Clinical trials: Comprehension
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS
CAPTURE ALS is a long-term data and biorepository platform that will facilitate future ALS research. CAPTURE ALS will provide the standardized systems and tools necessary to collect, store, and analyze vast amounts of multimodal…
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy, Frontotemporal Degeneration
- Trial name
- CAPTURE ALS (NCT05204017)
- Where
- 4 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Healthy
A Study to Understand the Effect of a Study Medicine Called ARV-471 on Dabigatran Etexilate in Healthy Adults
The purpose of this study is to understand if ARV-471 affects how a medicine called, dabigatran etexilate, gets absorbed or processed into the body in healthy adults.
- Trial name
- NCT05673889
- Testing
- ARV-471, Dabigatran etexilate
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Influenza
Influenza Immunity in Children
This study evaluates how different methods of early exposure to influenza (natural infection, live attenuated influenza vaccination, inactivated influenza vaccination) initially stimulate immunity and poise the immune system to…
- Trial name
- NCT02559505
- Testing
- Seasonal IIV 0.25 mL dose, Natural influenza infection, Seasonal IIV 0.5 mL dose
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Educational Course
A Prospective Patient Education Program for IBD Patients
During the past few decades, key medical organizations have highlighted the importance of patient education and support. Evidence suggests that improving inflammatory bowel disease (IBD) patients' knowledge of their disease may…
- Trial name
- NCT05168345
- Testing
- Course and web information
- Where
- Israel
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Knowledge, Attitudes, Practice
The Effect of Pain Education on Multidisciplinary Healthcare Students' Understanding of Chronic Pain
Chronic pain is the leading cause of disability worldwide affecting just under 28 million people in the UK. Chronic pain conditions require a biopsychosocial rather than a biomedical model of care.
- Trial name
- NCT03710837
- Testing
- Pain neuroscience education, Red flag education
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Teesside University
Stress, Psychological Stress
Understanding Everyday Stress
This research study is being done to better understand how people experience stress in everyday life and how that stress may relate to sleep and physical activity.
- Trial name
- NCT05502575
- Testing
- Self-monitoring and personalized stress management, Self-monitoring and general stress management
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Penn State University
BRCA1-Related Hereditary Breast and Ovarian Cancer Syndrome, BRCA2-Related Hereditary Breast and Ovarian Cancer Syndrome
A Web-Based Program (Kindred) to Improve the Understanding of Genetic Cancer Risk and Cancer Genetic Testing in African American Families
This clinical trial studies whether a web-based program, Kindred, works to improve the understanding of genetic cancer risk and cancer genetic testing in African American families.
- Conditions
- BRCA1-Related Hereditary Breast and Ovarian Cancer Syndrome, BRCA2-Related Hereditary Breast and Ovarian Cancer Syndrome, Hereditary Neoplastic Syndrome, Lynch Syndrome
- Trial name
- NCT07542405
- Testing
- Discussion, Internet-Based Intervention, Survey Administration
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Pancreas Disease
Baby Formula and Health
The purpose of this study is to learn about how different types of carbohydrates used in infant formula may affect a baby's intestines and pancreas.
- Trial name
- NCT04559490
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Tuberculosis
Using BCG Vaccine to Understand Tuberculosis Infection
Tuberculosis (TB) is a disease that usually causes an infection in the lungs. The only vaccine to prevent TB is called BCG (Bacillus Calmette-Guérin).
- Trial name
- Pilot BCG CHIM (NCT05820594)
- Testing
- Intradermal BCG (bacillus calmette-guerin) vaccine AJV
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Lung Cancer Screening
Understanding Lung Cancer Related Risk Factors and Their Impact
LUCIA aims to develop prediction models for the early diagnosis of lung cancer based on the identification of risk factors and deeper cellular knowledge, by recording real-world data; with risk assessment tools, non-invasive…
- Trial name
- LUCIA (NCT06473870)
- Where
- 5 sites in Belgium, Latvia and 1 more
- Volunteers
- 6,160 people, healthy volunteers welcome
- Sponsor
- Biobizkaia Health Research Institute
Food Insecurity, Obesity, Childhood
Biobehavioral Mechanisms of Food Insecurity
Food insecurity is prevalent in the United States. Defined as unstable and inadequate access to food, food insecurity disproportionately affects low-income households, those with children and those with a Black or Hispanic head…
- Conditions
- Food Insecurity, Obesity, Childhood, Inflammation, Mental Health
- Trial name
- NCT04968496
- Testing
- Food Secure Group
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Development and Health, Behavior and Behavior Mechanisms
The Effect of Mobile Devices on the Development and Health of Young Children
Interactive electronic devices (IEDs) have become a common part of young children's lives, yet research on this topic remains limited.
- Conditions
- Development and Health, Behavior and Behavior Mechanisms, Cognition, Physical Health
- Trial name
- iKids (NCT06810570)
- Where
- 2 sites in United Kingdom
- Volunteers
- 874 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Stroke
Understanding Motor Function in Stroke Patients and Their Functional Brain Reorganization Using Ultra High-field MRI
The MOTIF-STROKE study is embedded within the BrainSync project, aiming to develop innovative strategies for motor rehabilitation of the upper limb.
- Trial name
- MOTIF-STROKE (NCT07339813)
- Testing
- Functional MRI (fMRI) Acquisition
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Commissariat A L'energie Atomique
COVID-19, SARS-CoV-2
Parent Study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA Sub-study)
AZD3152, a single mAb, is being developed to have broad neutralizing activity across known SARS-CoV-2 variants of concern for pre-exposure prophylaxis of COVID-19.
- Trial name
- SUPERNOVA (NCT05648110)
- Testing
- AZD5156 (Parent study Sentinel Safety Cohort), EVUSHELD™ (Parent study Main Cohort), AZD3152 (Parent study Main Cohort)
- Where
- 215 sites in United States, Australia and 16 more
- Volunteers
- 3,882 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity, Depression
Engaging Self-regulation Targets to Improve Mood and Weight and Understand Mechanism in Depressed and Obese Adults
Multimorbidity (i.e., the coexistence of 2 or more chronic conditions in an individual) is increasingly recognized as a pressing public health problem.
- Trial name
- NCT03841682
- Testing
- I-CARE2
- Where
- 2 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Health Literacy
Patient Understanding of Handouts at Different Reading Levels
The goal of this randomized clinical trial is to learn if participants are better able to understand medical handouts written at below a sixth grade reading level compared to those written at above a sixth grade reading level.
- Trial name
- NCT06736808
- Testing
- Handout Written at Below a Sixth Grade Reading Level, Handout Written at Above a Sixth Grade Reading Level
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Intermittent Fasting, Gut Microbiome
The Rufaida Project: Researching the Impact of Ramadan Fasting on the Gut and Vaginal Microbiome
The body's systems are deeply connected, but they are often studied separately. A recent large-scale citizen-science project on women's health, called Isala, discovered a group of gut-related bacteria present in the vaginal…
- Conditions
- Intermittent Fasting, Gut Microbiome, Vaginal Microbiome
- Trial name
- Rufaida (NCT07001358)
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Pelvic Organ Prolapse
Interactive Web-Based Tool for Pelvic Organ Prolapse: Impact on Patient Understanding and Provider Counseling
The primary aim is to assess whether an interactive patient/provider counseling process using a web-based tool (iPadTM) will improve patient satisfaction regarding understanding of her bulge symptoms.
- Trial name
- iPad (NCT01864408)
- Testing
- "Usual practice" counseling, Standard "usual practice" clinical counseling with the pelvic organ prolapse web-based tool (iPad).
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Knowledge, Attitude
Evaluating FDA's Proposed Patient Medication Information Handout
The goal of this study is to assess how useful the proposed one-page FDA-template PMI is to potential users. The main questions it aims to answer are: How does the proposed one-page FDA-template PMI compare with the current drug…
- Trial name
- NCT06320808
- Testing
- FDA template PMI, Decision Critical PMI, Standard Information
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Carnegie Mellon University
Tuberculosis Infection, Tuberculosis Prevention
Qualitative Understanding of Community TB Services Pre and Post the CHIP-TB Trial
This qualitative study is designed to elicit the perspectives of relevant stakeholders to adapt a community-based TB/HIV intervention aimed on providing home-based TB prevention treatment (TPT) initiation for child TB contacts…
- Trial name
- NCT04494516
- Where
- 2 sites in Ethiopia, South Africa
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University