Clinical trials: Cognitive Aging
Cancer, Mental Health
Healthspan Connect Programme of Research
Healthspan Connect is a new research programme designed to understand what helps people stay healthy as they age. The programme will explore how lifestyle, environment, genetics, and social factors influence healthy ageing and…
- Conditions
- Cancer, Mental Health, Ageing Well, Resilience
- Trial name
- NCT07209774
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- King's College London
Aging
Pilot Intervention With Near Infrared Stimulation
The current study will test whether age-related cognitive and mood changes in older adults and those will be affected by near infrared (NIR) stimulation.
- Trial name
- NCT03551392
- Testing
- Medx Console System, Vielight 810 intranasal stand alone unit
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alzheimer Disease
Whole Egg Intake and Choline Concentration in the Aging Brain
By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status.
- Trial name
- NCT05021211
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Healthy Aging
Neuroathletic Exercise In The Elderly
Objective: The aim of this protocol study was to investigate the effect of neuroathletic exercise on walking speed, fall risk and cognitive function in the elderly.
- Trial name
- NCT07070336
- Testing
- Neuroathletic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Healthy Aging
Uncovering the Cognitive and Neural Mechanisms Underlying Cognitive Time
Time processing, the ability to process and encode temporal information, is essential for cognitive functioning and for a large number of daily life activities.
- Trial name
- TIMES (NCT06349213)
- Testing
- FDOPA injection before PET imaging, Time perception tasks, fMRI imaging
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aging
Acute Passive Heating in Healthy Older Adults
Aging is associated with a decline in cardiovascular health, cognitive function and losses in muscle strength, with half or more of those over age 65 suffering from two or more comorbidities (e.g., heart disease, type 2…
- Trial name
- NCT05622747
- Testing
- Passive heating
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Aging, Healthy
ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly
The purpose of the ACTIVE study was to test if cognitive training interventions could maintain functional independence in elders by improving basic mental abilities, with follow-up assessments through five years.
- Trial name
- ACTIVE (NCT00298558)
- Testing
- Cognitive Training
- Where
- 7 sites in United States
- Volunteers
- 2,832 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Aging
Evaluation of the Effects of the New Program for Cognitive Enhancement and Improvement in the Elderly
The purpose of this study is to investigate the effect of cognitive rehabilitation program on the improvement of cognitive functions in normal elderly subjects.
- Trial name
- NCT03401775
- Testing
- Cognitive rehabilitation program
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Aging, Alzheimer Disease
Tennessee Alzheimer's Project
The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals…
- Conditions
- Aging, Alzheimer Disease, Biomarker, Cognitive Dysfunction
- Trial name
- TAP (NCT05372172)
- Testing
- none, observational study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cognitive Decline, Healthy Aging
Non-invasive Brain Stimulation and Strategic Memory Training
Physiological aging is often associated with memory function decline. Recently, the use of transcranial direct current stimulation (tDCS), a type of non-invasive brain stimulation, has been combined with adaptive working memory…
- Trial name
- StMe-tDCS (NCT05929872)
- Testing
- Non-invasive brain stimulation
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Adherence, Treatment
Smart Reminders to Promote Home-based Cognitive Training
This study will examine whether among older adults an adaptive and personalized reminder system can better support adherence to home-based cognitive training over typical reminder systems.
- Trial name
- NCT05016856
- Testing
- Adherence Promotion With Person-centered Technology (APPT) System, Standard Reminder System (Active Control)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cognitive Aging
The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults
While an intellectually active and socially integrated lifestyle shows promise for promoting cognitive resilience, the mechanisms underlying any such effects are not well understood.
- Trial name
- MixedWM (NCT05672771)
- Testing
- Different Mixed Condition (DM), Different Single Condition (DS), Same Task (ST) Practice Control
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Sleep Disturbance, Cognitive Change
Integrating Systematic Data of Geriatric Medicine to Explore the Solution for Health Aging
This project aims to build up the comprehensive database of geriatric medicine for local Taiwanese.
- Conditions
- Sleep Disturbance, Cognitive Change, Aging
- Trial name
- NCT04207502
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease
TMS for Cognitive Decline in Aging and Preclinical AD
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical…
- Conditions
- Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
- Trial name
- NCT06956300
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Brain Aging
AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults
The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia.
- Trial name
- AvoCog (NCT06137339)
- Testing
- Avocado Group
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Physical Activity
Supervised Group-based Walking Intervention Among Inactive Older Adults in Saudi Arabia
The purpose of the proposed study is to compare the effects of supervised group-based walking and non-supervised individual-based walking interventions on frailty, cognitive function and quality of life among inactive older…
- Trial name
- NCT05151575
- Testing
- supervised group-based walking and non-supervised individual-based walking interventions
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Oxidative Stress, Healthy Aging
Efficacy of Solarplast for Health and Oxidative Stress
Solarplast is a unique mixture of antioxidant enzymes and single antioxidant molecules that are capable of attack oxidants that cause damage to the cells in the human body and cause premature aging.
- Conditions
- Oxidative Stress, Healthy Aging, Skin Health
- Trial name
- NCT04144777
- Testing
- Solarplast
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
Alzheimer's Disease
Imaging Inflammation in Alzheimer's Disease
This study is being done to learn about inflammation and amyloid in Alzheimer's disease. A type of brain scan called a PET scan is used measure 1) inflammation and 2) abnormal accumulation of a the amount of a certain protein…
- Trial name
- NCT02831283
- Testing
- 11C-PBR28, 18F-Florbetaben, Lumbar puncture (optional)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Patrick Lao
Cognitive Aging
Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
This proposal aims to determine whether low does of the alpha-2A-adrenoceptor agonist guanfacine can improve deficits in prefrontally-mediated cognitive functions in healthy elderly subjects.
- Trial name
- NCT00935493
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Yale University
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital