Clinical trials: Coronary Physiology
Heart Failure, Diabetes Mellitus
Metabolic Determinants of Cardiac Function
Assessment of cardiac energy metabolism in patients with impaired glucose tolerance
- Trial name
- NCT03386864
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- German Diabetes Center
Atrial Fibrillation, Left Ventricular Failure
Non-invasive Blood Pressure and Cardiac Output Measurement by Using Applanation Tonometry
To evaluate and to validate accuracy, precision and trending ability of blood pressure and cardiac output measurement by applanation tonometry in cardiological patients having: atrial fibrillation severe impaired leftventricular…
- Conditions
- Atrial Fibrillation, Left Ventricular Failure, Left Ventricular Impaired Function, Aortic Valve Stenosis
- Trial name
- NCT02444104
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Kidney Failure, Chronic
Saving Residual Renal Function Among Haemodialysis Patients Receiving Irbesartan
Angiotensin II receptor blockers (ARB) are known to preserve kidney function among patients with kidney diseases and reduced renal function, but not among haemodialysis patients.
- Trial name
- SAFIR (NCT00791830)
- Testing
- Irbesartan
- Where
- 6 sites in Denmark
- Volunteers
- 82 people
- Sponsor
- University of Aarhus
Coronary Artery Disease
A Pharmacodynamic Study Comparing Prasugrel Versus Ticagrelor in Patients Undergoing PCI With CYP2C19 Loss-of-function:
Numerous studies have shown that pharmacodynamics (PD) response profiles vary among clopidogrel treated patients and that individuals with reduced response have an increased risk of recurrent ischemic events.
- Trial name
- NCT02065479
- Testing
- Prasugrel, Ticagrelor
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Florida
Coronary Heart Disease
Clopidogrel Response Evaluation and AnTi-Platelet InterVEntion in High Thrombotic Risk PCI Patients
To identify the high-risk patients who might have in-stent thrombosis after PCI with thromboelastography and to head-to-head compare two intensified antiplatelet therapeutic strategies of double-dosage Clopidogrel and triple…
- Trial name
- CREATIVE (NCT01779401)
- Testing
- Clopidogrel 75mg, Clopidogrel 150mg, Aspirin 100mg
- Where
- 2 sites in China
- Volunteers
- 1,078 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Breast Cancer Radiotherapy Planning
Monaco-Serial Biological Function K-value Index Constraint for Cardiac Dose
Breast cancer is the most common malignant tumor in women globally, with radiotherapy being a crucial adjunctive treatment . However, due to the proximity of the breast radiotherapy target to the heart, there is a dose-effect…
- Trial name
- NCT06796257
- Testing
- radiotherapy planning
- Volunteers
- 51 people
- Sponsor
- Jianjun Lai
Acute Renal Failure
Fenoldopam and Ketanserin for Acute Kidney Failure Prevention After Cardiac Surgery
The purpose of the study is to compare the effect of fenoldopam and ketanserin on kidney function preservation in patients at high risk for renal failure after cardiac surgery.
- Trial name
- NCT00557219
- Testing
- fenoldopam (Corlopam), ketanserin (Sufrexal)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Gdansk
Heart Failure, Asymptomatic Systolic Dysfunction
Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function
The following are done for screening procedures to determine if patients are eligible for this study: blood count, kidney and liver blood tests. Patients will complete a 6-minute walk test.
- Trial name
- NCT00405639
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Heart Block, Heart Block Complete
Effect of Site of Right Ventricular (RV) Pacing on RV Function, Left Ventricular (LV) Dyssynchrony and Contraction Efficiency
To evaluate RV systolic function and LV mechanical dyssynchrony and function in different lead position in the RV during permanent pacemaker implantation by using speckle tracking echocardiography (STE) and 3D volumetric ejection…
- Conditions
- Heart Block, Heart Block Complete, Systolic Function
- Trial name
- NCT06636851
- Testing
- Pacemaker and defibrillator
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- South Valley University
Type 2 Diabetes Mellitus Myocardial Infarction
Ertugliflozin's Effect on Heart Function in Diabetic Patients After Myocardial Infarction
This prospective, randomized, open-label, blinded endpoint (PROBE) trial evaluates the efficacy of early ertugliflozin initiation (10 mg daily) compared to standard care alone on cardiac function in 476 adult patients with type 2…
- Trial name
- NCT07621380
- Testing
- Ertugliflozin 10 mg, Standard AMI Care
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Shanghai Zhongshan Hospital
Myocardial Infarction
Reducing Micro Vascular Dysfunction in Acute Myocardial Infarction by Ticagrelor
The current trial will compare the protective effect of ticagrelor and prasugrel on microvascular dysfunction in patients with revascularized ST elevation myocardial infarction.
- Trial name
- REDUCE-MVI (NCT02422888)
- Testing
- Ticagrelor, Prasugrel
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Amsterdam UMC, location VUmc
Coronary Artery Disease
Tai Chi Exercises on Physical Activity and Pulmonary Function in CABG
To improve the cardiopulmonary endurance in Coronary artery bypass grafting (CABG) patients. Internationally in cardiac hospital facility of cardiac rehabilitation is available to improve the patient's physical activity and…
- Trial name
- NCT03857282
- Testing
- Aerobic Exercises, Tai Chi Exercises
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Ischemia, Myocardial Infarction
Evaluating a New Echocardiography Imaging Procedure for Evaluating Heart Function
Magnetic resonance imaging (MRI) and echocardiography are two imaging methods that are used to obtain pictures of the heart and assess heart function.
- Conditions
- Ischemia, Myocardial Infarction, Ischemic Heart Disease
- Trial name
- NCT00661323
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Hypotension and Shock, Hypoperfusion
Non-invasive Objective Assessment of Hemodynamics in Preterm Neonates
Study type: Prospective Observational trial Study design: Longitudinal Population: Preterm newborns <32 weeks gestational age Hypothesis: The inclusion of non-invasive physiological measures of cardiac output, peripheral…
- Conditions
- Hypotension and Shock, Hypoperfusion, Hemodynamic Instability, Intraventricular Hemorrhage
- Trial name
- NOAH (NCT04538079)
- Testing
- Multimodal objective non-invasive Monitoring
- Where
- Ireland
- Volunteers
- 56 people
- Sponsor
- University College Cork
Congestive Heart Failure, Ventricular Function, Left
Validation of the Gated Blood Pool SPECT: ERNA vs 3D Echo
This research study is designed to evaluate the accuracy of the techniques that are used to analyze heart function. The main purpose of this study is to analyze and compare three different methods of assessment of regional and…
- Trial name
- NCT00576186
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 3 of 7)
NOTE: This is the third of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882542
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Bern
Heart Failure, Congestive
PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00354458
- Testing
- rolofylline
- Volunteers
- 1,102 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Chronic Kidney Diseases
Influence of Exercise in Patients With Chronic Kidney Disease During Hemodialysis
Introduction: Chronic Renal Failure affects a large part of the world population, being characterized by irreversible renal tissue damage, resulting in systemic disturbances that negatively affect the patient's life.
- Trial name
- NCT03556540
- Testing
- physical exercise
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Metodista de Piracicaba
Septic Shock
The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation
The study aims to compare the effects of restrictive fluid management on cardiac dysfunction and vascular integrity in septic shock patients.
- Trial name
- NCT04282252
- Testing
- I.V. SOLUTIONS
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Karolinska Institutet
Atherosclerosis, Diabetes
Effects on Re-endothelialisation With Bydureon Treatment in Type 2 Diabetes Subjects
The aim of the study is to use Exenatide long-acting release (LAR) [Bydureon] to minimize vascular remodeling and neointima formation after Percutaneous Coronary Intervention (PCI) and to accelerate stent endothelialisation.
- Conditions
- Atherosclerosis, Diabetes, Restenosis
- Trial name
- Rebuild (NCT02621489)
- Testing
- Bydureon, Humulin kwickpen, Metformin
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Karolinska Institutet
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