Clinical trials: Corneal Transplantation
Limbal Stem Cell Deficiency
Cultivated Autologous Oral Mucosal Epithelial Transplantation
Earlier protocol for cultivated oral mucosal epithelial transplantation (COMET) requires trypsin/EDTA to isolate epithelial cells from tissue, and uses murine 3T3 cells as feeder cells, which results in biosafety concern.
- Trial name
- NCT03943797
- Testing
- Cultivated oral mucosal epithelial cell transplantation
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Corneal Disease, Endothelial Corneal Dystrophy
Developing a Nationwide Registry to Track Longitudinal Clinical Outcomes of Corneal Surgery and Disease
The goal is to develop a nationwide registry to track longitudinal clinical outcomes of and store imaging data related to numerous corneal conditions.
- Conditions
- Corneal Disease, Endothelial Corneal Dystrophy, Corneal Transplant Failure, Corneal Transplant Rejection
- Trial name
- NCT06101017
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Nitin Vaswani
Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.
- Trial name
- STMIK (NCT06233409)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Keratopathy
Immunosuppression After Repeat Keratoplasty
Purpose: To compare the efficacy of topical 0.03% tacrolimus with systemic mycophenolate mofetil (MMF) in preventing corneal allograft rejection after repeat keratoplasty.
- Trial name
- NCT04147390
- Testing
- prescribe topical 0.03 % tacrolimus, prescribe mycophenolate mofetil(MMF)
- Where
- Iran
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Limbal Dermoid
Visual Quality and Contrast Sensitivity Function for Limbal Dermoid Children After Corneal Transplantation
This study is to inquiry the contrast sensitivity function in the 50 eyes of limbal dermoid children with keratoplasty with quick contrast sensitivity function (quick CSF) test, as well asa to analyze its relationship between…
- Trial name
- NCT03447041
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Refractive Error, Corneal Implantation
Piggyback Sulcoflex Toric IOL for Correcting Refractive Error Following Corneal Transplantation
A prospective study to evaluate the safety and efficacy of a piggyback sulcoflex toric intraocular lens in pseudophakic patients for correcting refractive errors following corneal transplantation
- Conditions
- Refractive Error, Corneal Implantation, Intraocular Lens Implantation
- Trial name
- NCT01718184
- Testing
- toric intraocular lens implantation, Sulcoflex intraocular lens implantation
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Persistent Corneal Epithelial Defect
Comparison of Topical Insulin and Amniotic Membrane Transplant for Persistent Corneal Epithelial Defects
After an initial period of standard treatment, they received further care aimed at helping the surface of the eye heal. Clear instructions were given on how to use and store the treatment properly.
- Trial name
- NCT07561398
- Testing
- Topical insulin eye drops, Amniotic Membrane Graft
- Where
- Pakistan
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Al-Shifa Trust Eye Hospital
Corneal Epithelial Defect, Diabetic Retinopathy
Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Ophthalmology ,cornea Autologous serum has long been known to be effective to promote corneal epithelial wound healing in a variety of ocular surface disorders.
- Conditions
- Corneal Epithelial Defect, Diabetic Retinopathy, Penetrating Keratoplasty
- Trial name
- NCT01075347
- Testing
- autologous serum, Non-autologous serum
- Where
- Taiwan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Keratoplasty, Regional Block
Comparative Study Between Dexamethasone Versus Magnesium Sulfate in Medial Episcleral Technique in Keratopalsty Surgeries
The aim of this work is to compare between the effects of addition of Dexamethasone versus magnesium sulfate to local anesthetic mixture in medial episcleral technique in keratoplasty operations
- Trial name
- NCT07847489
- Testing
- Bupivacaine hydrochloride, Dexamethasone, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Glaucoma, Corneal Transplantation
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation.
- Conditions
- Glaucoma, Corneal Transplantation, Inflammation
- Trial name
- AH-Tears (NCT04339907)
- Testing
- Sampling of tears, Sampling of aqueous humor
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Irregular; Contour of Cornea, Keratoconus
Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders
The most common causes for irregular cornea (IC) in hospital contact lens practice are Keratoconus (KC) and related cornea thinning disorders.
- Conditions
- Irregular; Contour of Cornea, Keratoconus, Pellucid Marginal Corneal Degeneration, Injury of Cornea
- Trial name
- NCT02444923
- Testing
- Scleral rigid gas permeable contact lenses (SRGPcl) (Zenlens™), Corneal Rigid gas Permeable contact lenses (CRGPcl) (Rose K2)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- London South Bank University
Hyperopia
Hyperopia Correction Using the NTK Optimal Keratoplasty (Opti-K) System
The purpose of this U.S. Clinical Trial on treatment of sighted eyes is to investigate the safety and effectiveness of optimal keratoplasty (Opti-K™) treatments for hyperopia correction using the NTK Enterprises (NTK) Opti-K…
- Trial name
- NCT01028937
- Testing
- Optimal Keratoplasty
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NTK Enterprises, Inc.
Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty
Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties
This study aims to explore the mechanical properties of the cornea using a non-invasive imaging technique called Brillouin microscopy.
- Conditions
- Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty, Post-Descemet Membrane Endothelial Keratoplasty, Healthy Corneas
- Trial name
- NCT06914817
- Testing
- Brillouin optical scanning system (Intelon Optics) (BOSS)
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Corneal Defect
Evaluating the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects
The subjects of this study were patients who underwent corneal endothelial transplantation,who were randomly divided into 3 groups, 2 groups (0.002% and 0.004% ZKY001 eye drops) and 1 placebo control group.
- Trial name
- NCT04228926
- Testing
- ZKY001 eye drops 0.3g:0.006mg, ZKY001 eye drops 0.3g:0.012mg, ZKY001 simulated eye drops
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Myopia, Astigmatism
Compare Anterior Chamber Biometry in Healthy and Post-LASIK Patients
In this study, the investigators employed Visante-OCT (Carl Zeiss, USA), an anterior chamber optical coherence tomography, to monitor the change of anterior chamber dimensions.
- Trial name
- NCT00838734
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Corneal Epithelial Dystrophy
Transplantation of Tissue Cultured Human Amniotic Epithelial Cells Onto Damaged Ocular Surfaces
To investigate the effect of using tissue cultured human amniotic epithelial cells to re-establish severely damaged ocular surfaces.
- Trial name
- NCT00344708
- Testing
- Transplantation of Tissue-Cultured Human Amniotic Epithelial Cells
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Corneal Transplant, Corneal Crosslinking
A Prospective Clinical Trial Designed to Evaluate the Repeatability and Reproducibility of the Intelon BOSS(tm) System
This is a prospective, open-label, single-site clinical trial designed to evaluate the repeatability and reproducibility of biomechanical imaging by the updated version of the BOSS device.
- Conditions
- Corneal Transplant, Corneal Crosslinking, Healthy Eyes
- Trial name
- NCT05423041
- Testing
- BOSS Imaging
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Intelon Optics, Inc
Corneal Transplantation, Glaucoma and Ocular Hypertension
Endoscopic Assisted Anterior Hyaloid Peeling in Boston Type 1 Keratoprosthesis (KPro-HP-Endo)
Common complications of the Boston keratoprosthesis type 1 (KPro) surgery include retroprosthetic membrane formation, glaucoma, and retinal detachment.
- Conditions
- Corneal Transplantation, Glaucoma and Ocular Hypertension, Postoperative Complications, Vitrectomy
- Trial name
- KPro-HP-Endo (NCT04337944)
- Testing
- Boston keratoprosthesis type 1 and anterior hyaloid membrane peeling assisted by endoscopy
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Corneal Transplantation
Deep Lamellar Endothelial Keratoplasty: Small Incision Technique
The research objectives of this study are to determine if small incision Deep Lamellar Endothelial Keratoplasty (DLEK) is able to further reduce the degree of corneal astigmatism and shorten the time course of corneal topography…
- Trial name
- NCT00345020
- Testing
- Deep Lamellar Endothelial Keratoplasty: Small Incision Technique
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Corneal Sensation Reduced, Corneal Dystrophy
Defining the Operating Parameters for a Rebound-esthesiometer
The purpose of this study is to define the operating parameters for a new method to measure corneal sensitivity.
- Conditions
- Corneal Sensation Reduced, Corneal Dystrophy, Corneal Degeneration, Corneal Transplant Failure
- Trial name
- NCT04384094
- Testing
- Esthesiometer measurement
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icare Finland Oy