Clinical trials: Complex Intervention
Atherosclerosis, Cognitive Decline
Advancing Postmenopausal Preventive Therapy
Advancing Postmenopausal Preventive Therapy (APPT) is a randomized, double-blinded, placebo-controlled trial designed to determine the effects of tissue selective estrogen complex (TSEC) therapy on the progression of subclinical…
- Trial name
- APPT (NCT04103476)
- Testing
- Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Adult Caregivers of Individuals With TSC, Tuberous Sclerosis Complex (TSC)
TANDem-2: Closing the Gap to Interventions for TAND
The goal of this pilot study is to determine the feasibility, acceptability and impact of a brief behavioral intervention - the "Well-Beans for Caregivers" program, for adult caregivers of individuals with tuberous sclerosis…
- Trial name
- TANDem-2 (NCT06879665)
- Testing
- Well-Beans for Caregivers Program
- Where
- 2 sites in United States, Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Caregiver, Mindfulness
Resourcefulness Training and Decentering on Self-Management in Caregivers of Technology Dependent Children
The investigators will conduct a randomized clinical trial pilot study to examine the effectiveness of a theoretically based intervention (called ReMind) encompassing two key components: (a) Resourcefulness Training for parent…
- Conditions
- Caregiver, Mindfulness, Mechanical Ventilation Pressure High, Gastrostomy
- Trial name
- NCT02993887
- Testing
- Resourcefulness Training, Mindfulness
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Skin Laxity, Skin Roughness
Aesthetic Performance and Tolerance of an Injective Intradermal Treatment for the Skin Roughness and Laxity of Back of the Hands
People lose collagen all over the body, not just in the face; skin roughness and laxity of the dorsum of the hands can result from chrono and photo-aging.
- Trial name
- NCT05590364
- Testing
- Profhilo® Body
- Where
- Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- IBSA Farmaceutici Italia Srl
Breastfeeding, Breastfeeding, Exclusive
Breastfeeding - a Good Start Together
The Breastfeeding - a Good Start Together intervention study aims to increase the proportion of women who breastfeed for four and six months, and proportionately more in a group of women who are in risk of early breastfeeding…
- Trial name
- NCT05311631
- Testing
- Breastfeeding support
- Where
- 21 sites in Denmark
- Volunteers
- 5,010 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Health Behavior, Health-Related Behavior
Preventive Remediation for Optimal MEdical StudentS (PROMESS)
Medical students are under a great deal of competitive pressure throughout their training. During their studies, medical students experience high levels of stress, sleep disorders and excessive physical inactivity.
- Trial name
- PROMESS (NCT06309771)
- Testing
- Stress management, sleep improvement and fatigue reduction, sedentary behaviors reduction and physical activity promotion.
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Research on Healthcare Performance Lab U1290
Emotional Distress
Mindfulness Interventions and Emotional Distress: A Daily Study
This study hopes to explore whether the changes in rumination exhibited in Daily Diary mediates the effects of mindfulness intervention on alleviating emotional distress
- Trial name
- NCT06785259
- Testing
- Mindfulness Intervention for Emotional Distress(MIED)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University
COPD, Asthma
A Study Into Airways Disease Case Finding and Management
Chronic Obstructive Pulmonary Disease (COPD) is a disease of the lungs which is generally caused by smoking tobacco. It is a largely preventable disease that causes severe and irreversible damage to the lungs.
- Trial name
- ASSIST (NCT03355677)
- Testing
- Case finding Clinic, At Risk Case Clinics, Usual Care
- Where
- United Kingdom
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Bleeding, Blood Loss, Surgical
PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding
This will be the first prospective randomized controlled clinical trial directly comparing Prothrombin Complex Concentrate (PCC) Compared to Fresh Frozen Plasma (FFP) for post cardiopulmonary bypass microvascular bleeding and…
- Conditions
- Bleeding, Blood Loss, Surgical, Cardiovascular Surgical Procedures, Prothrombin Complex Concentrates
- Trial name
- NCT02557672
- Testing
- Prothrombin complex concentrate (Human), Fresh frozen plasma (FFP)
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mediation
Study of the Conditions of the Effects of Health Mediation on Underserved Population
The investigators are conducting a longitudinal mixed-method intervention study with a multi-center, multi-case explanatory sequential design.
- Trial name
- ECEMSo (NCT06180746)
- Testing
- Knowledge mobilization to facilitate the structuring of health mediation
- Where
- France
- Volunteers
- 1,041 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Iodine Deficiency
EUthyroid2: the Next Step Towards the Elimination of Iodine Deficiency and Preventable Iodine-related Disorders in Europe
In EUthyroid2 intervention measures are to be developed, implemented in ambulatory care settings and evaluated to effectively raise awareness for the risks of iodine deficiency among young women (18-24 years) in three European…
- Trial name
- EUthyroid2 (NCT06769009)
- Testing
- Educational intervention measures on iodine, iodine deficiency and iodine intake
- Where
- 6 sites in Bangladesh, Norway and 3 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- EUthyroid
Patient Satisfaction, Nurse's Role
Effects of Nursing Patient Handover
This study was planned in a quasi-experimental design, focusing on the feasibility, evaluation, and implementation of patient handover between nurses, and the effect of interventions to increase their effectiveness on the…
- Trial name
- NCT06468631
- Testing
- Complex Nursing Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Pre-Eclampsia, Gestational Diabetes
SMARThealth Pregnancy: Feasibility & Acceptability of a Complex Intervention for High-risk Pregnant Women in Rural India.
Background: Pregnancy-related conditions including hypertensive disorders of pregnancy (HDPs) and gestational diabetes mellitus (GDM) carry independent risks for future cardiovascular disease in women.
- Conditions
- Pre-Eclampsia, Gestational Diabetes, Anemia
- Trial name
- NCT03968952
- Testing
- SMARThealth Pregnancy
- Where
- India
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Dementia, Alzheimer Disease
Learning Skills Together Family Caregiver Complex Intervention
Learning Skills Together (LST) is a 6-week psychoeducational intervention focused on complex care (nursing) tasks completed by family caregivers to persons living with Alzheimer's Disease and related dementias.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burden, Self Efficacy
- Trial name
- LST (NCT05846984)
- Testing
- Learning Skills Together Intervention, Caregiver Healthy Living Intervention
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Health Services, Comorbidity
Ambulatory ICU Study for Medically and Socially Complex Patients
This is a prospective randomized wait-list control study to determine whether a stand-alone, co-located team of physician, mental health behaviorist, and care coordinators with decreased panel size (aka "intensive primary care")…
- Conditions
- Health Services, Comorbidity, Primary Health Care
- Trial name
- SUMMIT (NCT03224858)
- Testing
- SUMMIT intervention, Enhanced usual care
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Potentially Avoidable Hospitalisations
Implementation and Evaluation of a Complex Intervention to Reduce Avoidable Transitions Between Nursing Home and Hospital
Hospital admissions can have a negative impact on the physical and emotional health of nursing home residents. Although evidence-based interventions have been developed to reduce hospitalisations, the evidence regarding their…
- Trial name
- RATHER-NH (NCT07359521)
- Testing
- RATHER-NH Toolkit
- Where
- 6 sites in Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Arthroplasty, Replacement, Hip
The Effect of Spouses' Involvement Through Case Management in Older Patients' Fast-track Program
Patients in fast-track programmes are required to take an active part in their treatment and rehabilitation. Spouses of older patients can often provide valued practical and emotional support, reducing stress, pain and length of…
- Trial name
- SICAM (NCT02561637)
- Testing
- Case management, Control group
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Health Behavior, Health Promotion
Complex Multiple Risk Behavior Intervention in People Between 45 to 75 Years (EIRA Study)
This study examines the effectiveness and the costs of a complex multiple risk behavior intervention to promote healthy behaviors in people aged between 45 and 75 years attended in Primary Health Care services.
- Conditions
- Health Behavior, Health Promotion, Primary Health Care, Implementation Research
- Trial name
- EIRA (NCT03136211)
- Testing
- EIRA intervention
- Where
- Spain
- Volunteers
- 3,062 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Skin Aging
Effectiveness and Safety of Collagen Complex COLLOST in Anti-age Therapy
This study evaluates the statistics of anti-age treatment in outpatient sites in Russia (involution indicators: clinical scales; instrumental diagnostics, ultrasonic scannings, assesment of allergic state, efficacy assesment in…
- Trial name
- NCT03677258
- Testing
- Collagen for injections 7%, Hyaluronic acid for injections 2%
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nearmedic Plus LLC
Breastfeeding, Self Efficacy
Design and Piloting of a Complex Intervention to Support Breastfeeding Self-efficacy (CRIAA Program)
The aim of the study is to design and pilot the effect of a complex intervention to support mothers' breastfeeding self-efficacy and professional self-efficacy to support breastfeeding families, considering breastfeeding as a…
- Trial name
- CRIAA (NCT03944642)
- Testing
- Breastfeeding support
- Where
- 4 sites in Chile, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile