Clinical trials: Corneal Disease
Pellucid Marginal Corneal Degeneration, Keratoconus
A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea
The purpose of this research study is to find out if the new Brillouin Ocular Scanner can measure the variation (difference) of the corneal elastic changes involved in the onset of corneal ectasia, induced by LASIK surgery and…
- Conditions
- Pellucid Marginal Corneal Degeneration, Keratoconus, Keratectasia
- Trial name
- NCT03220529
- Testing
- Brillouin Ocular Scanner
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Refractive Error
Corneal Staining Associated With Daily Disposable Beauty Contact Lenses
Limbal ring contact lenses enhance the look of the eye by adding pigmentation in a ring pattern to the contact lens. The purpose of this investigation is to determine if corneal staining increase is dependent upon the lens…
- Trial name
- NCT01882465
- Testing
- etafilcon A, 2-HEMA, EGDMA Non-ionic, hefilcon A
- Where
- Hong Kong
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Hypotony Ocular, Cornea Folds and Rupture of Bowman's Membrane Both Eyes
Anterior Corneal Striae in Hypotony
The goal of this is to evaluate the biomechanical properties of hypotonous eyes with vertical anterior corneal striae and/or hypotony maculopathy compared to hypotonous eyes without striae.
- Conditions
- Hypotony Ocular, Cornea Folds and Rupture of Bowman's Membrane Both Eyes, Maculopathy
- Trial name
- NCT04023123
- Testing
- Ophthalmic imaging
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Duke University
Dry Eye, Dry Eye Syndromes
Assessment of Tear Production, Corneal Staining, and Comfort Level Wearing Different Types of Contact Lenses
This research assesses the tear performance of five distinct types of soft contact lenses commonly found in the market. The study involves contact lens participants, all of whom are students enrolled at UKM.
- Conditions
- Dry Eye, Dry Eye Syndromes, Contact Lens-induced Corneal Fluorescein Staining
- Trial name
- NCT06351410
- Testing
- Eye Wearing Contact Lens
- Where
- Malaysia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Keratoconus
Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus
The purpose of this study is to investigate changes in corneal innervation during scleral contact lens wear in a keratoconic population.
- Trial name
- NCT03091101
- Testing
- Scleral lens wearing keratoconics
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Myopia, Hyperopia
Daily Wear Corneal Infiltrative Event Study
This DWCIE Study is a prospective cohort study of patients fit to the FDA approved and marketed lotrafilcon A (Ciba Vision, Air Optix Night \& Day Aqua) soft contact lenses for daily wear (DW) with monthly disposal.
- Conditions
- Myopia, Hyperopia, Corneal Infiltrative Events
- Trial name
- DWCIE (NCT00937105)
- Testing
- lotrafilcon A contact lenses, Renu Multiplus, Clear Care
- Where
- United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Myopia, Corneal Crosslinking
Photorefractive Intrastromal Corneal Crosslinking as a Treatment for Low Grade Myopia
To assess the improvement in refractive error and the corneal endothelial safety with a customized corneal crosslinking treatment regimen for low grade myopia.
- Conditions
- Myopia, Corneal Crosslinking, Refractive Errors, Eye Diseases
- Trial name
- NCT03987880
- Testing
- 4.0 mm treatment, 3.5 mm treatment
- Where
- Sweden
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Umeå University
Keratoconus
Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN
Patients with KCN who undergo cornea transplantation divided to 2 groups: Group1: After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea Group 2: After mechanical…
- Trial name
- NCT04130334
- Testing
- After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea, : After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea
- Where
- Iran
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma
Evaluation of Corneal Temperature by Infrared Thermography in Glaucoma Patients
Measurement of corneal temperature gives indirect information about the ocular blood flow. For this reason corneal temperature can be used as a surrogate to quantify ocular blood flow.
- Trial name
- NCT02674074
- Testing
- infrared thermography
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cataract, Pseudophakia
Evaluation Study for a Non-Contact Biometer
The purpose of this study is to determine whether a new non-contact biometer, is as accurate as the the available gold-standard.
- Conditions
- Cataract, Pseudophakia, Myopia, Hyperopia
- Trial name
- NCT00494390
- Where
- Switzerland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Dry Eye Syndrome, Infectious Keratoconjunctivitis
Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface
This study aims to obtain the lacrimal fingerprint for frequent pathologies of the ocular surface and establish a normative base for each of them.
- Conditions
- Dry Eye Syndrome, Infectious Keratoconjunctivitis, Mucous Membrane Pemphigoid, Allergic Conjunctivitis
- Trial name
- EML-MSO (NCT04198740)
- Testing
- Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry
- Where
- 2 sites in Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Keratoconus
A Clinical Study of Keratoconus in Asian Patients and Assessment of Different Topographic Patterns of Keratoconus in Asian Patients
A clinical study of keratoconus in Asian Patients and assessment of different topographic patterns of keratoconus in Asian patients
- Trial name
- NCT00347074
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Artifical Intelligence, Cataract
Development of a Mobile Terminal-Based Intelligent Detection System for Multiple Anterior Segment Diseases of the Eye
This is a multi-center, cross-sectional study evaluating a smartphone-based artificial intelligence (AI) system for anterior segment eye disease screening.
- Conditions
- Artifical Intelligence, Cataract, Pterygium, Keratopathy
- Trial name
- LENS (NCT07634913)
- Testing
- Smartphone-based on-device artificial intelligence system for anterior segment eye disease screening
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Trachoma
Azithromycin in Control of Trachoma II
Trachoma is the world's leading cause of preventable blindness. This disease, caused by Chlamydia trachomatis, is endemic in many parts of the developing world.
- Trial name
- NCT00286026
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Glaucoma Eye
Assessment of the Occuity PM1 Pachymeter
To determine whether the Occuity PM1 device is non-inferior in measuring central corneal thickness when compared to ultrasound pachymetry, the Lenstar and the Pentacam.
- Trial name
- NCT05895617
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Occuity Limited
Cornea, Skin Diseases
OCT Vibrography for Biomechanical Properties of Tissues
The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.
- Conditions
- Cornea, Skin Diseases, Gingival Diseases
- Trial name
- NCT05759780
- Testing
- Optical imaging of the tissues
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Keratoconus, Intraocular Pressure
Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT
To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT.
- Trial name
- NCT07599020
- Testing
- Corvis Machine
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Tanta University
Hyperopia
Safety and Efficacy of the Transform™ Corneal Allograft for Hyperopia Correction
The objective of this clinical study is to evaluate the safety and effectiveness of intrastromal implantation of the Allotex TCA for improving distance vision in hyperopic subjects.
- Trial name
- NCT03671096
- Testing
- Intrastromal TCA Inlay
- Where
- 11 sites in Austria, Belgium and 4 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- Allotex, Inc.
Keratoconus
Accelerated Corneal Collagen Crosslinking Protocols
To evaluate and compare the effect of pulsed light (pl-ACXL) accelerated and continuous light accelerated (cl-ACXL) epithelium-off cross-linking in halting the progression of keratoconus.
- Trial name
- NCT05693740
- Testing
- Accelerated crosslinking (ACXL)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University