Clinical trials: Coronary Patient
Metabolic Disease, Obesity
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
Background: Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels.
- Conditions
- Metabolic Disease, Obesity, Li-Fraumeni Syndrome, Cardiomyopathy
- Trial name
- NCT01143454
- Testing
- NSR IDE-MRI: Research pulse sequences
- Where
- 3 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Systolic, Ketonemia
Ketones in Heart Failure - Effects on Cardiac Efficiency
Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized…
- Trial name
- NCT03073356
- Testing
- Infusion of 3-OHB
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Coronary Heart Disease, Quality of Life
Evaluation of the Effects of Training at Different Intensities in Coronary Artery Patients
Coronary heart disease (CHD) remains the leading cause of morbidity and mortality in developed countries, accounting for approximately one-third of all deaths in individuals over 35 years of age.
- Conditions
- Coronary Heart Disease, Quality of Life, Functional Capacity, Fatigue
- Trial name
- NCT06474624
- Testing
- Cardio Rehabilitation program, Cycling for 20-30 minutes, Cycling a total of 4 cycles
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Kutahya Health Sciences University
Hypertension,Essential, Systolic Hypertension
Cardiac Neuromodulation Therapy (CNT) "Washout" Sub-Study
This washout protocol is structured as a sub-study for patients willing to participate after finishing the double blind randomised phase of the clinical trial, NCT02837445. Devices will be turned off for a week approximately.
- Trial name
- NCT05086523
- Testing
- Programmable Hypertension Control (BackBeat Moderato), Pacing (BackBeat Moderato)
- Where
- 6 sites in Czechia, Hungary and 1 more
- Volunteers
- 28 people
- Sponsor
- BackBeat Medical Inc
Acute Myocardial Infarction, Congestive Heart Failure
Nicorandil Study to Reduce Cardiac Death After Percutaneous Coronary Intervention (PCI) in Hemodialysis Patients
Survival after invasive coronary revascularization is worse in patients with chronic kidney disease than in those without it. The investigators aimed to examine whether oral administration of nicorandil, a hybrid of nitrate and…
- Trial name
- NCT00848562
- Testing
- Nicorandil
- Where
- Japan
- Volunteers
- 129 people
- Sponsor
- Toujinkai Hospital
Chronic Heart Failure
Patient SELF-management With HemodynamIc Monitoring: Virtual Heart Failure Clinic and Outcomes
To demonstrate that a virtual Heart Failure Clinic (HFC) based on patient self-management using Pulmonary Artery Pressure (PAP) monitoring is superior to usual care of HFC, leads to decreased: hospital admissions for heart…
- Trial name
- SELFIe-HF (NCT04441203)
- Testing
- CardioMems
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Montreal Heart Institute
Acute Graft Rejection, Heart Transplantation
Detection of Acute Graft Rejection in Heart Transplant Patients by Estimation of T2
The investigators propose a simple and non-invasive method to monitor heart transplant patients with MRI. Its diagnostic and prognostic values have already been assessed in two monocentric studies.
- Trial name
- DRAGET (NCT02261870)
- Testing
- MRI T2 quantification
- Where
- 10 sites in France
- Volunteers
- 116 people
- Sponsor
- Central Hospital, Nancy, France
Atrial Fibrillation (AF), Stroke
Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation
The purpose of the ANT-006 study is to evaluate the bleeding profile of abelacimab relative to rivaroxaban in patients with atrial fibrillation (AF) at moderate-to-high risk of stroke.
- Trial name
- AZALEA-TIMI 71 (NCT04755283)
- Testing
- Abelacimab, Rivaroxaban
- Where
- 92 sites in United States, Canada and 5 more
- Volunteers
- 1,287 people
- Sponsor
- Anthos Therapeutics, Inc.
Long QT Syndrome Type 1 or 2
Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients
The aim of the study is to evaluate the best stress exam to unmask long QT in patient with KCNQ1 or KCNH2 mutation without long QT interval in rest electrocardiogram.
- Trial name
- QT long (NCT01745666)
- Testing
- exercise test, Epinephrine test
- Where
- 8 sites in France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Aortic Surgery, Extracorporeal Circulation
Clindamycin as an Alternative to Vancomycin in Patients Undergoing Aortic Cardiac Surgery With Extracorporeal Circulation (ECC)
Antibiotic prophylaxis is essential for all types of cardiac surgery under Extracorporeal Circulation (ECC), in order to reduce the incidence of surgical site infection (SSI).
- Trial name
- CLINDAPASS (NCT07267013)
- Testing
- Clindamycin
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Persistent Atrial Fibrillation
Withdrawal Versus Continuation of Amiodarone in Successfully Treated Patients With Persistent Atrial Fibrillation
Amiodarone is considered to be the most effective antiarrhythmic drug in the prevention of persistent atrial fibrillation. It can however cause many adverse events, both cardiac and non-cardiac.
- Trial name
- WISDOM (NCT00845780)
- Testing
- withdrawal or continuation of amiodarone therapy
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- University Medical Center Groningen
Aortic Stenosis, Severe
Selection of Transcatheter Heart vaLve With Intermediate Sizing in Patients With Severe Aortic Stenosis Treated With Transcatheter Aortic Valve Replacement
Transcatheter aortic valve implantation (TAVI) has evolved into a standard therapy for severe aortic stenosis across all surgical risk profiles, supported by pivotal trials in high- and low-risk populations.
- Trial name
- SELECT TAVR (NCT07689279)
- Testing
- Transcatheter Heart Valve
- Volunteers
- 604 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atrial Fibrillation
Retrospective Registry Providing Baseline Data on the Outcome of Left Atrial (LA) or LA Appendage (LAA) Thrombus in Patients With Nonvalvular Atrial Fibrillation (AF) or Atrial Flutter After Standard of Care (SoC) Anticoagulant Therapy
Thrombus outcome data will be collected retrospectively during 2011-2012 as a historical baseline of SoC with oral VKA (Vitamin K Antagonist(s) for the treatment of patients with nonvalvular AF or atrial flutter documented with…
- Trial name
- CLOT-AF (NCT01928979)
- Testing
- no drug
- Where
- 7 sites in Bulgaria, France and 5 more
- Volunteers
- 160 people
- Sponsor
- Bayer
Heart Failure
Changes in the T-wave Alternans in Patients With Heart Failure Treated Wih Sacubitril-Valsartan
The aim of this study is to know if the Sacubitril-Valsartan treatment improves the T-wave alternans in those patients that begin its treatment, which would indirectly show a lower risk of malignant ventricular arrythmias.
- Trial name
- NCT04185103
- Testing
- Sacubitril-Valsartan
- Where
- 4 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Coronary Artery Stenosis, Coronary Heart Disease
A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis
This study investigates the effective power of angina pectoris after Quick-Acting Heart Reliever and isosorbide dinitrate interventing respectively the patients with moderate coronary stenosis for six months.
- Trial name
- NCT01513070
- Testing
- Quick-Acting Heart Reliever, Isosorbide Dinitrate, Aspirin Enteric-coated Tablets
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Acute Respiratory Distress Syndrome
Fluid Responsiveness Prediction During Prone Position
Predicting fluid responsiveness is primordial when caring for patients with circulatory shock as it allows correction of preload-dependent low cardiac output states, while preserving patients of the deleterious effects of…
- Trial name
- PROLOAD (NCT05898269)
- Testing
- Trendelenburg maneuver, End-expiratory occlusion test (EE OCC), End-expiratory and end-inspiratory occlusion test (EI OCC)
- Where
- 4 sites in France
- Volunteers
- 96 people
- Sponsor
- Hospices Civils de Lyon
Heart Failure, Telemedicine
Effect of Implant-based Telerehabilitation
The TELE-RCT study is a prospective 2 arm randomized controlled trial recruiting patients with an implanted CRT device in Jessa Hospital Hasselt in Belgium.
- Conditions
- Heart Failure, Telemedicine, Cardiac Resynchronisation Therapy
- Trial name
- TELE-CRT (NCT04376983)
- Testing
- Telerehabilitation for patients with a cardiac resynchronisation device
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Hasselt University
ST Elevation (STEMI) Myocardial Infarction
LA Strain in Predicting Early Complication in STEMI After PPCI
The goal of this observational study To evaluate the predictive value of left atrial strain for in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing PPCI.
- Trial name
- NCT07263282
- Testing
- 2D echocardiography
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Decompensated Heart Failure, Volume Overload
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
This study aims to compare two medications, acetazolamide and metolazone, along with loop diuretics, to see which one works better and is safer for patients with ADHF who have volume overload.
- Conditions
- Acute Decompensated Heart Failure, Volume Overload, Edema
- Trial name
- NCT06414759
- Testing
- Acetazolamide, Metolazone, IV Loop Diuretics
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Cairo University
Constipation, Constipation Drug Induced
Naloxegol and Opioid-induced Constipation
This is a double-blind, randomized, placebo-controlled trial to examine the effectiveness of adding one 25mg dose of naloxegol to the cardiac surgery pre-operative regimen.
- Trial name
- NCT03316859
- Testing
- Naloxegol 25 MG
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- TriHealth Inc.
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