Clinical trials: Controlled Diabetes
Diabetic Foot Ulcer
Plantar Pressure Distribution in Diabetic Foot Ulcer
The goal of this clinical trial is to find out the changes in peak pressure and pressure-time integral after twelve weeks from the initial utility of foot insoles and eight weeks later as a follow-up in diabetic foot ulcers.
- Trial name
- PPDDFU (NCT05888259)
- Testing
- foot insole
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Autonomic Dysfunction, Stress, Psychological
The SongDanceT1 Study: Stress, Ongoing Self- Monitoring and Diabetes, Nerve Stimulation and Cognitive Empowerment.
In an implementation study, designed as a RCT in people with type 1 diabetes(T1D) and an elevated Pressure pain sensitivity of the chest bone(PPS) as indicative of dysfunction of the autonomic nervous system (ANSD), to describe…
- Trial name
- SongDanceT1 (NCT06087679)
- Testing
- PPS guided selfcare based intervention program
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes
Low Glycemic Index Diets (With Pulses) in Type 2 Diabetes
Healthy individuals with type 2 diabetes will receive intensive counseling on food selection to improve glucose control using either high cereal fiber dietary strategies or low glycemic index foods emphasizing dried legumes and…
- Trial name
- NCT01063361
- Testing
- Low glycemic index diet with pulses, High Cereal Fibre
- Where
- Canada
- Volunteers
- 131 people
- Sponsor
- University of Toronto
Non-Insulin-Dependent Diabetes Mellitus
Study In Patients With Type 2 Diabetes Who Are Taking Metformin And Sulfonylurea, Metformin And Insulin, Or Insulin
This study will use Magnetic Resonance Imaging (MRI) techniques to evaluate changes in fluid volume in the lower legs of diabetic patients who add either pioglitazone or placebo to their current diabetic regimen.
- Trial name
- NCT00269061
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Type 1 Diabetes Mellitus
Artificial Pancreas Control System in an Outpatient Setting
The objectives of this outpatient research study are (1) to assess the ability of this automated system to be operated by a subject with limited professional oversight; (2) to assess whether the new devices (Dexcom Gen 4 sensors…
- Trial name
- NCT01871870
- Testing
- Artificial Pancreas Control Software
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Legacy Health System
Type 2 Diabetes Mellitus
Assessment of Gastric Emptying by SHR20004 in Healthy Subjects
The purpose of this study is to investigate the impact of SHR20004 on the pharmacokinetic (PK) characteristics of acetaminophen in healthy subjects.
- Trial name
- NCT06137469
- Testing
- Acetaminophen/SHR20004
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Diabetic Foot Ulcer, Diabetic Foot
A Unique Micro Water Jet Technology Device Versus Standard Debridement in the Treatment of Diabetic Foot
The purpose of this clinical investigation is to assess performance of the Medaxis Debritom+™ and to collect subject outcome data in the treatment of diabetic foot ulcers (DFU) vs Standard sharp debridement.
- Trial name
- NCT04564443
- Testing
- Medaxis Debritom+, Sharp Surgical Debridement, Additional Outer Dressing Application
- Where
- 6 sites in United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Medaxis, LLC
Diabetes Mellitus
ELO Water In Diabetes Care For Enhancement Of Blood Sugar Control
This double-blinded, randomised and controlled trial evaluates the efficacy of oxygen-enriched ELO drinking water as an adjuvant modality in diabetes care for enhancement of glycemic control in patients with Type 2 diabetes…
- Trial name
- EDEN (NCT04127890)
- Testing
- ELO Water
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- Changi General Hospital
Atherosclerosis, Cardiovascular Disease
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
To evaluate the safety, tolerability, PK and immunogenicity of single and multiple ascending doses of MEDI6570 in subjects with Type 2 Diabetes Mellitus
- Trial name
- NCT03654313
- Testing
- MEDI6570
- Where
- 9 sites in United States
- Volunteers
- 88 people
- Sponsor
- MedImmune LLC
Diabetes Mellitus, Type 2
Efficacy of an Electronic System to Support Clinical Decisions in Adults With Type 2 Diabetes Mellitus.
To assess the efficacy of an electronic system to support clinical decisions based on an evidence-based clinical practice guide for metabolic control of adults with Type 2 Diabetes Mellitus through Clinical and cluster-randomized…
- Trial name
- OSI-DM (NCT03160196)
- Testing
- Clinical Decision Support System, Usual care based on clinical practice guideline
- Volunteers
- 1,768 people
- Sponsor
- Sanitas University
Type 2 Diabetes
Effects of Nasulin Versus Placebo on Blood Glucose Control in Patient Volunteers With Type 2 Diabetes Mellitus
The purpose of this study is: To assess the efficacy of Nasulin vs. placebo as indicated by time spent in euglycemia, assessed by continuous glucose monitoring data and serum fructosamine levels in patient volunteers with Type 2…
- Trial name
- CPEX-011 (NCT00850096)
- Testing
- Nasulin
- Where
- 21 sites in United States
- Volunteers
- 94 people
- Sponsor
- CPEX Pharmaceuticals Inc.
Type 2 Diabetes Mellitus
Phase III Trial to Evaluate the Efficacy and Safety of Initial Combination Therapy With Gemigliptin 50mg q.d and Metformin q.d
The objective of this study is to evaluate efficacy and safety of initial combination therapy with Gemigliptin 50mg q.d and Metformin q.d compared with either monotherapy in treatment naïve patients with type 2 diabetes, In other…
- Trial name
- NCT01787396
- Testing
- Gemigliptin 50mg, Metformin
- Where
- South Korea
- Volunteers
- 433 people
- Sponsor
- LG Life Sciences
Type 1 Diabetes Mellitus, Hypoglycemia
24/7 Closed-loop in Older Subjects With Type 1 Diabetes
The main objective of this open-label, multi-centre, randomised, crossover design study is to determine whether automated day and night closed-loop insulin delivery for 16 weeks under free living conditions is safer and more…
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Arrythmia
- Trial name
- DAN06 (NCT04025762)
- Testing
- Hybrid closed-loop system (CamAPS FX), Sensor augmented pump therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- University of Cambridge
Obesity
Reward Mechanisms in Obesity
The study aims to investigate the effects of 3.0 mg of liraglutide on reward brain circuits in human obesity and to better understand its effects on weight loss (in patients without diabetes).
- Trial name
- LIRAOB (NCT03347890)
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zoltan Pataky
Diabetes Mellitus Type 2
Effects of Empagliflozin + Linagliptin vs Metformin + Insulin Glargine on Renal and Vascular Changes in Type 2 Diabetes
Diabetes mellitus is a wide-spread disease accompanied by strongly increased morbidity and mortality due to micro- and macrovascular complications.
- Trial name
- ELMI (NCT02752113)
- Testing
- Empagliflozin and Linagliptin, Metformin and Insulin sc
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Pain, Chronic Pain
A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care
The purpose of this study is to evaluate the impact of genetic testing on healthcare decisions and patient outcomes for patients suffering from pain, cardiovascular problems, Arthritis, Type II Diabetes, and/or Mental Health…
- Conditions
- Pain, Chronic Pain, Mental Disorders, Cardiovascular Diseases
- Trial name
- REVOLUTION (NCT02487888)
- Testing
- Unblinded to Genetic Testing Results, Blinded to Genetic Testing Results
- Where
- 31 sites in United States
- Volunteers
- 100,000 people
- Sponsor
- Proove Bioscience, Inc.
Type 2 Diabetes
A Trial Comparing Efficacy and Safety of GZR101 and IDegAsp in Insulin Naïve or Insulin Treated Subjects with T2DM
This trial is conducted in China. The aim of the trial is to compare the efficacy and safety of GZR101 and insulin degludec/insulin aspart in insulin naïve or insulin treated subjects with type 2 diabetes.
- Trial name
- NCT06199505
- Testing
- GZR101, insulin degledec/insulin aspart
- Where
- China
- Volunteers
- 153 people
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Eye on Diabetes: A Multidisciplinary Patient Education Intervention
Vision loss from diabetes is often preventable with timely detection and treatment. Patients with diabetes may not understand the importance of annual dilated eye examinations or recognize the benefits of early detection of…
- Trial name
- NCT00417924
- Testing
- Patient education
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Nova Southeastern University
Coronary Artery Bypass
Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery
Blood glucose levels increase in response to stress, infection or other conditions faced by patients in the hospital. This occurs commonly among patients with known diabetes, but also among non-diabetic hospitalized patients.
- Trial name
- NCT00394303
- Testing
- Intraoperative continuous insulin infusion, Control
- Where
- Israel
- Volunteers
- 1,400 people
- Sponsor
- Rabin Medical Center
Hypertension, Diabetes Mellitus
CONtrolling Disease Using Inexpensive IT - Hypertension in Diabetes
This project will develop and test a low-cost approach to using health information technology and home monitoring aimed at improving care for chronic conditions, with low barriers to adoption in a wide variety of settings - from…
- Trial name
- CONDUIT-HID (NCT01416766)
- Testing
- Self-monitoring-nurse-primary care provider feedback loop
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of Massachusetts, Worcester
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