Clinical trials: Concussion, Mild Traumatic Brain Injury
Traumatic Brain Injury, Insomnia
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and…
- Conditions
- Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress
- Trial name
- NCT05663034
- Testing
- Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
- Where
- 5 sites in United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Concussion, Mild
Early Sub-threshold Exercise Treatment for Concussion
Each year millions of Americans suffer concussions as a result of accidents in sports, at work or through military service. Adolescents take the longest to recover from the effects of concussion yet no therapy exists to help…
- Trial name
- NCT03569709
- Testing
- Aerobic Exercise, Rest, Stretching
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Mild Traumatic Brain Injury
Sensorimotor Stimulation, Routine Physical Therapy, Balance, Cognitive Performance Mild Traumatic Brain Injury Patients
Study design: Randomized controlled trial Settings: Physiotherapy department of Allied hospital, Faisalabad Sample size: 27 in each group Control group receive: Routine physical therapy Experimental group receive: Routine…
- Trial name
- NCT05194644
- Testing
- Routine physical therapy+ Sensorimotor stimulation, Routine physical therapy
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- University of Lahore
Concussion, Mild, Traumatic Brain Injury, Mild
Mag Con: Efficacy of Oral Mag. in Acute Concussion in Adolescents
This randomized trial will compare the clinical efficacy of adding oral magnesium oxide to acetaminophen and ondansetron in the treatment of adolescents presenting within 48 hours of a mild traumatic brain injury using the…
- Trial name
- NCT05065528
- Testing
- Magnesium
- Where
- United States
- Sponsor
- Corewell Health South
Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury
Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms
This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals…
- Trial name
- NCT07246993
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Concussion, Mild, Rehabilitation
The Effect of a Sub-symptom Threshold Aerobic Exercise Program on Recovery in Concussed Athletes
The purpose of this randomized controlled trial is to examine whether systematic sub-threshold exercise is effective in improving recovery time in athletes after sport related concussion (SRC) compared to those who participate in…
- Trial name
- NCT03865433
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rocky Mountain University of Health Professions
Concussion, Mild
Predicting Concussion Outcomes With Salivary miRNA
The purpose of this study is to identify changes in salivary ribosomal nucleic acid (RNA) expression that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.
- Trial name
- NCT02901821
- Testing
- salivary RNA collection
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI)
Memantine as an Additive Therapy in Patients With Traumatic Brain Injury
Memantine has shown promise in mitigating secondary brain injury in previous studies. One study demonstrated that early memantine administration in moderate TBI patients resulted in lower serum neuron-specific enolase levels and…
- Trial name
- NCT06914310
- Testing
- Memantine, Mannitol
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Concussion, Mild, Concussion, Intermediate
Assessment of the Effects of Concussion on Adolescent Rugby Union Players
200 adolescent rugby players (aged 15-19) from the Senior Cup Teams of 5 Rugby Playing schools (Members of Irish Schools Rugby) will be invited to enroll for inclusion in the study.
- Conditions
- Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- NCT03624634
- Where
- Ireland
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Sports Surgery Clinic, Santry, Dublin
Mild Traumatic Brain Injury
The Use of the VOMS Tool With Military Personnel to Track mTBI Recovery and RTD Status
The purpose of the proposed project is to determine if the VOMS is an effective screening tool to identify and track recovery of vestibular and ocular motor impairment and symptoms following mTBI, that corpsman-level medical…
- Trial name
- NCT02634944
- Testing
- Vestibular Ocular Motor Screening Tool (VOMS)
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Mild Traumatic Brain Injury, Concussion, Rehabilitation
Wearable Technology to Characterize and Treat mTBI Subtypes: Biofeedback-Based Precision Rehabilitation
Current clinical assessment tools are often not sensitive enough to detect and treat some subtle (yet troubling) problems after mTBI.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Rehabilitation, Balance Impairment
- Trial name
- SuBTyPE (NCT06381674)
- Testing
- Vestibular therapy for mTBI augmented with audio and visual real-time biofeedback, Vestibular therapy for mTBI
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Concussion, Mild
Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes
Can nicotinamide riboside (750 mg/day for 12 weeks) affect the levels of NAD+ in the brain as measured by 31P MRS?
- Trial name
- TRMC-004 (NCT02721537)
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Concussion, Brain, Mild Traumatic Brain Injury
Risk Stratification in Children With Concussion
This project will measure concussion symptoms, biological markers, and academic and social factors across the first year postconcussion to develop a model that enables early identification of and symptom management for children…
- Trial name
- RSiCC (NCT05825027)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Concussion, Mild Traumatic Brain Injury
Cognitive-Communication Screening and Early Therapy for Adults With Mild TBI
Approximately 15-20% of patients diagnosed with a concussion/mild traumatic brain injury (mTBI) have persistent symptoms that continue up to six months or longer.
- Conditions
- Concussion, Mild Traumatic Brain Injury, Cognitive Communication Disorder
- Trial name
- NCT03230656
- Testing
- Early cognitive-communication therapy
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Northern Arizona University
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Injuries, Head, Traumatic Brain Injuries
Point of Care Testing in Emergency Departments After Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is estimated to have the highest incidence of all common neurological disorders, affecting 50 to 60 million people worldwide each year.
- Trial name
- POCkET (NCT07129577)
- Volunteers
- 400 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Mild Traumatic Brain Injury
Behavioral Profile Matching: A Precision Medicine Approach to Concussion Rehabilitation
At least 1 in 5 people who sustain a concussion will have persistent symptoms and difficulties with daily activities. The researchers have identified two unhelpful coping styles following a concussion - avoidance and endurance.
- Trial name
- NCT03972579
- Testing
- Graded exposure therapy, Pacing + mindfulness
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Mild Traumatic Brain Injury
SSVEP Evaluation of Brain Function
The investigational device used in this clinical investigation, the Nurochek Headset, is a portable electroencephalogram (EEG) headset which delivers a visual stimulus and measures a VEP.
- Trial name
- NCT05614570
- Testing
- SSVEP Device, SCAT5
- Where
- Australia
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Headsafe MFG
Dementia
Prazosin and Cerebrospinal Fluid (CSF) Biomarkers in Mild Traumatic Brain Injury (mTBI)
Mild traumatic brain injury (mTBI) from explosions is the "signature injury" of Veterans who have deployed to the wars in Afghanistan and Iraq.
- Trial name
- PoND (NCT03221751)
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine