Clinical trials: Concussion
Concussion, Brain
Development of a Concussion Management Platform for Children and Youth
This multi-centred, randomized controlled trial will evaluate the effectiveness of a pilot tested mobile device Application built to guide youth in recovery from concussion.
- Trial name
- Back2PlayApp (NCT05471791)
- Testing
- Back2Play App
- Where
- 2 sites in Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- McMaster University
Brain Concussion
The s100β Levels in Patients With Mild Brain Injury.
Mild traumatic brain injury (TBI) accounts for the majority of TBI. At present, whether TBI has traumatic intracranial lession is mainly diagnosed by computed tomography (CT), while only 5% of mild TBI has positive CT results.
- Trial name
- NCT06131242
- Testing
- It is an observational study
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Sumei Lu
Mild Traumatic Brain Injury
HEAD Injury Serum Markers and Multi-modalities for Assessing Response to Trauma
The goal of HeadSMART II (HEAD injury Serum markers and Multi-modalities for Assessing Response to Trauma II) is to develop an In-Vitro Diagnostic, the BRAINBox TBI test, to aid in the diagnosis and prognosis of patients with…
- Trial name
- HeadSMART II (NCT04423198)
- Testing
- Cognitive Assessment, Patient Reported Neurological Outcome Assessments, Blood Draw
- Where
- 11 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- BRAINBox Solutions Inc
Sport Related Concussion
Pilot Study on the Correlation Between Accelerations Experienced
Concussion, or mild traumatic brain injury, accounts for 85% of brain injuries and is common in both professional and amateur sports.
- Trial name
- BIOIMPACT (NCT07507253)
- Testing
- Analyze correlations between the measurements of the variations in biomarkers with those obtained by an instrumented mouthguard measuring accelerations.
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sys2Diag
Concussion, Brain
Comparing and Interactive Concussion Education Platform to Current Education Standards
Purpose: The purpose of this study is to evaluate the effectiveness of a theory- driven education platform to improve concussion-related norms and perceptions in an effort to improve student-athletes concussion-related…
- Trial name
- NCT04122274
- Testing
- NCAA education sheet, Decision-based interactive concussive education platform
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Concussion, Brain, Mild Traumatic Brain Injury
The Effects of Environmental Distractions on SCAT6 Outcomes
The purpose of this study is to assess the effects of visual and auditory distractions on SCAT5 scores. The study is designed to identify the effects of about 80 participants completing the SCAT5 in college-aged athletes.
- Trial name
- NCT05886400
- Testing
- SCAT6, Visual/ Auditory Distraction
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Indiana University
Brain Concussion, Reflex, Pupillary
Utility of Pupillary Metrics in Diagnosis and Management of Concussion in Children
The purpose of this study is to gather information and compare the potential use of pupillometry to identify concussions and post concussive syndrome with standard age appropriate assessments.
- Conditions
- Brain Concussion, Reflex, Pupillary, Post-Concussion Syndrome, Brain Injuries, Traumatic
- Trial name
- NCT04540445
- Testing
- Pupillary Assessment
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Head Injury, Face
Craneofacial Injuries in Rink Hockey Athletes
To collect the number of injuries that affect the face and head in rink hockey athletes prospectively during a regular season.
- Conditions
- Head Injury, Face, Concussion, Brain
- Trial name
- NCT05400551
- Where
- 2 sites in Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury
BCAAs in Concussion 3.0
This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion.
- Conditions
- Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury, Concussion, Brain, Concussion
- Trial name
- NCT07670195
- Testing
- BCAA
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Akiva Cohen
Mild Traumatic Brain Injury
The Use of Anti-oxidants to Reduce Sequela of Mild Traumatic Brain Injury (mTBI) After Blast Exposure
The administration of N-acetyl-cysteine (an anti-oxidant) for seven days along with observation will result in improved hearing and balance function in individuals who demonstrate these disorders after blast exposure when…
- Trial name
- NCT00822263
- Testing
- N-acetyl-cysteine (NAC)
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Mild Traumatic Brain Injury, Acute Brain Injury
Aerobic Exercise for Concussion
The use of aerobic exercise treatment in the chronic phase of concussion recovery is well-described in the literature but there are limited existing data on the effect of exercise treatment in the acute phase after sport-related…
- Conditions
- Mild Traumatic Brain Injury, Acute Brain Injury, Brain Concussion
- Trial name
- NCT02959216
- Testing
- Aerobic Exercise, Stretching Exercise
- Where
- 3 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Concussion, Brain
Role of Rehabilitation in Concussion Management: A Randomized Controlled Trial
Approximately 420 professional and amateur athletes will participate in rehabilitation during recovery after sports-related concussion. Participants will be cluster randomized, by study site, to a specific study arm.
- Trial name
- NCT02988596
- Testing
- Multidimensional Active Rehabilitation, Enhanced Graded Exertion
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Concussion, Mild
Non-invasive Brain Stimulation and Injury Risk Biomechanics
The goal of this clinical trial is to test the effects of repetitive transcranial magnetic stimulation (theta burst stimulation) on movement biomechanics (jump landing) among individuals with and without a concussion history.
- Trial name
- NCT06093295
- Testing
- Repetitive Transcranial Magnetic Stimulation (Theta Burst Stimulation)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Post Concussive Syndrome
An fMRI Study of Attention and Effort After Concussion
Approximately 1.1 million people a year suffer a mild traumatic brain injury (MTBI), or concussion, in the United States. Although most MTBI patients fully recover, as many as 28% have physical, cognitive, and/or emotional…
- Trial name
- NCT00653029
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Mild Traumatic Brain Injury
Advanced Imaging Tools in the Study of Mild Traumatic Brain Injury
We will utilize a set of imaging modalities including computed tomography (CT), positron emission tomography (PET), and a suite of magnetic resonance imaging (MRI) tools, to investigate the changes in the human brain resulting…
- Trial name
- mTBI (NCT01044615)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kettering Health Network
Eye-tracking
EYE-TRAC Advance: Technology Verification (ETA-TV) Cohort 1
This study will assess the effects of exercise and non-concussive bodily contact on eye-tracking scores collected by the EYE-SYNC eye-tracking device.
- Trial name
- ETA-TV (NCT02844543)
- Testing
- EYE-SYNC eye-tracking device, SCAT-3, Desktop Eye-Tracker
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Stanford University
Head Injury, Sport Injury
Dynamic Vision Testing and Concussion Management
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol.
- Conditions
- Head Injury, Sport Injury, Concussion, Brain
- Trial name
- NCT04837066
- Testing
- Dynamic Vision Testing (Bertec Vision Advantage System) and Balance Error Scoring System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Concussion, Mild
Impact of Instability Training on Vestibular Dysfunction in Postconcussion Combat Athletes
We are conducting RCT study on concussion on combat sports athlete and there is high incidence of on concussion in this sports and we will find the association between concussion and vestibular impairment and then we will apply…
- Trial name
- NCT07729761
- Testing
- Traditional Physical therapy, Instability training
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Anterior Cruciate Ligament Injuries, Concussion, Brain
Making Football Safer for Women: Implementing an Injury Prevention Program
The aim of this study is to determine how we can best support coaches to implement an injury prevention (IP) program (Prep-to-Play) in female community Australian Football.
- Conditions
- Anterior Cruciate Ligament Injuries, Concussion, Brain, Musculoskeletal Injury
- Trial name
- Prep-to-Play (NCT04856241)
- Testing
- Coaching, Peer support, Educational materials
- Where
- Australia
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- La Trobe University
Concussion
Driving Performance of Teenage Patients With mTBI: a Longitudinal Assessment
This study will synthesize a behavioral profile of impaired driving performance for teenage patients with mild traumatic brain injury (mTBI), or concussion, from one week post-concussion to six weeks post-concussion.
- Trial name
- NCT02278029
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati