Clinical trials: Complication of Infusion
Obstetric Labour, Premature
Study to Investigate the Pharmacokinetics (PK), Safety and Tolerability of Retosiban in Healthy Japanese Women
This study in healthy, adult Japanese women will characterize the PK, safety and tolerability of retosiban at the therapeutic doses planned to be evaluated in Phase 3.
- Trial name
- NCT02377414
- Testing
- Retosiban solution for Infusion
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Postoperative Pain
Postoperative Pain Therapy With Hydromorphone Using TCI-PCA
Treatment of postoperative pain with hydromorphone (a strong analgesic) using patient-controlled analgesia with target concentrations in blood compared to conventional patient-controlled analgesia after planed cardiac surgery
- Trial name
- TCI-PCA (NCT02035709)
- Testing
- Hydromorphone
- Where
- 2 sites in Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Bacteremia, Infant, Very Low Birth Weight
Preventing Catheter-related Bacteremia When Administering Injectable Medications in Premature Infants.
This study evaluates the potential interest of a new multi-lumen infusion access device (Edelvaiss® Multiline NEO) in the prevention of catheter-related bacteremia when administering injectable drugs in premature infants.
- Trial name
- MultilineNEO (NCT02633124)
- Testing
- Edelvaiss Multiline NEO, Standard Infusion Set
- Where
- 4 sites in France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Bispectral Index, Transcutaneous Carbon Dioxide
Compare the Side Effects and Difference Awake Level of Three TCI Propofol Formula in TVOR Patients
This study is to find the fewer side effects formula of anesthesia for TVOR patients, to compare the BIS level during emergence and to find the correlation between BIS and transcutaneous carbon dioxide concentration.
- Conditions
- Bispectral Index, Transcutaneous Carbon Dioxide, PONV, Blood Pressure
- Trial name
- NCT00760253
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Lidocaine, Dexmedetomidine
Effect of Lidocaine Plus Dexmedetomidine Infusion on PONV
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV).
- Conditions
- Lidocaine, Dexmedetomidine, Nausea and Vomiting, Postoperative
- Trial name
- NCT03788018
- Testing
- lidocaine and dexmedetomidine IV, saline IV
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xu Siqi
Blood Loss, Surgical, Postpartum Hemorrhage
Ideal Time of Oxytocin Infusion During Cesarean Section
This study will evaluate if the timing of oxytocin administration in cesarean deliveries will affect the amount of maternal blood loss.
- Conditions
- Blood Loss, Surgical, Postpartum Hemorrhage, Bleed Pregnancy, Pregnancy Related
- Trial name
- I-TOPICS (NCT03246919)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Loyola University
Ovarian Hyperstimulation Syndrome
The Effect of Human Albumin Infusion on VEGF Levels in Women at Risk for Ovarian Hyperstimulation Syndrome
This research study was designed to look at the effect of human albumin transfusion on circulating levels of Vascular Endothelial Derived Growth Factor (VEGF), a protein that is believed to be responsible for the syndrome of…
- Trial name
- NCT00617864
- Testing
- Human Albumin Infusion, Saline Infusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Peripheral Perfusion, Postoperative Pain
Effects Magnesium Sulfate and Labetalol Infusion on Peripheral Perfusion and Pain in Nasal Surgeries
One of main risk of controlled hypotension during nasal surgeries is impaired perfusion. Peripheral perfusion of non-vital organs usually impaired earlier than vital organs.
- Trial name
- NCT04688203
- Testing
- Magnesium Sulfate Injection, Labetalol Injectable Solution
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Post Operative Pain
Comparison of Intraoperative Intravenous Lidocaine Infusion and Transversus Abdominis Plane (TAP) Block for Post-operative Analgesia Following Laproscopic Cholecystectomy
This study is aimed to determine the post operative pain after laparoscopic cholecystectomy by dividing patients into three different group.
- Trial name
- NCT05231941
- Testing
- Lidocaine IV, Ropivacaine
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Renal Impairment
Pharmacokinetic, Pharmacodynamic and Tolerability Study of Otamixaban in Patients With Mild, Moderate and Severe Renal Impairment
Primary Objective: To study effect of mild, moderate and severe renal impairment on the pharmacokinetics of Otamixaban. Secondary Objective: To assess the pharmacodynamic effects of Otamixaban on subjects with mild, moderate and…
- Trial name
- NCT01120314
- Testing
- OTAMIXABAN (XRP0673)
- Where
- 4 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sanofi
Pain, Postoperative, Opioid Use
Therapeutic Efficacy of Intravenous Lidocaine Infusion Compared With Epidural Analgesia for Postoperative Pain Control in Adult Patients Undergoing Major Abdominal Surgery: Non-Inferiority Clinical Trial
Major abdominal surgery continues is one of the most performed surgical procedures in the world, both electively and urgently. One of the main problems of this type of intervention is postoperative pain.
- Trial name
- NCT04017013
- Testing
- Epidural Analgesia, Lidocaine Infusion
- Where
- Colombia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Hypoosmolality, Hyperosmolality
Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion
The are 2 principal goals in this study: 1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states. 2.
- Conditions
- Hypoosmolality, Hyperosmolality, Renal Failure
- Trial name
- NCT00696605
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Centre Biel/Bienne
Diabetic Foot Ulcer
The Therapeutical Role of Continuous Intra-femoral Artery Infusion of Urokinase on Diabetic Foot Ulcers
Diabetic foot ulcers (DFU) are one of the chronic consequences of diabetes which constitute the most important cause of non-traumatic amputation of the inferior limbs.
- Trial name
- NCT01108120
- Testing
- continuous intra-femoral thrombolysis group, Conventional therapy group
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Pelvic Pain, Endometriosis
Postoperative Narcotic Use After Laparoscopic Gynecologic Surgery
This will be a prospective, randomized, double blinded placebo-controlled study at Erlanger hospital. Eligible patients who provide consent will be randomized into one of two arms receiving continuous intra-peritoneal local…
- Conditions
- Pelvic Pain, Endometriosis, Pelvic Prolapse
- Trial name
- NCT04118777
- Testing
- Ropivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tennessee, Chattanooga
Postpartum Hemorrhage
Oxytocin Via Intramuscular Injection and Intravenous Bolus or Infusion for Prevention of Postpartum Hemorrhage
The study will evaluate whether prophylactic oxytocin administered in the third stage of labor via intravenous (IV) infusion or IV bolus reduces the rate of postpartum hemorrhage compared to intramuscular (IM) injection.
- Trial name
- NCT01914419
- Testing
- Oxytocin
- Where
- 2 sites in Egypt
- Volunteers
- 4,983 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
HIV Infections
A Study of Zidovudine in Infants Exposed to the HIV Before or Soon After Birth
To determine if intravenous (IV) and oral zidovudine (AZT) can be safely given to children aged 1 day to 3 months who were born to mothers with an HIV infection. Also to determine the correct dose of AZT for young children.
- Trial name
- NCT00001007
- Testing
- Zidovudine
- Where
- 6 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pain, Postoperative
Arthroscopic Anterior Cruciate Ligament Reconstruction: A Comparison of Three Catheter Placement Positions
This investigation will evaluate the subjective effect on postoperative pain of three catheter placements in the knee: 1. intraarticular infusion only, 2. patellar tendon harvest site only, 3.
- Trial name
- NCT00178178
- Testing
- Breg Pain Care 3000 Catheter, Bupivicaine 0.5%
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Postpartum Hemorrhage
Oxytocin Infusions and Blood Loss in Patients Undergoing Elective Cesarean Delivery.
Although prior dose-finding studies have investigated the optimal bolus dose of oxytocin to initiate adequate uterine tone, it is unclear what oxytocin infusion regimen is required to maintain adequate uterine tone after…
- Trial name
- NCT01932060
- Testing
- Oxytocin Infusion
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Stanford University
Renal Impairment
Pharmacokinetics and Safety of POL7080 in Patients With Renal Impairment
To investigate the pharmacokinetics (PK) of POL7080 in subjects with renal function impairment after single intravenous (IV) infusion of POL7080
- Trial name
- NCT02110459
- Testing
- POL7080
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Polyphor Ltd.