Clinical trials: Computed Tomography Scan
Osteoporosis, Sarcopenia
Bone Microstructure by Using HR-pQCT After Esophagectomy
Esophagectomy is most curative treatment to esophageal cancer. However, osteoporosis , which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course…
- Conditions
- Osteoporosis, Sarcopenia, Esophageal Cancer
- Trial name
- NCT05812235
- Testing
- esophagectomy
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Nagasaki University
Knee Arthroplasty, Total, Healthy Participants
Proof of Concept for Simulating Static Weight-bearing Exercises in the Supine Position
This project evaluates a new weight-bearing CT method to later improve early detection of implant migration after knee arthroplasty.
- Trial name
- SWB_PoC (NCT07572292)
- Testing
- Static supine weight bearing CT
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Lung Cancer, Lung Cancer Screening
Assessing the Effectiveness of Low-Dose Computed Tomography in Lung Cancer Screening for High-Risk Smokers: A Randomized Controlled Trial in Hong Kong
The investigators propose a randomized controlled trial to evaluate the clinical effectiveness of low-dose computed tomography (LDCT) for lung cancer screening in high-risk Chinese ever-smokers aged 50-79 years in Hong Kong and…
- Trial name
- NCT07478757
- Testing
- Low-dose computed tomography (LDCT)
- Where
- Hong Kong
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Obstructive Sleep Apnea Syndrome
Clinical Study of Customized Adjustable Oral in Treatment of Patients With Obstructive Sleep Apnea Syndrome
The oral appliances (OAs) are considered to be an effective treatment modality for snoring and various forms of obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT03729895
- Testing
- Adjustable Oral Appliance
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Healthy Volunteers Only
A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults
This study investigates how body fat distribution affects airway closure and lung mechanics in healthy adults. Using Electrical Impedance Tomography (EIT), esophageal manometry, and computed tomography (CT), we aim to…
- Trial name
- NCT07019831
- Testing
- Body positioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maurizio F. Cereda, MD
Coronary Artery Disease, Atherosclerosis
Biomarkers and Cardiac CT
Coronary artery disease (CAD) is the leading cause of morbidity and mortality in developed countries. In addition, many patients suffer from valvular and aortic disease.
- Trial name
- NCT02381301
- Testing
- Venous blood sampling prior to CCTA.
- Where
- Netherlands
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Patellofemoral Joint
Use of a Novel Weight Bearing Cone Beam Computed Tomography (CBCT) Scanner for Imaging of the Patellofemoral Joint
Healthy volunteers will have a weight bearing cone beam CT scan of their knee to assess normal alignment of the knee joint
- Trial name
- NPF (NCT02762630)
- Testing
- Carestream Health Inc. weight bearing cone beam CT scanner
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Healthy
A Phase 1, Open-Label, Single-photon Emission Computed Tomography (SPECT) Study to Evaluate Serotonin and Dopamine Transporter Occupancy After Multiple Dose Administration of SEP-228432 to Achieve Steady State in Healthy Subjects
This is an open-label study investigating the relationship between SEP-228432 and SEP-228431 (the active metabolite of SEP-228432) plasma concentrations, SERT occupancy, and DAT occupancy, both measured by SPECT imaging.
- Trial name
- NCT01531972
- Testing
- SEP-228432
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sumitomo Pharma America, Inc.
Coronary Artery Disease of Significant Bypass Graft, Coronary Syndrome
Implementation of Contemporary Coronary CT Angiography in Clinical Practice
Coronary CT angiography (CCTA) has been recognized as the first-line diagnostic test for most patients with suspected coronary syndrome, often acting as a gatekeeper for invasive coronary angiography.
- Conditions
- Coronary Artery Disease of Significant Bypass Graft, Coronary Syndrome, Coronary Arteriosclerosis
- Trial name
- CONCORDE (NCT06273033)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Humanitas Hospital, Italy
Chronic Kidney Disease Mineral and Bone Disorder
Calcium Balance Studies in Children With CKD and on Dialysis
This is a novel, non-invasive method of assessing Ca balance by natural Ca isotope fractionation.
- Trial name
- Cal-Bal (NCT03285854)
- Testing
- Collection of blood, urine and stool samples
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Healthy Volunteers
Single Dose Safety, Tolerability and Pharmacokinetic Study of NCTX in Healthy Volunteers
This is a randomized, double-blind, single dose, dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of NCTX (PEGylated Liposomal Iodixanol Injection) administered intravenously to healthy volunteers.
- Trial name
- NCT02063594
- Testing
- NCTX (PEGylated Liposomal Iodixanol Injection)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marval Pharma Ltd.
Parkinsonian Syndrome, Parkinson Disease(PD)
A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients
This is a multicenter, open-label, non-controlled, non-randomized, phase 3 clinical study to compare the SPECT findings after a single IV administration of DaTSCAN™ ioflupane (123I) injection for patients with a clinical…
- Conditions
- Parkinsonian Syndrome, Parkinson Disease(PD), Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP)
- Trial name
- NCT04193527
- Testing
- DaTSCAN™ Ioflupane (123I) Injection
- Where
- 10 sites in China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Obesity
Cerebral Blood Flow Changes in People With Obesity After Glucose Consumption
This study evaluates the hypothesis that a meal constituted of only glucose produces differences in the brain blood flow in people with obesity that are not observed in people without obesity.
- Trial name
- NCT02072694
- Testing
- 75 grams of glucose plus water solution, Pure water
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Breast Cancer
Opportunistic Breast Cancer Screening Using Non-Contrast Chest CT
The goal of this observational study is to evaluate the feasibility and effectiveness of using non-contrast chest computed tomography scans for opportunistic breast cancer screening, and to further compare its diagnostic…
- Trial name
- OPBCS-CT (NCT07557654)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Visceral Obesity, Atherosclerosis
Abdominal Fat and Imaging Measurements of Heart Disease
Although it is frequently mentioned in the media that overweight and obesity have reached epidemic proportions worldwide and in this country, some Canadians are perplexed and sometimes confused about the role of obesity in…
- Conditions
- Visceral Obesity, Atherosclerosis, Metabolic Syndrome
- Trial name
- NCT01447745
- Where
- Canada
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Laval University
Immediate Implant Placement
Socket Evaluation System to Predict Labial Bone Formation Around Immediate Implants. A Retrospective Cone Beam Computed Tomography Analysis.
Palate implant placement in extraction sockets, with a minimum of 2 mm between the implant and the inner side of the facial socket wall, has been advised as a step towards a 3D restorative-driven posture.
- Trial name
- NCT06246253
- Testing
- Virtual implant placement following safe angle concept, actual implant placement following safe angle concept
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Misr International University
Lung Cancer, Cardiovascular Disease (CVD)
Optimised Lung Cancer Screening to Prevent Cardiovascular and Pulmonary Diseases Coupled With Primary Prevention
This project aims to implement a health prevention program for smokers or former smokers including early detection of lung cancer, cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD).
- Conditions
- Lung Cancer, Cardiovascular Disease (CVD), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SMAC-1 (NCT04315766)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Lung Cancer
LDCT Screening in Non-smokers in Taiwan
This study utilizes the low dose computed tomography(LDCT) to detect the occurrence of early lung cancer among non-smokers in Taiwan.
- Trial name
- NCT02611570
- Testing
- LDCT
- Where
- 17 sites in Taiwan
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Academia Sinica, Taiwan
Aortic Valve Stenosis
Metabolic Determinants of the Progression of Aortic Stenosis
Calcific aortic stenosis (AS) has become the most common cardiac disease after coronary artery disease and hypertension. Unfortunately no medical therapies have been proven to decrease either the progression of valve stenosis or…
- Trial name
- PROGRESSA (NCT01679431)
- Testing
- Doppler-echocardiography, Computed tomography, Magnetic resonance imaging
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Laval University
Periodontal Diseases
Comparison of the Effectiveness of the USG and CBCT Combined With Intraoral Scanning Determing the Gingival Phenotype in the Healthy Periodontium
Compare two diagnostic methods: UGTM and CBCT/CAD/PDIP in determing the gingival phenotype in group of 30 periodontally healthy patients.
- Trial name
- NCT04845581
- Testing
- Diagnostic tests: Determination of the gingival phenotype, measure gingival thickness and width of keratinized tissue
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University