Clinical trials: Controlled Hypertension
Hypertension, Adherence, Medication
OUTREACH: Urine Analysis and Antihypertensive Treatment
Non-adherence to antihypertensive treatment is one of the leading causes of suboptimal blood pressure control and translates into increased risk of cardiovascular morbidity and mortality.
- Trial name
- OUTREACH (NCT03293147)
- Testing
- HPLC-MS/MS-guided intervention, Standard care
- Where
- 12 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Manchester
Preterm Birth Complication, Preterm Birth
Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities
The goal of this clinical trial is to learn if a personalized prenatal support program [(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)] works to…
- Conditions
- Preterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, Preeclampsia
- Trial name
- PTBCARE+ (NCT06915428)
- Testing
- Care coordination, Electronic massage, support gift #1
- Where
- United States
- Volunteers
- 1,228 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension, Pulmonary
Safety and Efficacy of Terbogrel in Patients With Primary Pulmonary Hypertension
This study sought to determine whether terbogrel was an effective treatment for primary pulmonary hypertension (PPH) by comparing its efficacy and safety to that of placebo.
- Trial name
- NCT02223481
- Testing
- Terbogrel low dose, Terbogrel high dose
- Volunteers
- 71 people
- Sponsor
- Boehringer Ingelheim
Hypertension
Nutritional Strategy for Blood Pressure Control in Patients With Hypertension (NUPRESS)
Adherence to a healthy dietary pattern is part of the self-care of patients with hypertension, and may contribute substantially to therapeutic target goals as well as to a better quality of life.
- Trial name
- NCT03793881
- Testing
- Nutritional Strategy, Dietary Prescription
- Where
- 8 sites in Brazil
- Volunteers
- 408 people
- Sponsor
- Hospital do Coracao
Primary Open Angle Glaucoma or Ocular Hypertension
Study of Netarsudil Ophthalmic Solution in Japanese/Japanese-American Subjects With Open-angle Glaucoma or Ocular Hypertension
To test the safety and effectiveness of AR-13324 0.02% and 0.04% ophthalmic solution relative to placebo in Japanese/Japanese-American subjects with open-angle glaucoma or ocular hypertension in US.
- Trial name
- NCT03310580
- Testing
- AR-13324 Ophthalmic Solution 0.02%, AR-13324 Ophthalmic Solution 0.04%
- Where
- 40 sites in United States
- Volunteers
- 42 people
- Sponsor
- Aerie Pharmaceuticals
Glaucoma, Trabeculectomy
Innovative Tube Trabeculectomy for Advanced and Refractory Glaucoma: A Randomized Controlled Trial
This study aims to compare the efficacy and safety of a novel surgical technique, Innovative Tube Trabeculectomy (ITT), against conventional trabeculectomy in patients with advanced and refractory glaucoma.
- Conditions
- Glaucoma, Trabeculectomy, Innovative Procedures
- Trial name
- ITT-RCT (NCT07755761)
- Testing
- Innovative Tube Trabeculectomy, Conventional Trabeculectomy
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Benha University
Type 2 Diabetes Mellitus (T2DM), Hypertension
Eating Window and Sleep Disorders on Glycemic Control, Cardiovascular Risk, and Weight Loss
This project aims to offer a quantitative and qualitative nutritional approach, along with educational nutritional guidelines for participants with Non-Communicable Chronic Diseases.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Hypertension, Obesity and Type 2 Diabetes, Cardiovascular Diseases
- Trial name
- NCT06735859
- Testing
- Comparison of eating windows intervention
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
TX000045-003 is a double-blind, randomized, parallel group, placebo-controlled, proof- of-concept (POC) study, evaluating 2 dose regimens of TX000045 over the course of a 24-week treatment period (the APEX study).
- Trial name
- NCT06616974
- Testing
- TX000045- Dose A, TX000045- Dose B
- Where
- 72 sites in United States, Armenia and 15 more
- Volunteers
- 191 people
- Sponsor
- Tectonic Therapeutic
Mild to Moderate Hypertension
Phase II Clinical Study of HRS-9563 in Patients With Mild to Moderate Hypertension
This study aims to evaluate the efficacy and safety of HRS-9563 in patients with mild to moderate hypertension, and to explore its appropriate dosage.
- Trial name
- NCT07297797
- Testing
- HRS-9563 Injection, sodium chloride injection
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Hypertension
A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension (ATHOS Study)
The primary objective of this study was test non-inferiority of telmisartan 80 mg + hydrochlorothiazide (HCTZ) 12.5 mg in comparison to amlodipine 10 mg + HCTZ 12.5 mg in reducing ambulatory systolic blood pressure (SBP) in the…
- Trial name
- NCT00240474
- Testing
- Telmisartan 80 mg + hydrochlorothiazide 12.5 mg, Amlodipine 10 mg + hydrochlorothiazide 12.5 mg
- Where
- 73 sites in Belgium, Denmark and 8 more
- Volunteers
- 1,000 people
- Sponsor
- Boehringer Ingelheim
Essential Hypertension
Effect of DNS Exercises Training on Hypertension
Purpose of the study This study will be conducted to investigate any significant effect of dynamic neuromuscular stabilization training on postural control in patients with essential hypertension.
- Trial name
- NCT05900713
- Testing
- dynamic neuromuscular stabilization training, balance exercises plus diaphragmatic breathing
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Healthy
Multiple-Ascending Dose in Japanese Patients Bridging Study
This study is a randomized, placebo-controlled, multiple-ascending dose study in healthy Japanese and Caucasian subjects.
- Trial name
- NCT05065359
- Testing
- Rodatristat Ethyl 300 mg BID, Rodatristat Ethyl 600 mg BID
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Altavant Sciences GmbH
Hypertension, Resistant to Conventional Therapy
Addition of Homeopathy in Patients With Resistant Arterial Hypertension
Resistant hypertension (RHTN) is a common clinical problem faced by both primary care clinicians and specialists worldwide. Patients with RHTN have higher rates of cardiovascular events and mortality compared with patients with…
- Trial name
- NCT02124473
- Testing
- Homeopathy
- Where
- 2 sites in India
- Volunteers
- 79 people
- Sponsor
- Macmillan Research Group UK
Hypertension,Essential, Prehypertension
The Antihypertensive Effect of Remote Ischemic Conditioning (RIC-HTN).
This study intends to further reveal the antihypertensive effect of LRIC and explore its potential mechanisms.
- Trial name
- NCT04915313
- Testing
- Remote ischemic conditioning (RIC)
- Where
- 3 sites in China
- Volunteers
- 95 people
- Sponsor
- Capital Medical University
Hypertension
Azilsartan in Chinese Patients With Mild and Moderate Hypertension
A phase 3 clinical study to evaluate the safety and efficacy of Azilsartan in Chinese hypertension patients
- Trial name
- NCT02609490
- Testing
- Azilsartan tablets, Olmesartan medoxomil tablets
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Lee's Pharmaceutical Limited
Intradialytic Hypertension
Mechanisms of Increased Ambulatory Blood Pressure in Patients With Intradialytic Hypertension
The purpose of this study is 1) to determine what physiologic factors (extracellular fluid overload or vasoconstriction) contribute more to increased blood pressure levels between dialysis treatments in hemodialysis patients…
- Trial name
- NCT01862497
- Testing
- Carvedilol vs. Prazosin
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension, Pregnancy-Induced, Pre-eclampsia
The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy
To assess the effect of routine doses of ibuprofen on post-partum blood pressure control in women with gestational hypertension (gHTN) or preeclampsia without severe features (preE).
- Trial name
- NCT02891174
- Testing
- Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Michigan
Hypertension
The Standardized Management of Hypertension in Rural Shaanxi
The purpose of the study is to build a prevention and management system of hypertension in rural Shaanxi, China, which tries to use the standardized and economical methods to improve the outcome of chronic cardiovascular diseases.
- Trial name
- NCT04371874
- Testing
- Hydrochlorothiazide, Captopril, Nitrendipine, Aspirin
- Where
- China
- Volunteers
- 1,210 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Preeclampsia, Preeclampsia Severe
Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial
This is an open label, randomized control trial (RCT) in which high risk for pre-eclampsia pregnant subjects will be randomly assigned to either an intervention group (metformin 1 gm twice daily plus aspirin 100 mg per day and…
- Conditions
- Preeclampsia, Preeclampsia Severe, High Risk Pregnancy, Eclampsia
- Trial name
- PREMET (NCT04855513)
- Testing
- Metformin
- Where
- Qatar
- Volunteers
- 414 people
- Sponsor
- Hamad Medical Corporation
Pulmonary Hypertension
The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension
The purpose of this multi-center international trial is to evaluate the safety and effectiveness of adding iloprost or placebo (an inactive substance that contains no active study drug) to sildenafil therapy for pulmonary…
- Trial name
- VISION (NCT00302211)
- Testing
- Inhaled Iloprost (5 μg), Sildenafil, Bosentan
- Volunteers
- 67 people
- Sponsor
- Actelion
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