Clinical trials: Coronary Artery Bypass
Major Coronary Event, Cerebrovascular Accident
CARDS Is Designed To Show If Lowering Cholesterol With Atorvastatin In Type 2 Diabetics Without CV Disease Reduces The Risk Of CV Events
A study to assess the efficacy of once daily atorvastatin 10 mg versus placebo on cardiovascular endpoints in patients with non-insulin-dependent diabetes mellitus (NIDDM) who have a history of either hypertension, retinopathy…
- Conditions
- Major Coronary Event, Cerebrovascular Accident, Coronary Artery Bypass Graft, Angina, Unstable
- Trial name
- CARDS (NCT00327418)
- Testing
- Atorvastatin
- Where
- 135 sites in United Kingdom
- Volunteers
- 2,800 people
- Sponsor
- Pfizer
Cardiovascular Disease
Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery
To evaluate the efficacy of Hemolink™ in combination with Intraoperative Autologous Donation (IAD) versus control (IAD alone) in facilitating avoidance of allogeneic RBC transfusion during and following primary CABG surgery
- Trial name
- NCT00038454
- Testing
- Hemolink (hemoglobin raffimer IV solution)
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Hemosol
Subclinical Hypothyroidism
Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical Hypothyroidism
The goal of this clinical trial is to find out whether levothyroxine reduces complications and improves the prognosis of patients with subclinical hypothyroidism (SCH) undergoing coronary artery bypass grafting (CABG).
- Trial name
- RepleniSH (NCT07380854)
- Testing
- levothyroxine
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- Seoul National University Bundang Hospital
Coronary Artery Bypass Surgery
A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery
The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents…
- Trial name
- NCT01386229
- Testing
- Ketamine, Etomidate
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Baskent University
Atrial Fibrillation
The Effect of Arrhythmia Surgery on Quality of Life in Patients With Atrial Fibrillation Undergoing Cardiac Surgery
Atrial fibrillation (AF) is connected with an increased morbidity and mortality. In addition, quality of life is diminished due to palpitations, dyspnea, dizziness and syncope.
- Trial name
- NCT00886080
- Testing
- Pulmonary vein isolation using microwave energy
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Ischemic Heart Disease
Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery
The purpose of this study is to analyze the changes in cardiac performance before and after milrinone administration in order to find out whether milrinone improves LV performance in patients undergoing coronary artery bypass…
- Trial name
- NCT04153383
- Testing
- Milrinone Injection
- Volunteers
- 20 people
- Sponsor
- Konkuk University Medical Center
Type 2 Diabetes Mellitus, Cardiovascular Disease
Mechanistic Assessment of the Properties of Saxagliptin in Subjects Undergoing Coronary Artery Bypass Graft Surgery
Individuals with type 2 diabetes mellitus (T2DM) are at increased risk for cardiovascular events (for example, heart attack) and the risk is related to one's overall control of blood glucose levels.
- Trial name
- MAPSS (NCT01765270)
- Testing
- Saxagliptin
- Where
- 10 sites in United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Complication of CABG
Effects of Cardiac Rehabilitation on Postoperatory of Coronary Artery Bypass Graft.
Randomized Clinical Trial to evaluate the use of different techniques of physical therapy on recovery of functional capacity, pulmonary function and respiratory muscle strength in the period of hospital stay after coronary artery…
- Trial name
- NCT01410253
- Testing
- Combination of four techniques of physiotherapy, Combination of three techniques of physiotherapy, Combination of two techniques of physiotherapy
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Elective Off-pump Coronary Artery Bypass Grafting
Relation Between Mixed Venous Oxygen Saturation and Cerebral Oxygen Saturation Measured by Absolute and Relative Near-infrared Spectroscopy During Off-pump Coronary Artery Bypass Grafting.
In this clinical study the investigators compared mixed venous oxygen saturation (SmvO2) with relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Trial name
- NCT01673841
- Testing
- Relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University Hospital, Ghent
Post Opeative Pulmonary Complication
The Effect of Acapella and Incentive Spirometry on Blood Gases and Peak Expiratory Flow Rate After Coronary Artery Bypass Graft.
The goal of this clinical trial is to learn if whether the Acapella and Incentive Spirometry have effect on Blood Gas and Peak Expiratory Flow Rate among patients undergoing Coronary Artery Bypass Graft Surgery.
- Trial name
- NCT07337746
- Testing
- Incentive Spirometry therapy, Acapella therapy
- Where
- 2 sites in Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders
Effects of Cardiopulmonary Bypass (CPB)-Leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function
To test the hypothesis that leukocyte filtering during cardiopulmonary bypass (CPB) might reduce the inflammatory response and protect the lungs against the acute injury
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders, Complications Due to Coronary Artery Bypass Graft
- Trial name
- PulmFunction (NCT01469676)
- Testing
- Filtering group LG-6, Pall Biomedical Products
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Sternal Closure
Sternal Closure With Biologic Bone Cement in Patients Undergoing Coronary Artery Bypass Grafting (CABG)
Median sternotomy has been the standard incision for coronary artery bypass grafting (CABG) in patients undergoing surgery for coronary artery disease.
- Trial name
- NCT01261858
- Testing
- Kryptonite
- Where
- Singapore
- Volunteers
- 64 people
- Sponsor
- National University Heart Centre, Singapore
Coronary Artery Disease, Coronary Artery Bypass
Preload Dependency Evaluation With Stroke Volume Variation During Alveolar Recruitment Manoeuvres
The principal aim is to assess impact of alveolar recruitment manoeuvres (ARM) on stroke volume variation, evaluated by trans-oesophageal echocardiography (TEE).
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Hypovolemia, Anesthesia, General
- Trial name
- PreDeARM (NCT02678559)
- Testing
- tee measurement, flotrac measurement, clearsight measurement
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Coronary Artery Bypass
Study of Roxadustat for Reducing the Incidence of Acute Kidney Injury After Coronary Artery Bypass Grafting
Acute kidney injury is a frequent complication after coronary artery bypass grafting (CABG). Roxadustat is a prolyl hydroxylase inhibitor (PHI) which can stabilize hypoxia-inducible factor (HIF) and improve the hypoxic tolerance…
- Trial name
- NCT05010460
- Testing
- Roxadustat
- Where
- 2 sites in China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Cardioplegia Solution Adverse Reaction
Histidine-Tryptophan-Ketoglutarate Solution Versus Blood Cardioplegia in CABG
Background: In cardiac surgery, myocardial protection is mandatory during cross clamp time followed by reperfusion. Use of cardioplegic solutions preserves myocardial energy stores, hindering electrolyte disturbances and acidosis…
- Trial name
- NCT04203680
- Testing
- HTK cardioplegic solution, blood cardioplegia
- Where
- 2 sites in Egypt
- Volunteers
- 320 people
- Sponsor
- Ain Shams University
Congestive Heart Failure
BMAC Enhanced Coronary Artery Bypass Grafting (CABG)
Injection of concentrated bone marrow cells into the myocardium during CABG procedure.
- Trial name
- NCT01061580
- Testing
- Harvest SmartPReP2 BMAC System
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Harvest Technologies
Coronary Artery Disease
CompArison of PCI in NaTive Arteries Versus ByPAss Grafts In PatieNts With Prior CABG (CAPTAIN)
Coronary atherosclerotic heart disease (CAD) has been considered the leading cause of death in both developed and developing countries.
- Trial name
- NCT05368597
- Testing
- PCI in native vessel or in bypass graft
- Where
- China
- Volunteers
- 1,491 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease
Synergy Between PCI With TAXUS and Cardiac Surgery: SYNTAX Extended Survival
An investigator-driven, retrospective study to compare long-term survival-data (10-year follow-up) of patients with coronary artery disease (CAD), previously enrolled in the SYNTAX trial, who were randomized to percutaneous…
- Trial name
- SYNTAXES (NCT03417050)
- Testing
- No intervention will take place for this retrospective and observational study.
- Volunteers
- 2,636 people
- Sponsor
- Erasmus Medical Center
Stem Cell Transplantation, Ventricular Dysfunction, Left
Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS)
Heart attacks are a leading cause of death in both men and women in the United States. When a person has a heart attack, blood is unable to reach a certain area of the heart, and if the blood supply is not re-established quickly…
- Trial name
- PROMETHEUS (NCT00587990)
- Testing
- Lower dose mesenchymal stem cell (MSC) injection, Higher dose MSC injection
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Joshua M Hare
CABG, Revascularization
Is Total Arterial Revascularization Superior to Multiarterial Grafting in Coronary Artery Bypass Grafting
Retrospective study of adult patients with multivessel disease undergoing isolated coronary artery bypass grafting (CABG) in three centers between January 1st, 2009, and December 31st, 2023.
- Trial name
- NCT06766084
- Testing
- CABG
- Volunteers
- 7,878 people
- Sponsor
- Technion, Israel Institute of Technology
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