Clinical trials: Cognitive Aging
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Older Adults, Aging Brain
Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease
The primary objective of this study is to evaluate the effects of the experimental treatment (cognitive training) further outlined in this protocol on the cognitive abilities (e.g., processing speed, attention, working memory…
- Trial name
- PACR-AD (NCT02331784)
- Testing
- Computerized Plasticity-based Software, Commercially available Video Game
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Expectation Effects on Emotional Processing in Late Life
Expectation Effects on Emotional Processing in Late Life
Understanding the mechanisms of expectation effects in the affective system is vital, given high placebo rates in antidepressants. Evidence has consistently confirmed that expectations can influence our emotional experience.
- Trial name
- NCT06251284
- Testing
- Saline nasal spray
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Conditions or Focus of Study: Cognitive Function Loneliness Aging Physical Activity
Wearable-Assisted Walking for Cognitive Function and Loneliness in Older Adults
Participants in the wearable-assisted walking group were asked to walk five days per week for approximately 30 minutes per session at moderate intensity.
- Trial name
- WAW-CogLon (NCT07650292)
- Testing
- Wearable-Assisted Walking Program
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan College of Performing Arts
Aging, Visual Perception
RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging
The RePer-AGE study investigates how central and peripheral vision contribute to visual recognition and how these mechanisms change with normal aging.
- Conditions
- Aging, Visual Perception, Cognition
- Trial name
- RePer-AGE (NCT07727369)
- Testing
- Psychophysical visual recognition tasks, Ophthalmological assessment, Functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Mental Processes
The Effects of Flavonoid Supplementation on Cognition and Neural Mechanisms in Healthy Older Adults
A double-blind, randomised, controlled, parallel arm chronic intervention trial with healthy older adults will be conducted to determine the effect of a flavonoid-rich supplement on cognitive function, peripheral arterial health…
- Trial name
- CoCo_Chronic (NCT03030053)
- Testing
- Cocoa-Flavanol Supplements, Control Supplements
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cognition, Neurovascular Coupling Mechanism and Cognitive Function
The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults
The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular…
- Conditions
- Cognition, Neurovascular Coupling Mechanism and Cognitive Function, Neurovascular Control, Brain Aging
- Trial name
- NCT07209683
- Testing
- transcranial photobiomodulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Mild Cognitive Impairment, Alzheimer Disease (AD)
Microbiome in Aging of Gut and Brain
The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease (AD), Dementia
- Trial name
- MiaGB (NCT07799402)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Time Restricted Eating
Cerebromicrovascular Effects of Time-Restricted Eating in Older Adults
The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through…
- Trial name
- NCT05488652
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Executive Functions, Memory Functions
Multi-domain Versus Uni-Domain Training on Executive Control and Memory Functions of Older Adults
Age-related cognitive decline affects negatively daily living and quality of life of older adults. Previous research has shown a moderate impact of cognitive and physical training on the cognitive functioning of elders.
- Trial name
- VIBAL (NCT03823183)
- Testing
- Cognitive training, Physical training, Cognitive control
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Educación a Distancia
Mild Cognitive Impairment, MCI
Neuromodulation of Memory in Aging
The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states.
- Trial name
- TMS-AD (NCT05460468)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hearing Impaired
Brain and Cognitive Changes After Reasoning or Physical Training in Cognitively Normal Seniors
Seniors 65 years of age and older represent one of the fastest growing segments of society with the population doubling within the next 25 years with dramatic rates of mental decline, costing society billions of dollars each…
- Trial name
- NCT00977418
- Testing
- SMART- Strategic Memory and Reasoning Training, Physical Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Ageing, Mitochondrial Function
The Effect of Fish Oils With Dairy or Plant Based Lipids on Mitochondrial and Physical, and Cognitive Function, in Elderly Humans
The aim of this study is to determine whether dairy or plant based fats combined with fish oils can alter skeletal muscle mitochondrial, physical, and cognitive function.
- Conditions
- Ageing, Mitochondrial Function, Physical Function, Cognitive Function
- Trial name
- NCT04194983
- Testing
- Fish oils and dairy fat, Fish oils and plant fat
- Where
- 2 sites in Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Noise Correlations, Learning Quality
Investigating The Role of Noise Correlations in Learning
A fundamental problem in neuroscience is how the brain computes with noisy neurons. An advantage of population codes is that downstream neurons can pool across multiple neurons to reduce the impact of noise.
- Trial name
- NCT06673303
- Testing
- Dynamic perceptual discrimination task, fMRI
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Brown University
Cognitive Impairment, Dementia
COcoa Supplement and Multivitamin Outcomes Study for the Mind
The parent trial (COcoa Supplement and Multivitamin Outcomes Study, COSMOS; NCT02422745) is a randomized clinical trial of cocoa extract supplement (containing a total of 500 mg/d flavanols, including 80 mg.
- Conditions
- Cognitive Impairment, Dementia, Aging
- Trial name
- COSMOS-Mind (NCT03035201)
- Where
- United States
- Volunteers
- 2,262 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Aging, Physical Functioning
Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository
The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in…
- Conditions
- Aging, Physical Functioning, Cognitive Functioning, Fitness
- Trial name
- PPS (NCT01720472)
- Testing
- Biomarker studies
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Aging, Mild Cognitive Impairment
China Longitudinal Aging and Cognitive Impairment Study
This is a multi-center longitudinal study that consists of five cohorts: cognitive normal aging (CN), Subjective cognitive impairment (SCI), mild cognitive impairment (MCI), Alzheimer's disease (AD) and vascular cognitive…
- Conditions
- Aging, Mild Cognitive Impairment, Alzheimer Disease, Neurodegeneration
- Trial name
- CLACIS (NCT05468905)
- Testing
- None of intervention
- Where
- 2 sites in China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Physical Inactivity, Aging
Motivating Activity Through Text Communications - Helping Adults Increase Movement
The goal of this clinical trial is to compare the effect of different types of text messages on physical activity levels of middle-aged and older adults and to determine whether these messages are effective in adults age 40 and…
- Conditions
- Physical Inactivity, Aging, Cognitive Ability, Behavior Change
- Trial name
- MATCH AIM (NCT07593677)
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Aging, Mild Cognitive Impairment
Implication of Cognitive Reserve in Non-pharmacological Intervention Outcomes
Cognitive reserve (CR) is defined as the gradual accumulation of neural resources and their adaptability (i.e., efficiency, capacity, flexibility) due to genetic and/or lifelong environmental factors that mitigate the cognitive…
- Conditions
- Aging, Mild Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT06563453
- Testing
- transcranial alternating current stimulation
- Where
- Czechia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Masaryk University