Clinical trials: Cognitive Therapy
Major Depressive Disorder
CBT+ for Depression
This study investigates the effects of a novel intervention approach, intentionally sequencing aerobic exercise immediately prior to therapy sessions (i.e., cognitive behavioral therapy [CBT]) to determine its effects on both…
- Trial name
- CBT+ (NCT06001346)
- Testing
- ActiveCBT, CalmCBT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Sturge-Weber Syndrome
Novel Cognitive Treatment Targets for Epidiolex in Sturge- Weber Syndrome
The purpose of this study is to better understand the utility of cannabidiol (CBD/ Epidiolex) for improving the treatment of cognitive impairments in Sturge-Weber syndrome (SWS).
- Trial name
- NCT04447846
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Anne Comi, MD
Atherosclerosis
ELITE: Early Versus Late Intervention Trial With Estradiol
The purpose of this study is to examine the effects of oral 17B-estradiol (estrogen) on the progression of early (subclinical) atherosclerosis and cognitive decline in healthy postmenopausal women.
- Trial name
- NCT00114517
- Testing
- 17B-estradiol
- Where
- United States
- Volunteers
- 643 people, healthy volunteers welcome
- Sponsor
- University of Southern California
PTSD
A Comparison of Cognitive Processing Therapy (CPT) Versus Present Centered Therapy (PCT) for Veterans
The purpose of this study is to compare the effectiveness of Cognitive Processing Therapy (CPT) versus Present Centered Therapy (PCT) for male OEF/OIF Veterans with combat related PTSD.
- Trial name
- NCT00607815
- Testing
- Cognitive Processing Therapy, Present Centered Therapy
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Headache
Naratriptan for the Treatment of Post Traumatic Headache Associated With Cognitive Dysfunction
The purpose of this study is to determine whether naratriptan, a medication approved for treatment of migraine, is effective in the treatment of post traumatic headache associated with cognitive dysfunction.
- Trial name
- NCT00487578
- Testing
- naratriptan HCl
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cady, Roger, M.D.
Huntington Disease
Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease
This is a double-blind, placebo-controlled 2-period 10-week treatment within-subject crossover study of neflamapimod in early-stage Huntington disease (HD).
- Trial name
- NCT03980938
- Testing
- neflamapimod
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- EIP Pharma Inc
Depression, Major Depressive Disorder
eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk
This pilot randomized controlled trial seeks: (1) to determine the preliminary efficacy of our modernized collaborative care intervention for depression in improving the diabetes risk markers of hemoglobin A1c and insulin…
- Conditions
- Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms
- Trial name
- NCT04437485
- Testing
- Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Indiana University
Adolescents, Mood Disorders
Mobile-enhanced Group CBT for Adolescents at Risk Severe Mood Disorders
Although cognitive-behavioral therapy (CBT) has shown efficacy in reducing symptoms and rates of mood relapse in adolescents at high risk for severe mood disorders (SMD; i.e., bipolar I/II disorder and recurrent or unremitting…
- Trial name
- NCT04887155
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of California, Los Angeles
HIV
A Cognitive Behavioral Therapy Group Intervention to Increase HIV Testing and PrEP Use Among Latinx Sexual Minority Men
This study consists of a randomized controlled trial (RCT) of a multi-session cognitive behavior therapy (CBT) group intervention that aims to improve HIV outcomes by increasing adaptive, effective coping responses to stigma from…
- Trial name
- NCT04225832
- Testing
- CBT Coping Intervention
- Where
- United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- RAND
Insomnia
Comparing Internet and In-Person Brief Cognitive Behavioral Therapy of Insomnia
The objective of this study is to directly compare 6 sessions of in-person and Internet administered Cognitive-Behavior Therapy for Insomnia (CBTi) to a Minimal Contact control (MC), within an active duty military population to…
- Trial name
- NCT01549899
- Testing
- In-person Cognitive Behavioral Therapy of Insomnia, Internet Cognitive Behavioral Therapy of Insomnia
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Daniel J. Taylor, Ph.D.
Mild Cognitive Impairment, Herpes Simplex 1
Valacyclovir for Mild Cognitive Impairment
Anti-viral treatment in Mild Cognitive Impairment (MCI) is a Phase II, placebo-controlled, 52-week trial using oral valacyclovir 4 g/day in 50 HSV seropositive, AD biomarker-positive, amnestic mild cognitive impairment (MCI)…
- Conditions
- Mild Cognitive Impairment, Herpes Simplex 1, Herpes Simplex 2
- Trial name
- VALMCI (NCT04710030)
- Testing
- Valacyclovir hydrochloride 500mg caplet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer Disease
BI 409306 in Patients With Cognitive Impairment Due to Alzheimer's Disease.
The study is designed to compare the effects of BI 409306 compared to placebo in patients with cognitive impairment due to Alzheimer's Disease
- Trial name
- NCT02337907
- Testing
- BI 409306, Donepezil
- Where
- 60 sites in United States, Austria and 9 more
- Volunteers
- 329 people
- Sponsor
- Boehringer Ingelheim
Dementia, Cognitive Impairment
LifeBio Memory Digital Reminiscence Platform
Non-pharmacological interventions and person-centered care strategies are important elements of care for people with Alzheimer's disease and related dementias.
- Trial name
- NCT04769466
- Testing
- LifeBio Memory
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Benjamin Rose Institute on Aging
Posttraumatic Stress Disorder
Group Based Exposure Therapy for Combat-Related PTSD
The purpose of this randomized controlled trial is to determine if Group Based Exposure Therapy (GBET) is more effective than treatment as usual in reducing the symptoms of war-related Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT00535223
- Testing
- Group Based Exposure Therapy, Present Centered Group Therapy
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- US Department of Veterans Affairs
Migraine Headache
TelemEdiciNe-bAsed Cognitive TherapY for Migraines
The goal of this pilot study is to evaluate a bundle of implementation strategies at three Veteran Affairs Medical Centers (VAMCs) to facilitate the referral and adoption of a telehealth based, cognitive behavioral therapy…
- Trial name
- TENACITY (NCT04613362)
- Testing
- TENACITY Telehealth Cognitive Behavioral Therapy for Migraine, Behavioral Usual Care
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Insomnia, Chronic Pain
A Cognitive-Behaviour Therapy (CBT) Self-Management Approach for Insomnia in Chronic Pain: A Randomized Control Trial
This study will test the impact of a cognitive-behavioural self-management approach for the management of insomnia among patients with chronic pain.
- Trial name
- NCT01188460
- Testing
- Self-help manual for insomnia, Sleep diary
- Where
- 2 sites in Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Prostate Cancer, Mild Cognitive Impairment
PET Imaging in MCI Following ADT for PCa
Mild cognitive impairment (MCI) with ageing is thought in part to be related to reduced serum sex hormones which is well-recognized, especially in females, but poorly understood.
- Trial name
- NCT02061345
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Imperial College London
Chronic Pain, Low Back Pain
Meditation-CBT for Opioid-treated Chronic Low Back Pain
Chronic low back pain (CLBP) is one of the most common, costly and disabling conditions. It is often refractory to treatment, with patients requiring long-term opioid therapy.
- Trial name
- NCT01775995
- Testing
- Meditation-CBT Intervention + Usual Care, Usual Care Alone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Wisconsin, Madison
Major Depressive Disorder, Dysthymic Disorder
Cognitive Therapy for Unipolar Depression: Efficacy of a Dilemma-Focused Intervention
The purpose of this study is to determine the efficacy of a brief psychological intervention focused on the personal dilemmas identified for each depressive patient.
- Trial name
- NCT01542957
- Testing
- Combined Cognitive Behavioral and Dilemma-Focused Therapy, Cognitive Behavioral Therapy for Depression
- Where
- 4 sites in Spain
- Volunteers
- 128 people
- Sponsor
- University of Barcelona
Prolonged Grief Symptoms
Ericksonian Hypnosis Versus CBT for Prolonged Grief
Effects of Ericksonian Hypnotherapy Versus Cognitive Behavioral Therapy on Prolonged Grief Among University Students in Istanbul: A Randomized None-clinical Controlled Trial This randomized controlled trial explores the efficacy…
- Trial name
- NCT06398886
- Testing
- Ericksonian Hypnosis, Cognitive Behavioral Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University