Clinical trials: Coronary Artery Stenoses
Angina Pectoris, Left Ventricular Wall Motion Abnormalities
Intraprocedural Determination of Myocardial Vitality Using 2 Different Imaging Methods
The investigators will compare myocard vitality diagnostics using 2D-Strain echography and MRI.
- Trial name
- NCT01934699
- Testing
- Cardiac ultrasound, MRI scanner
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- RWTH Aachen University
Coronary Artery Stenosis, Myocardial Revascularization
Study of Unprotected Left Main Stenting Versus Bypass Surgery (LE MANS Study)
Unprotected left main coronary artery (ULMCA) stenting, offering restoration of a native flow to left coronary artery, is the subject of intense investigations as a potential alternative to bypass surgery.
- Conditions
- Coronary Artery Stenosis, Myocardial Revascularization, Myocardial Ischemia
- Trial name
- NCT00375063
- Testing
- Percutaneous Coronary Intervention, Coronary Artery Bypass Grafting
- Where
- 5 sites in United States, Poland
- Volunteers
- 130 people
- Sponsor
- Ministry of Science and Higher Education, Poland
Coronary Artery Disease
Evaluation of the Benefit of Exercise Testing for the Diagnosis of Obstruction in the Coronary Arteries of the Heart
The purpose of this study is to determine whether exercise testing can detect an obstruction in a coronary artery, and, thereby, can avoid performing a coronary imaging in some cases.
- Trial name
- DP-Cor-1 (NCT05140434)
- Testing
- Exercise test, Cardiac CT
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Sud Francilien
de Novo or Restenosis Lesions
MedJ-01 Ridaforolimus Eluting Coronary Stent System Trial (JNIR)
MedJ-01 Ridaforolimus Eluting Coronary Stent System is a single use device/drug combination product comprising: A mounted Cobalt Chromium (CoCr) alloy based stent A Rapid Exchange (RX) Coronary System Delivery System A Poly…
- Trial name
- JNIR (NCT02828917)
- Testing
- MedJ-01 Ridaforolimus Eluting Coronary Stent System
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Medinol Ltd.
CT Perfusion
Prognostic Value of CT dynamIc Myocardial Perfusion in Patients With Obstructive Coronary Artery Stenosis
VALIDITY is a prospective, open-label, multicenter, randomized controlled trial （ClinicalTrials.gov number）. The study was designed to evaluate the value of noninvasive anatomic CTA combined with functional CTP for the next…
- Trial name
- VALIDITY (NCT03250455)
- Testing
- CTA CTP, CTA
- Where
- 5 sites in China
- Volunteers
- 1,748 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Coronary Artery Disease, Artificial Intelligence
Evaluation on the Effectiveness and Safety of RuiXin-CoronaryAI for Diagnosis of Coronary Artery Stenosis
With the emergence of advanced technology to date in the artificial intelligence (AI), computer aided diagnosis has gradually gained its popularity in the field of healthcare.
- Conditions
- Coronary Artery Disease, Artificial Intelligence, Coronary Artery Stenosis, CT Angiography
- Trial name
- NCT05320185
- Testing
- RuiXin-CoronaryAI software
- Where
- 3 sites in China
- Volunteers
- 615 people
- Sponsor
- Shenzhen Raysight Intelligent Medical Technology Co., Ltd.
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Coronary Artery Disease, Coronary Restenosis
Absorb BVS vs. Drug Coated Balloon for Treatment Of ISR
AbsorbISR is a randomized, controlled trial, single center, prospective, not blinded to evaluate two strategies of in stent restenosis treatment: Implantation of drug eluting bioresorbable stent scaffold Absorb® vs.
- Trial name
- AbsorbISR (NCT02474485)
- Testing
- BVS Absorb implantation., DEB Sequent Please inflation., Control coronary angiography.
- Where
- Switzerland
- Volunteers
- 53 people
- Sponsor
- SIS Medical AG
Coronary Artery Stenosis
Optimal Predilatation Technique for BVS Implantation
The purpose of this study is to determine the optimal way of predilatation for BVS implantation.
- Trial name
- OPTI-BVS (NCT02946320)
- Testing
- Predilatation with non-compliant balloon, Predilatation with scoring balloon (Scoroflex), Predilatation with cutting balloon (Flextome)
- Volunteers
- 45 people
- Sponsor
- Cardiology Center Agel
Coronary Artery Stenosis
Prospective Multicenter Study to Characterize the REAL-WORLD EVIDENCE Regarding Safety and Performance of the PTCA NC Catheters Family
The purpose of this post market study is to collect clinical data of the Arthesys PTCA NC catheters family during angioplasty intervention of coronary vessels or coronary bypass graft stenosis to support MDR submission.
- Trial name
- NCT05536180
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Arthesys
Coronary Artery Stenosis, Fractional Flow Reserve
A Study to Evaluate Direct Wire Pacing (DWP) for Measuring Fractional Flow Reserve (FFR)
This is a randomized, non-inferiority, crossover investigation comparing the Direct Wire Pacing (DWP) versus standard method to measure Fractional Flow Reserve (FFR) in subjects with FFR indications.
- Trial name
- NCT04970082
- Testing
- FFR DWP, FFR
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Recherche Cardio Vasculaire Alpes
Percutaneous Coronary Intervention, Intravenous Ultrasound
IVUS-FFR Accuracy for Coronary Stenosis
IVUS-FFR Online Accuracy for Coronary Stenosis What is this study testing? This study is testing a new technology called IVUS-FFR , which uses ultrasound imaging inside heart arteries (IVUS) to quickly measure whether a narrowed…
- Conditions
- Percutaneous Coronary Intervention, Intravenous Ultrasound, Coronary Physiology
- Trial name
- IVUS-FFR (NCT07446023)
- Testing
- Ultrasound-Derived Fractional Flow Reserve Computational System
- Where
- China
- Volunteers
- 292 people
- Sponsor
- China National Center for Cardiovascular Diseases
Left Main Coronary Artery Disease
Functional Diagnostic Accuracy of Ultrasonic Flow Ratio in Assessment of Left Main Coronary Artery Stenosis
This is a prospective, observational, single-center study. The main purpose of this study is to evaluate the diagnostic accuracy of offline computational ultrasonic flow ratio (UFR) in predicting functionally significant left…
- Trial name
- FUNCTION II (NCT06053944)
- Testing
- fractional flow reserve (FFR); ultrasonic flow ratio (UFR); intravascular ultrasound (IVUS)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
MCG Algorithm Optimization Study in Patients With Coronary Artery Stenosis
This prospective, multicenter study aims to optimize the Magnetocardiography (MCG) algorithm for detecting myocardial ischemia in patients with coronary artery stenosis.
- Trial name
- NCT07888465
- Volunteers
- 165 people
- Sponsor
- AMCG
Coronary Artery Disease
Diastolic Hyperemia Free Index for Assessment of Moderate Coronary Stenoses
A total of 106 subjects will be enrolled at up to 3 sites. Initial enrollment will occur at Washington University only. After 15 subjects have been enrolled at the primary site and no serious adverse events or protocol events…
- Trial name
- DFRiFR (NCT04019535)
- Testing
- physiological assessment with Volcano Verrata pressure wire (iFR)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Washington University School of Medicine
Coronary Stenosis, Diabetes Mellitus
Paclitaxel Eluting Balloon Versus Drug Eluting Stent in Native Coronary Artery Stenoses of Diabetic Patients
The aim of the study is to compare the efficacy of Paclitaxel-eluting PTCA-balloon dilation (SeQuentTM Please) followed by cobalt-chromium stent (CoroflexTM Blue) deployment versus Paclitaxel-eluting stent (TaxusTM LibertéTM)…
- Trial name
- PEPCAD IV (NCT00462631)
- Testing
- Paclitaxel Eluting Balloon, paclitaxel eluting stent, bare metal stent
- Where
- Malaysia
- Volunteers
- 84 people
- Sponsor
- Heart Centre Rotenburg
Coronary Stenosis
Thin Strut Sirolimus-eluting Stent in All Comers Population vs Everolimus-eluting Stent
The primary objective of this study is to compare the performance of SUPRAFLEX to that of XIENCE in an all-comers patient population with symptomatic ischemic heart disease.
- Trial name
- TALENT (NCT02870140)
- Testing
- SUPRAFLEX, XIENCE
- Where
- 23 sites in Bulgaria, Hungary and 5 more
- Volunteers
- 1,435 people
- Sponsor
- ECRI bv
Coronary Artery Disease, Mitral Valve Insufficiency
Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study
Ambulation following surgery has been found to be beneficial for patients; however, nurses and doctors struggle with getting post-operative, hospitalized patients to walk on their own.
- Conditions
- Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Stenosis, Aortic Valve Regurgitation
- Trial name
- NCT02375282
- Testing
- Ambulation orderly
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Baystate Medical Center
Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
Aortic Stenosis With COmplex PCI (ASCOP) Features Retrospective Registry on Contemporary Management and Outcomes
To describe the prevalence and clinical features of patients with severe aortic stenosis undergoing TAVI and concomitant clinically indicated, complex and/or high-risk PCI
- Conditions
- Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement, Angioplasty, Balloon, Coronary, Coronary Artery Disease
- Trial name
- ASCOP (NCT05750927)
- Testing
- Transcatheter aortic valve intervention (TAVI) and percutaneous coronary intervention (PCI)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Myocardial Infarction, Myocardial Ischemia
18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability
This study is designed as a prospective observational feasibility study. The investigators will study whether vulnerable plaques on OCT (fibrous cap ≤ 70 μm) show a locally increased uptake of 18F-choline on PET-MRI compared to…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT03252990
- Testing
- PET-MRI, Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center