Clinical trials: Coronary Artery Chronic Total Occlusion
Chronic Total Occlusion of Coronary Artery
Early and Midterm Outcomes of Intravascular Ultrasound (IVUS) Versus Non-IVUS Guidance in Complex Coronary Chronic Total Occlusion (CTO) Revascularization.
Various CTO percutaneous coronary intervention (PCI) studies defined CTO as as a substantial atherosclerotic blockage with >3 months duration of TIMI (Thrombolysis in Myocardial Infarction) 0 flow other than via collaterals.
- Trial name
- NCT04917432
- Testing
- intravascular ultrasound (IVUS), Conventional CTO PCI (non-IVUS guided)
- Volunteers
- 70 people
- Sponsor
- Assiut University
Chronic Total Occlusion of Coronary Artery
Properties of Myocardial Microcirculation in Patients With Different Pathomorphological Substrates, Before and After Recanalization of Coronary Artery CTO
This study will evaluate the changes in myocardial microcirculatory parameters of the collateral donor artery after recanalization of coronary artery chronic total occlusion.
- Trial name
- NCT04060615
- Testing
- percutaneous coronary intervention
- Where
- Serbia
- Volunteers
- 30 people
- Sponsor
- University of Belgrade
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Israel Satellite Registry
BIOTRONIK - SaFety and Performance Registry for a diabetic patient population with the .bimus Eluting Orsiro Stent System Within daily clinical practice - III
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Diabetes Mellitus Type 1 or 2
- Trial name
- NCT01895712
- Where
- 6 sites in Israel
- Volunteers
- 120 people
- Sponsor
- BIOTRONIK Israel
Coronary Artery Disease, Coronary Occlusion
Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions
The purpose of this study is to investigate the safety and efficacy of drug-coated balloon angioplasty for the treatment of chronic total occlusions patients with chronic total occlusion (CTO) lesion.
- Conditions
- Coronary Artery Disease, Coronary Occlusion, Percutaneous Coronary Intervention, Chronic Total Occlusion of Coronary Artery
- Trial name
- NCT04744571
- Testing
- aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. or coronary balloons, drug-coated balloon
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease, Coronary Disease
Hybrid Sirolimus-eluting Versus Everolimus-eluting Stents for Total Coronary Occlusions
Percutaneous recanalization of total coronary occlusions (TCO) was historically hampered by high rates of restenosis and reocclusion.
- Conditions
- Coronary Artery Disease, Coronary Disease, Coronary Stenosis
- Trial name
- PRISON-IV (NCT01516723)
- Testing
- Hybrid sirolimus- and everolimus-eluting stents (ORSIRO, XIENCE PRIME)
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 330 people
- Sponsor
- R&D Cardiologie
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Hungary Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES)
- Trial name
- NCT01892917
- Where
- 13 sites in Hungary
- Volunteers
- 2,000 people
- Sponsor
- Biotronik Hungária Kft.
Coronary Artery Disease, Coronary Stenosis
Ultrathin DES in Complex PCI Scenarios: the ULTRA a Multicenter Study
ULTRA is a multicenter, observational, retrospective registry, enrolling consecutive patients treated with ultrathin coronary DES (coronary stent with strut thickness < 70 um) for coronary bifurcation lesions, left main disease…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Stent Restenosis, Left Main Coronary Artery Disease
- Trial name
- ULTRA (NCT05205148)
- Testing
- Percutaneous coronary intervention with the following platforms: Orsiro; Mistent; BioMime; Supraflex Cruz
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Chronic Total Occlusion of Coronary Artery
REduction of Contrast Via DyeVert Used in CTO Procedures
The is an observational, prospective study to evaluate the effect of the DyeVert System on contrast volume administration in patients undergoing clinically-indicated chronic total occlusion (CTO) percutaneous coronary…
- Trial name
- REDUCe (NCT03118544)
- Testing
- DyeVert System
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW III Asia Registry Orsiro Stent System
Cliflical evaluation of th' Orsiro LESS 10 diabetic subjects requiring coronary revasculariza t ion with Drug Eluting Stefl ts (DES) .880 subjects will be enrolled in this registry.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Diabetes Mellitus Type 1 or 2
- Trial name
- NCT01941290
- Where
- 19 sites in China, India and 3 more
- Volunteers
- 387 people
- Sponsor
- BIOTRONIK Asia Pacific Pte Ltd
Coronary Artery Diseases
BIOFLOW-III UK Satellite Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02257710
- Testing
- Orsiro
- Where
- 4 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Biotronik UK Ltd.
Chronic Total Occlusion (CTO), Frontal QRS-T Angle
Relationship Between Frontal QRS-T Angle and Collateral Circulation in Coronary Artery Chronic Total Occlusion
Aim of the work: To examine the relationship between collateral circulation and the frontal QRS-T angle in patients with chronic total occlusion (CTO)
- Trial name
- NCT07743437
- Testing
- 12-lead Electrocardiogram (ECG) and Coronary Angiography
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chronic Total Occlusion of Coronary Artery
CrossBoss and Hybrid Registry on Coronary Chronic Total Occlusions
The successful re-opening of a blocked coronary artery has a beneficial effect on the further clinical course (e.g. improvement of clinical symptoms, improved quality of life, increased heart function, etc.).
- Trial name
- RECHARGE (NCT02075372)
- Testing
- Data registration
- Where
- 21 sites in Belgium, France and 2 more
- Volunteers
- 1,177 people
- Sponsor
- Hasselt University
Coronary Artery Diseases
BIOFLOW III Satellite-Italy Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02028728
- Where
- 18 sites in Italy
- Volunteers
- 609 people
- Sponsor
- Biotronik Italia S.p.A.
Chronic Total Occlusions of Coronary Arteries
Randomized Comparison of Optimal Medical Therapy and Percutaneous Recanalization for Chronic Total Occlusion (COMET-CTO)
Several meta analysis comparing successful Percutaneous Coronary Intervention of Chronic Total Occlusion (PCI-CTO) with unsuccessful PCI-CTO showed that there is significant reduction in short-term and long-term mortality.
- Trial name
- NCT02964975
- Testing
- Percutaneous coronary intervention, Optimal medical therapy
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- Clinical Centre of Serbia
Chronic Total Occlusion of Coronary Artery
Evaluating the Use of the CapBuster System for the Crossing of CTO's in Coronary Arteries
Evaluate the safety and effectiveness of the CapBuster System medical device in crossing de novo or restenotic chronic total occlusions in coronary arteries
- Trial name
- NCT05733481
- Testing
- CapBuster System Medical Device for the Crossing of Chronic Total Occlusions in Coronary Arteries
- Volunteers
- 26 people
- Sponsor
- Praxis Medical Devices Ltd
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Belgium Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01831336
- Where
- 8 sites in Belgium
- Volunteers
- 332 people
- Sponsor
- Biotronik Belgium NV
Coronary Artery Disease, Coronary Disease
Sapphire 3 CTO Study
A prospective, open label, multi-center, single arm, observational study designed to evaluate the acute safety and device performance of the Sapphire 3 0.85, 1.0 and 1.25mm diameter coronary dilatation catheter in predilatation…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases
- Trial name
- NCT06358508
- Testing
- Sapphire 3 Coronary Dilatation Catheter
- Where
- 14 sites in United States, Spain
- Volunteers
- 170 people
- Sponsor
- OrbusNeich
Coronary Artery Disease
The Effect of GRAVITY on Physiological Measurements During Invasive Coronary Angiography and Intervention
This is a single centre observational study on the impact of change in patient position and hence gravity, on physiological measurements in coronary arteries.
- Trial name
- GRAVITY (NCT03097172)
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Coronary Artery Disease (CAD), Chronic Total Occlusion of Coronary Artery
Predictors and Long-term Incidence of In-stent Restenosis After Chronic Total Occlusion Percutaneous Coronary Intervention
The goal of this clinical trial is to describe the long-term (≥ 3 years) patency of coronary artery stents following chronic total occlusion percutaneous coronary intervention (CTO PCI).
- Conditions
- Coronary Artery Disease (CAD), Chronic Total Occlusion of Coronary Artery, Chronic Total Occlusion (CTO)
- Trial name
- NCT07473596
- Testing
- chronic total occlusion percutaneous coronary intervention (CTO PCI), coronary computed tomography angiography, invasive coronary angiography
- Where
- Finland
- Volunteers
- 294 people
- Sponsor
- Lauri Mansikkaniemi
Coronary Atherosclerosis Due to Calcified Coronary Lesion, Chronic Total Occlusion of Coronary Artery
The XLIMUS-DES in Very Complex Lesions
Stent delivery failure occurs in 4% of all percutaneous coronary interventions (PCI) and >90% of these failures are due to vessel tortuosity and/or calcification.
- Trial name
- NCT02360020
- Testing
- XLimus
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Clinica Mediterranea