Clinical trials: Coronary Arterial Disease
Atherosclerosis
Evaluation of the Neointimal Healing by OCT of the Tapered DES Biomime Morph (TAPER-I Study)
The long and very long stents, although they represent a greater navigability challenge, especially in tortuous and calcified coronary arteries, they have the advantage of providing shorter procedural time, with less contrast…
- Trial name
- TAPER-I (NCT04805619)
- Testing
- Biomime Morph, a tapered drug eluting stent (DES) with hybrid design
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- University of Sao Paulo General Hospital
Stable Angina, Coronary Artery Disease
CCTA, CACS and ECG Stress Testing in Patients With Suspected CAD: Precision Phenotyping and Financial Evaluation
The "DATASET-PRECISE", a 3-arm parallel randomized study, aims to provide new insights in risk stratification of patients with suspected CAD in the Greek population.
- Conditions
- Stable Angina, Coronary Artery Disease, Atherosclerosis, Coronary Artery Calcification
- Trial name
- DATASET (NCT04424121)
- Testing
- CCTA
- Where
- 3 sites in Greece
- Volunteers
- 900 people
- Sponsor
- Aristotle University Of Thessaloniki
Radial Artery Occlusion
Standard vs High Dose of Unfractionated Heparin in the Incidence of Radial Artery Occlusion (DEFINITION) Trial.
Double blind single center clinical trial to compare the incidence of radial artery occlusion (RAO) using standard doses of Unfractionated Heparin (UFH) vs. high doses of UFH.
- Trial name
- DEFINITION (NCT04561648)
- Testing
- Unfractionated Heparin
- Where
- Mexico
- Volunteers
- 1,988 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Coronary Calcification
Effects of Fhytomenadione on Coronary Artery Calcification of Hemodialysis Patients
Until 2013 the reported incidence of chronic kidney disease varied widely between countries, reporting the highest prevalence Taiwan, the region of Jalisco in Mexico and United States, with 458, 421 and 363 individuals per…
- Trial name
- NCT04247087
- Testing
- phytomenadione
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Mexicano del Seguro Social
Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease
Temporary MCS With the iVAC 2L Transaortic Device in High-risk PCI
Patients with coronary artery disease and undergoing high-risk percutaneous coronary intervention (PCI) are at increased risk of hemodynamic instability and poor outcomes.
- Conditions
- Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease, Coronary Artery Disease, Cardiogenic Shock
- Trial name
- POTOK (NCT07149714)
- Testing
- iVAC 2L
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Diabetes Mellitus, Type 2
Effects of Exercise Therapy on Ventricular and Endothelial Function in Patients After Coronary Artery Bypass Surgery
The purpose of this study was (1) to compare the peak exercise capacity and left ventricular diastolic function between patients with and without diabetes and (2) to investigate the interrelation among peak oxygen consumption…
- Trial name
- NCT01990638
- Testing
- exercise capacity test
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- National Taiwan University Hospital
Coronary Arterial Disease (CAD), Calcific Coronary Arteriosclerosis
Evaluation of Calcified Coronary Lesion Preparation With the Naviscore Scoring Balloon
The purpose of this clinical study is to evaluate the effectiveness and safety of a specialized medical device, the Naviscore scoring balloon, in preparing calcified coronary artery narrowings before the implantation of a…
- Trial name
- MILOU (NCT07650578)
- Testing
- Scoring Balloon PTCA Catheter, Non-Compliant (NC) Angioplasty Balloon
- Where
- 14 sites in Belgium, Luxembourg and 2 more
- Volunteers
- 200 people
- Sponsor
- University of Mons
Coronary Artery Disease
Comparison of Efficacy of Ivabradine Versus Metoprolol
Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.
- Trial name
- IMAGE (NCT01755663)
- Testing
- Ivabradine and Metoprolol
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Col. Suthee Panichkul
Atherosclerosis, Coronary Artery Disease
ARISE - Aggressive Reduction of Inflammation Stops Events
To assess the safety and efficacy of AGI-1067, as compared to placebo, in the treatment of vascular inflammation and atherosclerosis by assessing the reduction in cardiovascular events.
- Conditions
- Atherosclerosis, Coronary Artery Disease, Myocardial Infarction, Unstable Angina
- Trial name
- NCT00066898
- Testing
- AGI-1067
- Where
- 219 sites in United States, Canada and 2 more
- Volunteers
- 6,000 people
- Sponsor
- AtheroGenics
Validity, Reliability
Validity and Reliability of the BETY-Biopsychosocial Questionnaire in Individuals With Coronary Artery Disease
Scales for biopsychosocial assessment of coronary artery disease patients are limited. The aim of this study was to evaluate the validity and reliability of the Cognitive Exercise Therapy Approach-Biopsychosocial Questionnaire…
- Trial name
- NCT06480006
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Hacettepe University
Coronary Artery Disease
Study of the Natural History of FFR Guided Percutaneous Coronary Intervention
About 20,000 patients with FFR (Fractional Flow Reserve) will be enrolled and evaluated for the natural history of coronary lesions at 2 years clinical and imaging follow-up.
- Trial name
- IRIS FFR (NCT01366404)
- Where
- 29 sites in South Korea
- Volunteers
- 20,000 people
- Sponsor
- Seung-Jung Park
Stent Restenosis, Coronary Artery Disease
Exercise Training in Coronary Artery Disease Patients After Stenting
To determine the effect of exercise training on cardiac outcomes in coronary artery disease patients after Stenting. There is a need to develop strategies, not only to prevent restenosis but also to improve patients' functional…
- Trial name
- NCT05591365
- Testing
- Structured In-Patient and Home plan, Conventional Therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Coronary Artery Disease, Morphologic Change
IVUS Study for SV Graft: Y-composite vs Aortocoronary Conduit
Left internal thoracic artery (LITA) has been acknowledged as the first graft of choice for coronary artery bypass grafting (CABG).
- Trial name
- CONFIG (NCT04782492)
- Testing
- graft configuration in coronary artery bypass grafting
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Ho Young Hwang
Coronary Artery Disease
A Study to Assess the Bioavailability of Different Formulations of AZD5718 and the Food Effect on the Selected Formulation of AZD5718 in Healthy Volunteers
In this study, the relative bioavailability of different formulations of AZD5718 will be determined in order to compare it with the formulation used in a previous Phase 2a study and confirm appropriate drug exposure.
- Trial name
- NCT03420092
- Testing
- Form 1 of AZD5718 tablets, Form 2 of AZD5718 tablets, Form 3 of AZD5718 tablets
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Preeclampsia
Minimally-invasive Assessment of Cardiac Output in Severe Preeclampsia
Severe preeclampsia often presents with uncontrolled hypertension and therefore requires close monitoring of blood pressure and cardiac performance.
- Trial name
- NCT00465114
- Testing
- Hemodynamic Monitoring
- Where
- Canada
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Coronary Artery Disease
PITT PCI Xience Registry
Stents are devices utilized to treat cholesterol blockages of the coronary (heart) arteries. The introduction of drug-eluting (coated) stents into clinical practice is regarded as a revolutionary breaktrhough, as it has reduced…
- Trial name
- NCT01299207
- Where
- United States
- Volunteers
- 2,506 people
- Sponsor
- University of Pittsburgh
Coronary Arteriosclerosis, Cardiovascular Diseases
Pooling of Cohort Studies on Diet & Coronary Disease
To quantify the role of dietary factors in the etiology of coronary heart disease by pooling data from 10 major prospective studies on diet and coronary heart disease.
- Conditions
- Coronary Arteriosclerosis, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00006309
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Microvascular Coronary Dysfunction
Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women.
- Trial name
- NCT02301663
- Testing
- Handgrip, Altitude simulation, Leg exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Patients Undergoing Coronary Angiography
Study of the Effect of Diabetes on the Incidence and the Extent of Coronary Artery Disease
In the present study the investigators will measure the extent of coronary artery disease via coronary angiography and the correlating risk factors.
- Trial name
- NCT01585948
- Where
- Greece
- Volunteers
- 1,104 people
- Sponsor
- University of Ioannina
Coronary Disease
Reduced Manipulation of the Aorta and Neurobehavioral Outcome Trial
The purpose of this trial is to determine whether aortic manipulation in patients undergoing coronary bypass graft surgery leads to increased incidence of microemboli and subsequent impairment of neurobehavioral function.
- Trial name
- NCT00059319
- Testing
- single aorta clamp with retrograde cardioplegia, multiple aorta clamps with antegrade cardioplegia
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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