Clinical trials: Cognitive Enhancement
Gamma Oscillations, Healthy Adults
Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement
This study aims to evaluate whether personalized gamma-frequency auditory stimulation enhances cognitive function and brain synchronization.
- Conditions
- Gamma Oscillations, Healthy Adults, Alzheimer's Disease (AD), Gamma Entrainment Using Sensory Stimuli (GENUS)
- Trial name
- NCT07690865
- Testing
- Personalized optimal gamma auditory frequency stimulation, Non-optimal gamma auditory frequency stimulation
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Aging, Physical Activity
A 12-week Intervention With Motivational Interviewing and Physical Activity Monitoring, to Enhance the Daily Amount of Physical Activity in Community Dwelling Older Adults - a Randomized Controlled Trial
To investigate if motivational-interviewing will enhance the expected effect from physical activity monitors, on physical activity in older adults, we will conduct a two-arm randomized controlled trial in 2019.
- Conditions
- Aging, Physical Activity, Older Adults
- Trial name
- MIPAM (NCT03906162)
- Testing
- Motivational interviews, Base intervention
- Where
- Denmark
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Schizophrenia
Cognitive Enhancement Therapy for Early-Stage Schizophrenia
This study will determine the effectiveness of cognitive enhancement therapy (CET) in treating cognitive abnormalities in people experiencing the early stages of schizophrenia.
- Trial name
- NCT00167362
- Testing
- Cognitive enhancement therapy (CET), Enriched supportive therapy (EST)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Multiple Sclerosis, Performance Enhancement
Effects of DHA in Patients With Multiple Sclerosis
This clinical trial will investigate the effects of combining therapeutic exercise with DHA supplementation in 100 patients with multiple sclerosis using a randomized controlled design.
- Conditions
- Multiple Sclerosis, Performance Enhancement, Supplemental Nutrition Assistance Program Education, Strength Outcomes
- Trial name
- DHAME (NCT07346703)
- Testing
- Docosahexaenoic Acid (DHA) Dietary Supplement, Sunflower Oil
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Aging
Improvement in Memory With Plasticity-Based Adaptive Cognitive Training (IMPACT)
The primary objective of this study is to evaluate the effects of a computer-based training program on the memory and cognitive abilities of mature individuals undergoing healthy aging.
- Trial name
- IMPACT (NCT00283010)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Educational DVDs
- Where
- United States
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Smoking
Youth Smoking Cessation: Therapy +/- "The Patch"
Reducing tobacco use by adolescents is a national health priority. In recent polls, most adolescent smokers reported having tried unsuccessfully to quit.
- Trial name
- NCT00631020
- Testing
- CBME, Optional NRT
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cognitive Performance, Physical Performance Enhancement
Effects of Caffeine and L-Theanine on Physical and Cognitive Performance in Trained Athletes
The aim of this clinical trial is to examine how caffeine and L-theanine, taken alone or together, affect both physical and cognitive performance in healthy, trained athletes.
- Conditions
- Cognitive Performance, Physical Performance Enhancement, Caffeine and L-theanine Interaction
- Trial name
- NCT07268573
- Testing
- Caffeine, L-theanine, Combined Caffeine and L-Theanine
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ulaş Can YILDIRIM
Healthy Aging
Using Teleneuropsychology to Optimize Cognition in Healthy Aging: the Web-based Breakfast Game
Executive control processes involve initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior.
- Trial name
- NCT05506852
- Testing
- Web-based training strategy, Web-based regular training (no strategy)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Columbia University
Aging
Evaluation of the Effects of the New Program for Cognitive Enhancement and Improvement in the Elderly
The purpose of this study is to investigate the effect of cognitive rehabilitation program on the improvement of cognitive functions in normal elderly subjects.
- Trial name
- NCT03401775
- Testing
- Cognitive rehabilitation program
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Healthy Adults
The Feasibility of TECH: Tablet Enhancement of Cognition and Health for Healthy Adults
This study assess the feasibility of novel cognitive intervention utilizing tablet apps (TECH protocol: Tablet Enhancement of Cognition and Health) in terms of relevance, adherence, suitable challenges, training time etc.
- Trial name
- NCT02955303
- Testing
- TECH: Tablet Enhancement of Cognition and Health
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Cognitive Change, Development, Adolescent
Enhancement of Learning and Memory Following Supplementation With Juice PLUS+® OMEGA in an Adolescent Population
This study aims to investigate the effect of chronic supplementation with a commercially available, plant-derived, omega-3 intervention and cognitive performance in adolescent participants aged 13-14 years.
- Trial name
- AdCog-O (NCT05581108)
- Testing
- Juice PLUS+® OMEGA
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Reading
Sleep Disturbance, Dementia
Sleep Enhancement for Older Adults Living With Memory Loss And Their Care Partners
The purpose of this study is to determine if a 6-week videoconference intervention to teach skills to improve sleep is practical, acceptable, and helpful to persons living with memory loss, cognitive impairment, and/or dementia…
- Trial name
- SLEEPMATE (NCT06250725)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Emory University
Physical Functional Impairment, Cognitive Impairment
Community Recreation to Enhance Function in Aging
This aim of this study is to examine the therapeutic impacts of a group-based recreational program that delivers guided visual artmaking and dual-task exergaming, to older adults.
- Trial name
- NCT07104435
- Testing
- Artmaking and exergaming
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Healthy
Acute Berry Intake on Metabolic Control and Cognitive Function
The objectives of this study are: 1. Evaluate the effects of acute dietary raspberry intake on metabolic-associated impairments in cognitive and psychomotor function in overweight/obese adults (55-70y) following a meal challenge…
- Trial name
- RRB3 (NCT03879213)
- Testing
- Active breakfast, Control breakfast
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Reaction Time, Alertness
tFUS to Enhance Alertness and Performance
The investigators goal is to target FUS energy to the centromedian nucleus of the thalamus (CMT), the core of arousal, which is inaccessible by traditional non-invasive neuromodulation devices.
- Trial name
- NCT06461221
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Memory, Learning
Cognitive, Emotional, Physical and Psychosocial Effects of Panax Quinquefolius L
The purpose of this study is to determine the efficacy and safety of REMEMBER-fX (HT1001, an extract of Panax quinquefolius) in a human sample using standard clinical neuropsychological instruments and side effects rating scales.
- Conditions
- Memory, Learning, Attention, Cognition
- Trial name
- REMEMBER-fX (NCT00527969)
- Testing
- HT1001 extract of Panax quinquefolius L
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- CV Technologies
Resilience, Cognitive Function and Well-Being
Aging Resilience Through Microbiota Optimization and Regulation
Sarcopenia, characterized by the progressive loss of muscle mass and strength in older adults, is a key factor in health deterioration.
- Conditions
- Resilience, Cognitive Function and Well-Being, Muscle Function, Handgrip Strength Test, Insulin Sensitivity
- Trial name
- ARMOR (NCT06649981)
- Testing
- FMT capsule
- Where
- 2 sites in Chile
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gonzalo Jorquera, PhD
Cognitive Decline, Cerebrovascular Function
Resistance Training and Neuroimaging
Aging tends to compromise the ability to solve problems, remember details, and process information. At the extreme level, this normal cognitive decline can interfere with independent living.
- Trial name
- RTNI (NCT03982550)
- Testing
- Periodized Resistance Training
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Todd Schroeder
Cognition
Investigating the Effects of a Haskap Berry Supplement on Cognitive Health
This study aims to investigate the postprandial (2h) and longer term (4 week) effects of a haskap berry supplement on cognitive, vascular, and metabolic function in healthy ageing adults aged 50+.
- Trial name
- HACVAC (NCT07119788)
- Testing
- Pure haskap berry powder, Vitamin-and mineral-enhanced haskap berry powder
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Reading