Clinical trials: Corneal Cross-Linking
Keratoconus, Corneal Cross-Linking
Surface Ablation With Corneal Cross Linking in Mild Keratoconus
Interventional and comparative prospective study: Sixty-nine eyes (38 patients) suffering from keratoconus (stages 1-2 Amsler-Krumeich classification) will be divided into four groups.
- Trial name
- NCT05176171
- Testing
- Photorefractive Keratectomy with Corneal Cross-Linking
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Keratoconus
Topography Versus Non-Topography-Guided PRK With CXL in Keratoconus
To our knowledge, this study is one of the first to compare the visual results of non-topography-guided and topography-guided photorefractive keratectomy (PRK) applying sequential and simultaneous corneal cross-linking (CXL)…
- Trial name
- keratoconus (NCT03890718)
- Testing
- Photorefractive keratectomy in mile keratoconus
- Where
- Iran
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Myopia, Corneal Crosslinking
Advanced Cross Linking for Low-grade Myopia
To evaluate the improvement in myopic refractive error and the corneal endothelial safety with a corneal crosslinking treatment regimen for mild myopia.
- Trial name
- PiXLO2 (NCT03197272)
- Testing
- PiXL
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Umeå University
Amount of Corneal Flattening (Kmax Flattening), Change in the Endothelial Cell Count
Topo-Pachymetric Customized Accelerated Epi-On Vs Accelerated Epi-Off Corneal Cross Linking in Keratoconus Management
The objective of this study is to compare the clinical effectiveness and safety of Topo-Pachymetric Customized Accelerated Epithelium-On (aCFXL) to Standard Accelerated Epithelium-Off (aCXL) Corneal Collagen Cross-Linking in the…
- Trial name
- NCT06549387
- Testing
- Corneal cross linking
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Corneal Ulcers
Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection
This study will evaluate the Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes with Corneal Infection.
- Trial name
- NCT02068430
- Testing
- Riboflavin 0.1%, UV-X™ Illumination System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Stephen Trokel
Keratoconus
Corneal Uptake of Riboflavin Eye Drops
The overall objective of this study is to optimise the corneal cross-linking standard protocol in terms of a more economical use of the resource "medical personnel" and in terms of increased patient participation.
- Trial name
- NCT04062435
- Testing
- Drop application in the inferior fornix, Drop application on the cornea
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Keratoconus, Intraocular Pressure
Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT
To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT.
- Trial name
- NCT07599020
- Testing
- Corvis Machine
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Tanta University
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04667572
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Cornea Associates of Texas
Keratoconus
The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial
It is aimed to investigate the role of supplemental systemic oxygen therapy during accelerated corneal collagen crosslinking (CXL).
- Trial name
- NCT04343326
- Testing
- perform corneal collagen cross linking accelerated and delivery of systemic oxygen, perform corneal collagen cross linking accelerated and without additional oxygen therapy, perform Conventiona corneal collagen cross linking
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Provide Evidence-based Recommendations for Clinicians to Optimize Pain Control After CXL
Pain Relief After Corneal Collagen Cross-Linking
Keratoconus is a progressive corneal ectasia that can lead to significant visual impairment and decreased quality of life. The introduction of corneal cross-linking (CXL) with riboflavin and ultraviolet-A (UVA) light has…
- Trial name
- NCT06212830
- Testing
- Gabapentin, Targin, NSAID
- Where
- Israel
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Keratoconus, Cornea Ectasia
Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking
Corneal ectasia is characterized by irregularity and thinning of the cornea, causing the cornea to bulge forward and cause distorted vision and impaired visual acuity.
- Trial name
- NCT03095235
- Testing
- Dietary riboflavin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Keratoconus
Epithelium-on Cross-linking Versus Observation of Fellow Eyes of Patients With Unilateral Clinically Evident Keratoconus
Keratoconus (KC) is a bilateral asymmetric progressive corneal degenerative disease. The management of young patients, diagnosed with clinically evident KC in one eye and with no clinical signs of KC in the other eye, represents…
- Trial name
- NCT06267495
- Testing
- Epithelium-on corneal cross-linking (epi-on CXL)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Keratoconus
Preoperative Corneal Measurements Estimate the Corrected Distance Visual Acuity After Corneal Cross-linking
This study aims to determine if objective markers describing corneal optical density (COD), thinnest corneal thickness (TCT), anterior (ARC), and posterior (PRC) surface radii over the 3mm thinnest region of the cornea could…
- Trial name
- NCT06522789
- Testing
- corneal cross-linking procedure
- Where
- North Macedonia
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Sistina Ophthalmology Hospital
Keratoconus
Accelerated Corneal Collagen Crosslinking Protocols
To evaluate and compare the effect of pulsed light (pl-ACXL) accelerated and continuous light accelerated (cl-ACXL) epithelium-off cross-linking in halting the progression of keratoconus.
- Trial name
- NCT05693740
- Testing
- Accelerated crosslinking (ACXL)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Keratoconus, Ectasia
UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia
The primary objective of this study is to evaluate two different ultraviolet (UV) dosing regimens for corneal collagen cross linking to slow the progressive changes in corneal curvature in eyes with progressive keratoconus or…
- Conditions
- Keratoconus, Ectasia, Corneal Ectasia
- Trial name
- NCT01325298
- Testing
- UV-X Light, Riboflavin
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mercy Center for Corrective Eye Surgery
Keratoconus
McNeel Eye Center Corneal Crosslinking Study
This study will investigate the effectiveness in treating keratoconus, pellucid marginal degeneration and post LASIK iatrogenic ectasia utilizing fluence rates and treatment times of Corneal Cross Linking other than the original…
- Trial name
- NCT02921009
- Testing
- Crosslinking using UV light of two different fluence rates
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McNeel Eye Center
Progressive Keratoconus, Corneal Ectasia
Corneal Crosslinking in Keratoconus and Corneal Ectasia
Prospective, randomized, single site to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes progressive keratoconus or corneal ectasia.
- Trial name
- CXL (NCT00679666)
- Testing
- Riboflavin
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Keratoconus
Assessment of Corneal Stiffness in Keratoconus After Crosslinking by Corvis ST and OCT.
Objectives: Measurement of corneal stiffness parameters { Deformation Amlitude (DAR1), Integrated radius, Stress parameter (SP A1), Stress strain index (SSI) and Corvis biomechanical index (CBI) } in keratoconic corneas before…
- Trial name
- NCT05161052
- Testing
- Corvis ST (dynamic Scheimpflug technology)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Cairo University
Keratoconus
Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus
This study compares the outcomes of the Vedera KXS procedure (a microwave-based procedure, also known as Keraflex) combined with corneal collagen crosslinking to corneal collagen crosslinking alone for the treatment of…
- Trial name
- NCT01672814
- Testing
- riboflavin ophthalmic solution, Vedera KXS Microwave System
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute