Clinical trials: Comprehension, open to volunteers
Resistance, Thyroid Hormone
Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects
The goal of this observational study is to learn about the neurological and cardiological phenotype of patients with resistance to thyroid hormone (RTH) syndromes beta and alpha (RTHß and RTHa) due to dominant negative variants…
- Trial name
- ADAM-THAD (NCT06307990)
- Testing
- NGS sequencing, serological tests
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Depression, Anxiety Disorders
Understanding the Person, Exploring Change Across Psychotherapies
Identifying predictors and understanding mechanisms of change will inform referral to psychotherapy, triage and right-siting by helping clinicians to understand how their patients are likely to benefit from clinical…
- Trial name
- Xchange (NCT04106713)
- Testing
- Individual Psychotherapy, Internet-delivered Cognitive Behavioural Therapy (iCBT), Group Cognitive Behavioural Therapy (group CBT)
- Where
- Singapore
- Volunteers
- 250 people
- Sponsor
- Institute of Mental Health, Singapore
Cigarette Smoking-Related Carcinoma
Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and Maintenance
This study evaluates histories among cannabis and tobacco co-users of their initiation, escalation, and maintenance of the co-use behavior.
- Trial name
- NCT07439471
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Roswell Park Cancer Institute
Endometrial Carcinoma (EC), pMMR
IMMUNOTHERAPY EFFICACY TARGETING ENDOMETRIAL CANCER
Endometrial carcinoma (EC) represents the most common gynecological malignancy in developed countries. Despite therapeutic advances, patients with advanced or recurrent disease still have a poor prognosis, with high recurrence…
- Conditions
- Endometrial Carcinoma (EC), pMMR, DMMR Cancer
- Trial name
- DEMETER (NCT07374809)
- Testing
- DNA methylation profiles
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- European Institute of Oncology
Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma
Understanding New Cachexia Subtypes Through Observational Epidemiological Research
The UNCOVER study is a longitudinal observational cohort focused on patients at high risk for cancer cachexia. At Kaiser Permanente Northern California, up to 800 individuals with advanced or unresectable non-small cell lung…
- Conditions
- Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- UNCOVER (NCT07776353)
- Testing
- Biospecimen Collection, Computed Tomography, Electronic health record review
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Kaiser Permanente
Type2diabetes, Heart Failure
Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure
This study aims to determine whether a 6-month multilevel intervention involving problem-solving training, exercise training and support from community health workers is more effective in improving outcomes for individuals with…
- Conditions
- Type2diabetes, Heart Failure, Obesity
- Trial name
- UNLOAD-HF (NCT06364644)
- Testing
- Community Champions, Homegrown Heroes
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Johns Hopkins University
Cancer, CUP
Living Without Answers - ILLUMINATE CUP
This project aims to improve care, service delivery, and patient experience for people with Cancer of Unknown Primary (CUP) by addressing a critical gap in understanding the lived experiences of patients and carers.
- Conditions
- Cancer, CUP, Cancer Unknown Primary
- Trial name
- ILLUMINATE CUP (NCT07712965)
- Volunteers
- 20 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
Corticospinal Excitability, Cortical Activation
LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research.
- Trial name
- LAMI (NCT06478303)
- Testing
- Motor imagery, Action reading, Motor localizer
- Where
- 2 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Math Learning Disability
Understanding Cognitive-Academic Bidirectionality in Math Learning Disabilities
The goal of this clinical trial is to test the effects of an innovative intervention designed to improve math skills in first graders at risk for math disabilities.
- Trial name
- NCT07220746
- Testing
- Coordinated Treatment, Math Treatment
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University
Autism Spectrum Disorder, Schizophrenia Disorder
Understanding and Treating Severe and Resistant Pathological Aggression: Using Deep Brain Stimulation to Treat Resistant Aggression
Physical aggression can be defined as the use of force with the intention of causing physical injury, psychological damage or death. Pathological aggression may be associated with various psychiatric disorders.
- Trial name
- STAR (NCT07315685)
- Testing
- neurostimulator
- Where
- 2 sites in France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Rouen
Tobacco-Related Carcinoma
THRIVE Study: Understanding How Oral Nicotine Pouches Affect Public Health
Although nicotine pouches have been gaining popularity over the last few years, little known about how nicotine pouch users actually use these products. This study will be comprised of adults who use nicotine pouches.
- Trial name
- THRIVE (NCT07503925)
- Testing
- Biospecimen Collection, Nicotine Oral Pouch, Survey Administration
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Vaginoplasty, Gender Dysphoria, Adult
Can 3D Modeling Enhance Patient Understanding, Education, and Surgical Outcomes in Gender Affirming Peritoneal Vaginoplasty?
The project aims to address both clinical and relational gaps in transgender surgical care by improving understanding, communication, and outcomes through this novel integration of personalized 3D technology.
- Trial name
- 3D Modeling (NCT07412509)
- Testing
- Use 3D printed patient specific models for patient education
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
No Condition
Understanding How Peer Support Helps in Mental Health Care
The goal of this observational study is to better understand the psychological processes associated with professional peer support among adults using psychiatric services.
- Trial name
- PAIR-PROS (NCT07849621)
- Testing
- Perceptions of professional peer support and mental health professional support
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University of Bordeaux
Traumatic Brain Injury
Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)
The purpose of this research is to understand and treat Traumatic Brain Injury (TBI) associated photophobia (light sensitivity) and its impact on visual function.
- Trial name
- NCT06293300
- Testing
- BoNT A
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
High Blood Sugar, High Blood Pressure
Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study
Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides.
- Conditions
- High Blood Sugar, High Blood Pressure, Overweight and Obesity
- Trial name
- NCT06555393
- Testing
- Egg White Powder
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cardiovascular Diseases, Myocardial Ischemia
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural…
- Conditions
- Cardiovascular Diseases, Myocardial Ischemia, Heart Diseases, Arteriosclerosis
- Trial name
- NCT07286578
- Testing
- CT(Computed Tomography) guided Percutaneous Coronary Intervention, IVUS (Intravascular Ultrasound) guided Percutaneous Coronary Intervention
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 700 people
- Sponsor
- Fundación EPIC
Sensorineural Hearing Loss, Bilateral
Comparison of Speech Understanding Between Tonotopy-based Fitting and Setting Based on Evolutionary Algorithms
Main objective: Compare speech recognition in noise with tonotopic setting (FS4T) and with tonotopic fitting modified by evolutionary algorithm (EAFS4T) in adult patients implanted for 6 months or more with a MED-EL cochlear…
- Trial name
- NCT06737185
- Testing
- EAFS4T: modification with evolutionary algorithm of tonotopic-based fitting
- Where
- France
- Volunteers
- 22 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Bulimia Nervosa, Feeding and Eating Disorders
Understanding and Targeting Self-Regulatory Control in Bulimia Nervosa
The purpose of this study is to examine the effects of noninvasive prefrontal cortex (PFC) neurofeedback during eating in women with bulimia nervosa (BN) using wearable brain imaging, functional near-infrared spectroscopy…
- Conditions
- Bulimia Nervosa, Feeding and Eating Disorders, Mental Disorders
- Trial name
- NCT07581158
- Testing
- Real fNIRS Neurofeedback, SmartPhone Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Heart Failure, Heart Failure - NYHA II - IV
Ted Rogers Understanding of Exacerbations in Heart Failure 2: Monitor
Heart Failure (HF) is a complex disease associated with the highest burden of cost to the healthcare system. The cardiopulmonary exercise test (CPET) is instrumental in determining the prognosis of patients with HF.
- Conditions
- Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Patients, Cardiopulmonary Exercise Test
- Trial name
- TRUE-HF 2 (NCT07447908)
- Where
- 3 sites in Canada
- Volunteers
- 360 people
- Sponsor
- University Health Network, Toronto
Infant Development
Babies' Brain Responses to Strangers
Researchers at the Diversity in Development Lab at UC Santa Cruz are investigating how babies' brain activities respond to people from familiar and unfamiliar racial backgrounds.
- Trial name
- NCT06550245
- Testing
- Infants observing familiar and unfamiliar racial groups
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California Santa Cruz