Clinical trials: Community-Acquired Infection
Community Acquired Pneumonia
The Establishment and Improvement of Community Acquired Pneumonia Monitoring and Disposal Network in Beijing
In the 21st century, threats to human health of new respiratory infectious diseases increased. The project aim is to establish pneumonia pathogens network in Beijing and understand the pathogen spectrum distribution.
- Trial name
- NCT01236677
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Capital Medical University
Pneumonia, Bacterial
Diagnostic Accuracy of Infection Biomarkers in the Initial Investigation of Patients With Suspected Pneumonia
The aim of this study is to investigate the diagnostic and prognostic value of C-reactive protein (CRP), serum procalcitonin (PCT) and soluble urokinase plasminogen activator receptor (suPAR) in the initial investigation of…
- Trial name
- NCT04652167
- Testing
- PCT, suPAR, Standard care
- Where
- Denmark
- Volunteers
- 411 people
- Sponsor
- University of Southern Denmark
HIV/AIDS
Changing Health Through Food Support (CHEFS) Program
UCSF and Project Open Hand (POH), a community based organization in San Francisco which provides meals and groceries to chronically ill clients in the Bay Area, have partnered to conduct an initial randomized controlled trial…
- Trial name
- CHEFS (NCT03191253)
- Testing
- Medically-appropriate meals and groceries
- Volunteers
- 191 people
- Sponsor
- University of California, San Francisco
Community Acquired Pneumonia
A Phase III Study of Faropenem in the Treatment of Adult Community-acquired Bacterial Pneumonia
The purpose of this study is to evaluate the safety and Efficacy of Faropenem in community-acquired pneumonia (CAP) subjects
- Trial name
- NCT01937832
- Testing
- Faropenem, Ertapenem
- Where
- 7 sites in China
- Volunteers
- 540 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS)
Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia
This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis…
- Conditions
- Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS), Sepsis, Lymphopenia
- Trial name
- NCT07492875
- Testing
- Nogapendekin alfa inbakicept (NAI), agenT-797
- Sponsor
- ImmunityBio, Inc.
Pneumonia
A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Mild to Moderate Pneumonia in Adult Patients
The study was performed to see if a single, 2.0-g oral dose of azithromycin sustained release (SR) was at least as effective as a 7-day regimen of levofloxacin (500 mg once daily) for the treatment of mild to moderate…
- Trial name
- NCT00643734
- Testing
- azithromycin sustained release, levofloxacin
- Where
- 65 sites in United States, Canada and 6 more
- Volunteers
- 468 people
- Sponsor
- Pfizer
Asthma, COPD
Exhaled Breath Metabolomic Biomarkers in the Acutely Breathless Patient
An acute study carried out across three acute admissions units within Leicestershire. The study is aimed at discovery and validation of volatile organic compounds (VOCs) in exhaled breath.
- Conditions
- Asthma, COPD, Heart Failure, Community-acquired Pneumonia
- Trial name
- EMBER (NCT03672994)
- Where
- United Kingdom
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Use of Research Evidence
Effects of an Evidence Service on Community-based AIDS Service Organizations' Use of Research Evidence
The investigators have developed an online database called 'Synthesized HIV/AIDS Research Evidence' (SHARE), which is designed to support the use of research evidence by those working in the HIV/AIDS sector.
- Trial name
- NCT01257724
- Testing
- SHARE (Synthesized HIV/AIDS Research Evidence)
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ontario HIV Treatment Network
HIV Infection
Same-day ART Initiation Versus Standard of Care After Positive HIV-test Result in Rural Lesotho
The CASCADE-trial is a two-armed open-label randomized controlled trial conducted in rural Lesotho. Participants who were tested HIV-positive during community-based HIV testing and counseling campaigns are randomized to the…
- Trial name
- CASCADE (NCT02692027)
- Testing
- Same-day ART initiation, Standard of care
- Where
- Lesotho
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute
HIV Infections
C2P (With Venues): Connect to Protect® Partnerships For Youth Prevention Interventions
During Phase III, Adolescent Trials Network for HIV/AIDS Interventions (ATN)/Connect-to-Protect (C2P) site staff, their official community partners established in Phase I, and newly invited community sector representatives (i.e.…
- Trial name
- NCT00271908
- Testing
- Community Mobilization
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 4,472 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hiv
COMMIT HIV Trial Nepal
Community Healthcare Workers (CHWs), who live in the communities they serve, have the potential to reach patients who poorly engage in their care.
- Trial name
- NCT04462679
- Testing
- COMMIT mHealth application
- Where
- Nepal
- Volunteers
- 86 people
- Sponsor
- Possible
Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum
Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS)
This Phase 2 study tests whether adding two immune therapies - nogapendekin alfa-inbakicept (NAI) and off-the-shelf iNKT cell infusions - to standard care can safely help critically ill adults with severe community-acquired…
- Conditions
- Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum, Sepsis, Lymphopenia / Immunoparalysis in Critically Ill Adults
- Trial name
- NCT07492888
- Testing
- Nogapendekin Alfa-Inbakicept (NAI), Allogeneic invariant Natural Killer T (iNKT) Cells (AgenT-797)
- Sponsor
- ImmunityBio, Inc.
Community Acquired Pneumonia in Children, Antibiotic Stewardship
Antibiotic Prescription in Children Hospitalized for Community-acquired Pneumonia
A study to observe how often antibiotics are prescribed in children hospitalized for pneumonia and how doctors decide if a child needs antibiotics or not. Parent satisfaction will also be recorded.
- Trial name
- NCT04681339
- Testing
- Antibiotic treatment, No antibiotic treatment
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Pneumonia
A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting
The purpose of this study is to learn about how well the 20-valent pneumococcal conjugate vaccine (20vPnC) works against radiologically-confirmed community-acquired pneumonia (RAD+CAP) due to the 7 new serotypes (types of a…
- Trial name
- NCT05452941
- Testing
- Diagnostic test on urine samples
- Where
- 54 sites in United States, Israel and 1 more
- Volunteers
- 12,500 people
- Sponsor
- Pfizer
Community Acquired Pneumonia, Bronchiolitis
HVNI vs CPAP in Children With Acute Respiratory Distress
Acute breathing problems are a common reason for children to be admitted to the pediatric intensive care unit, and many of these children need breathing support without a breathing tube.
- Trial name
- P-HVNI-CPAP (NCT07336121)
- Testing
- High Velocity Nasal Insufflation (HVNI), Nasal Continuous Positive Airway Pressure (Nasal CPAP)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Community-Acquired Pneumonia, Vitamin a
The Effect of Adjunct Vitamin a on Community-Acquired Pneumonia in Southern Iranian Children: a Randomized Clinical Trial
This randomized clinical trial included 105 children with CAP who were admitted to Bandar Abbas Children's Hospital. Participants were randomly assigned to two groups: a control group receiving standard antibiotic therapy and an…
- Trial name
- CAP Vitamin A (NCT06677684)
- Testing
- Vitamin A
- Where
- Iran
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hormozgan University of Medical Sciences
Community-acquired Pneumonia
Clinical Study of Anerning Particle for the Treatment of Childhood Community-acquired Pneumonia
The purpose of this study is to evaluate the efficacy, safety and whether it can reduction of antibiotic use in the treatment of community-acquired pneumonia in children with Anerning granules combined with ceftriaxone sodium.
- Trial name
- NCT03675178
- Testing
- Anerning particle, control group
- Volunteers
- 216 people
- Sponsor
- China Academy of Chinese Medical Sciences
Community Acquired Pneumonia, Bacterial Pneumonia
Study Evaluating Tigecycline vs Levofloxacin in Hospitalized With Community-Acquired Pneumonia
To compare the efficacy and safety of tigecycline with those of levofloxacin in the treatment of subjects with CAP requiring hospitalization.
- Conditions
- Community Acquired Pneumonia, Bacterial Pneumonia, Cross Infection
- Trial name
- NCT00079885
- Testing
- tigecycline
- Volunteers
- 430 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Pneumonia
A Phase III Study to Evaluate the Safety, Efficacy and Pharmacokinetics/Pharmacodynamics of BAYQ3939 in Patients With Bacterial Pneumonia
The main objective of this study is to investigate the safety, pharmacokinetics (PK) and the relationship between PK and pharmacodynamics (Minimum Inhibitory Concentration [MIC] and Mutant Prevention Concentration [MPC]) of…
- Trial name
- NCT01561794
- Testing
- Ciprofloxacin (Cipro, BAYQ3939)
- Where
- 20 sites in Japan
- Volunteers
- 44 people
- Sponsor
- Bayer
Community-Acquired Infections
Role of Beta-blockers in the Prevention on the Arisen of a Severe Sepsis (TESS)
The severe sepsis (SS) and toxic shock (TS) are both frequent and severe complications of infectious diseases. They are one of the top ten causes of death in industrialized countries.
- Trial name
- NCT01606631
- Where
- 9 sites in France
- Volunteers
- 2,444 people
- Sponsor
- Rennes University Hospital