Kft.
Human Volunteers
The Effects of a Novel NMDA NR2B-Subtype Selective Antagonist, EVT 101, on Brain Function
The purpose of this study is to investigate the neurophysiological changes following single doses of EVT 101 using fMRI during rest and during cognitive tasks in young healthy male subjects.
- Trial name
- NCT00526968
- Testing
- EVT 101
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Evotec Neurosciences GmbH
Cognitive Decline
Effects of Multidomain Intervention on Cognitive Function in Community-dwelling Elderly
The aging population has contributed to an increase in cognitive decline. To mitigate the rise in the dementia population, it is crucial to prevent cognitive decline in older adults with normal functioning, subjective cognitive…
- Trial name
- NCT06180161
- Testing
- multidomain intervention
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cognitive Ability, General
Effect of Sage Extract Supplementation on Cognitive Function in Middle-Aged Men and Women
Sage (Salvia officinalis) has been reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Several studies indicate that sage supplementation can improve cognitive function.
- Trial name
- NCT07757529
- Testing
- SageXtra
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Sub-optimal Cognitive Function, Sub-optimal Immune Function
Evaluating Whole Foods Supplementation on Cognition
A six-month study which investigated the effect of Ginkgo Synergy® and Choline or OPC Synergy® and Catalyn® on cognitive and immune function markers and quality of life among healthy older adults with no history of significant…
- Trial name
- NCT01672359
- Testing
- Ginkgo Synergy® and Choline, OPC Synergy® and Catalyn
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Miami
Vitamin D Deficiency, Metabolic Syndrome
Vitamin D Supplementation and Metabolism in Vitamin D Deficient Elderly
The purpose of this study is to examine the effects of Vitamin D supplementation on the reasons (mechanisms) underlying the development of type 2 diabetes, metabolic syndrome (high blood pressure, cholesterol, diabetes, body…
- Trial name
- VitD (NCT01145703)
- Testing
- RDA Vitamin D3 only, Vitamin D2/3 Repletion only, Vitamin D2/3 Repletion + AEX
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Executive Function (Cognition), Soccer Training
Cognitive-Integrated Soccer Training and Performance
This study will examine whether an 8-week soccer-specific cognitive-motor training program can improve executive functions, decision-making, and soccer skill performance in youth soccer players.
- Conditions
- Executive Function (Cognition), Soccer Training, Performance, Motor Development
- Trial name
- NCT07284940
- Testing
- Cognitively Engaging Soccer Practice, Conventional Soccer Practice
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Fan Mao
Subjective Cognitive Impairment, Mild Cognitive Impairment
Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease
The purpose of this study is to investigate the beneficial effects of regular exercise and the impact of food supplement carnosine on cognitive, motoric and metabolic functions as well as on specific biologically active…
- Conditions
- Subjective Cognitive Impairment, Mild Cognitive Impairment, Parkinson Disease, Healthy Volunteers
- Trial name
- NCT03330470
- Testing
- exercise, carnosine supplementation, stretching
- Where
- 3 sites in Slovakia, Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Cerebral Glucose Metabolism
Development of a Non-invasive Method for Quantifying Cerebral Glucose Metabolism for Studying the Effect of Glucagon in Humans
The aim of the study is to develop a non-invasive method for quantifying cerebral glucose metabolism by PET scans in humans. This method will be used in subsequent studies, where the effect of the pancreatic hormone glucagon on…
- Trial name
- NCT06647368
- Testing
- PET with 18-FDG
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Nicolai Jacob Wewer Albrechtsen
Older People
Explore the Effects of Virtual Reality Natural Environment of Older People
The objective of this study is to evaluate the effectiveness of virtual natural environment interventions on attention and mood among community-dwelling older adults in Taiwan.
- Trial name
- NCT05803460
- Testing
- Experimental group: Actual nature group, Experimental group: Virtual nature group, Control group: Actual urban group
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Subjective Cognitive Decline
Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance of individuals with subjective cognitive decline.
- Trial name
- preSmartAge (NCT02755246)
- Testing
- Polyamine supplementation
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Schizophrenia
The Effects of Nicotine on Cognition in Schizophrenia
Patients with schizophrenia have a variety cognitive deficits and nicotine has been shown to normalize some of these deficits. The purpose of this study is to investigate the effects of nicotine on cognition in schizophrenia.We…
- Trial name
- NCT00383747
- Testing
- transdermal nicotine patch
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Infant Nutrition
Effect of Feeding Mode on Infant Growth and Cognitive Function
This study is intended to compare growth, nutritional status, and brain development in children fed an Investigational cow's milk based formula containing a nutrient-rich whey protein, a standard cow's milk based formula, or fed…
- Trial name
- NCT02626143
- Testing
- Investigational nutrient-rich whey protein formula, Cow's milk based formula
- Where
- Chile
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Healthy Volunteers
Evaluation of the Effects of Etifoxine 100 mg and Lorazepam 2 mg on Vigilance and Cognitive Functions in the Elderly
The purpose of this study is to evaluate the effects of etifoxine (an anxiolytic) compared to lorazepam (a benzodiazepine anxiolytic) on vigilance and cognitive functions in the elderly.
- Trial name
- NCT02147548
- Testing
- etifoxine, lorazepam
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Biocodex
Nitrous Oxide Poisoning
Effects of Low Concentrations of Nitrous Oxide
The aim of the study is to test the effects of low concentrations of nitrous oxide on cognitive functions and reaction time in human.
- Trial name
- NCT04050267
- Testing
- Nitrous Oxide
- Where
- Czechia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Brain Function
Effects of a Breakfast and Snack on Cognitive Function in Preadolescents
This study is designed to test how breakfast affects brain function, memory and learning in healthy children. Hypotheses: Based on the results of our initial study and the relevant literature, it is hypothesized that arousal…
- Trial name
- NCT01592487
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arkansas
Cognitive Function
Effect of Sprint Interval Training and Intermittent Fasting on Cognitive Function
Several lifestyle modifications, such as manipulating diet and exercise, have been shown to enhance cognitive function. This study aims to determine if a combination of Sprint Interval Training (SIT) and Time Restricted Eating…
- Trial name
- NCT05152719
- Testing
- Cognitive Performance
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Aging
Effects of Dance on Reaction Time in Experienced Older Adults
Aim of this study was to investigate the effects of 6-month ballroom dance (3 times/wk) on physical fitness and reaction time in twenty- four experienced older adults.
- Trial name
- NCT04680364
- Testing
- partnered dance
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia