Clinical trials: Cognitive Deficits
Cognitive Decline, Aging
Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Markers in Ageing
COMBI is a multi-center, randomized controlled trial among 70 older adults at risk of cognitive decline. The main goal is to investigate the effect of a 6-week colon-delivered multivitamin supplementation on the gut-brain axis in…
- Trial name
- COMBI (NCT05675007)
- Testing
- Colon-delivered multivitamin supplement
- Where
- 2 sites in Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Falls, Fall Risk
The Relationship Between Self-Awareness and Risk of Falls During Walking in Adults
This study examines the relationship between self-awareness and the risk of falls during walking in older adults and rehabilitation patients. Falls are a major health concern among older adults worldwide.
- Conditions
- Falls, Fall Risk, Fall Risk Factors, Cognitive Dysfunction
- Trial name
- SAFR (NCT07367763)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Memory Disorders, Alzheimer Disease
Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGNISION™) as a Useful Cognitive Biomarker for Alzheimer's Disease.
The proposed study is designed to evaluate the performance of the COGNISION™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Memory Disorders, Alzheimer Disease, Dementia, Cognitive Impairment
- Trial name
- COGNISION™ (NCT00938665)
- Testing
- COGNISION™ System
- Where
- 7 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Neuronetrix, Inc.
Mild Cognitive Impairment
Biodistribution of [11C]Acetoacetate/[18F]Fluorodeoxyglucose in Subjects With Risk Factors for Alzheimer's Disease
This is a single center imaging study that will recruit 60 participants who are enrolled in the Effect of a Ketogenic Diet on Alzheimer's Disease Biomarkers and Symptoms: Brain Energy for Amyloid Transformation in AD (BEAT-AD)…
- Trial name
- AcAc PET (NCT03130036)
- Testing
- [11C]Acetoacetate[18F]Fluorodeoxyglucose positron emission tomography scan
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer Survivors
A Study of Attention and Memory Processes in Breast Cancer Survivors
The purpose of this study is to observe the attention and memory processes in breast cancer survivors. Both cancer survivors and healthy volunteers (who are the same age as the cancer survivors) will participate in this study so…
- Trial name
- NCT04883398
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Alzheimer's Disease, Mild Cognitive Impairment
Effectiveness of a Brain-Computer Interface Based System for Cognitive Enhancement in the Normal Elderly
The primary objective is to examine the efficacy of 8-weeks of a locally developed brain-computer interface based system (BrainpalTM)intervention for improving attention and memory in normal elderly.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Cognitive Decline, Dementia
- Trial name
- 3ECog (NCT01661894)
- Testing
- BrainPalTM
- Where
- Singapore
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Mild Cognitive Impairment
Transcranial Direct Current Stimulation to Enhance Cognition in Mild Cognitive Impairment
The study will examine whether the effects of computerized brain training are enhanced when training is combined with mild brain stimulation in patients with mild cognitive impairment.
- Trial name
- NCT01653431
- Testing
- Transcranial direct current stimulation
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Cognitive Impairment, Cognitive Decline
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- AIM (NCT05998031)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
IgA Nephropathy (IgAN)
Exploring the Brain - Gut Microbiota - Kidney Interactive Damage Mechanisms Underlying Cognitive Decline in Patients With IgA Nephropathy Using Ultra-high Field Magnetic Resonance Imaging
IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. Its progression is often accompanied by cognitive decline, manifesting as multi-dimensional cognitive deficits in areas such as memory, attention…
- Trial name
- NCT07617402
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Progesterone, Estrogens
Neural Changes in the Aging Auditory System
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.
- Conditions
- Progesterone, Estrogens, Hearing, Psychoacoustics
- Trial name
- NCT00264407
- Testing
- Hormone Replacement Therapy - HRT
- Where
- 2 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Frail Elderly Syndrome
HOPE (Healthy Older People Everyday) To Age in Place
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment, falls in older adults carry an increased risk for poor health outcomes and if identified early, can be prevented…
- Trial name
- NCT03797352
- Testing
- Multicomponent exercise
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Mild Cognitive Impairment, Older Adults at High Risk for MCI
The Impact of 6-months of Resistance Training on Brain and Muscle Health in Older Adults With MCI
The goal of this clinical trial is to learn about the effect of long resistance training intervention on brain and muscle health in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT06252844
- Testing
- Resistance exercise training, Active control
- Where
- 2 sites in Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Cognitive Dysfunction
Study on the Effectiveness of the MTT24.5 Cognitive Training Program on Cognitive Skills, Brain Volume, and Activation
The goal of this study is to evaluate the effectiveness of a cognitive training program called Mental Training Tech 24.5 (MTT24.5).
- Trial name
- MTT245Cog (NCT06549517)
- Testing
- Cognitive training
- Where
- Argentina
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institute for Biomedical Research, CONICET
Ageing, Frailty
Physiotherapy Interventions on Functional Capacity, Balance and Mental Domains in Community-Dwelling Older Adults: A Randomized Clinical Trial With Two Parallel Groups
This study will investigate whether two different physiotherapy exercise programs can improve physical function, balance and mental well-being in older adults living in the community in Angola.
- Conditions
- Ageing, Frailty, Sarcopenia, Decline, Cognitive
- Trial name
- NCT07424274
- Testing
- Multicomponent Physiotherapy Exercise Program, Reduced Functional Physiotherapy Exercise Program
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Dementia, Neurodegenerative Disease
VR-based Physical Activity and Reminiscence Therapy
The goal of this clinical trial is to learn if active Physical activity + virtual reality cognitive therapy (aPAVRCT) works to slow the progression of AD cognitive decline in older adults.
- Conditions
- Dementia, Neurodegenerative Disease, Mild Cognitive Impairment (MCI), Virtual Reality
- Trial name
- NCT06934720
- Testing
- aPAVRCT
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
Atherosclerosis, Vascular Disease
The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing
The purpose of this study is to determine if folic acid supplementation can slow down atherosclerotic progression, age-related cognitive decline and age-related hearing loss.
- Conditions
- Atherosclerosis, Vascular Disease, Cognitive Decline, Hearing Loss
- Trial name
- NCT00110604
- Testing
- folic acid (0.8 mg)
- Where
- Netherlands
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Traumatic Brain Injury, Cognitive Impairment
Rehabilitation of Working Memory and Brain Plasticity After Traumatic Brain Injury: Plastim-MDTC
The aim of this study is to assess the brain correlates, as assessed with multimodal MRI, of working memory training in patients with severe traumatic brain injury (TBI)
- Trial name
- Plastim-MDTC (NCT03513133)
- Testing
- working memory training
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Cognition Disorder, Healthy
The Development of Categorization
It is commonly believed that objects in the world can be categorized in at least three different ways or levels. The three levels are basic, superordinate, and subordinate.
- Trial name
- NCT00001950
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Age-related Cognitive Decline
Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance
The primary purpose of this study is to apply state-of-the-art Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) techniques to measure changes over time in the brain.
- Trial name
- NCT01120860
- Testing
- MRI
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Dementia, Potentially Inappropriate Medication Use
e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most
The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational…
- Conditions
- Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
- Trial name
- e-ALIGN (NCT07454824)
- Testing
- e-ALIGN Patient-Portal Deprescribing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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