Clinical trials: Cortical Excitability
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Neuropathic Pain, Cortical Excitability
Analysis of Cortical Excitability in Neuropathic Pain
The purpose of this study is to determine whether patients with neuropathic pain has abnormal excitability in somatosensory cortex and abnormal sensory-motor connections.
- Trial name
- NCT00789347
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cortical Activation
Menstrual Cycle TMS Plasticity Pilot
Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females. Aim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS…
- Trial name
- NCT07180654
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cyclic Vomiting Syndrome
Cortical Excitability in Cyclic Vomiting Syndrome
This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain…
- Trial name
- NCT05256160
- Testing
- TMS Paired-Pulse assessment of cortical excitability, Autonomic activity
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Substance Use Disorders
Transcranial Magnetic Stimulation in Substance Use Disorder Patients
To determine the effect of substance use disorder on cortical excitability using transcranial magnetic stimulation (TMS) , it's a scientific study
- Trial name
- NCT06066164
- Testing
- Transcranial magnetic stimulation (TMS)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute and Partial Sleep Deprivation
Cortical Excitability and Decision Making After Total Sleep Deprivation and Sleep Restriction
The investigators examine changes in decision making, vigilance and cortical excitability in healthy male subjects undergoing total acute sleep deprivation (40 hours) on the one hand, and chronic partial sleep restriction (7…
- Trial name
- NCT02305225
- Testing
- Sleep Deprivation
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Christian Baumann
Stroke, Healthy Adults
Comparison of Effects of Mirror Therapy Combined With Neuromuscular Electrical Stimulation or Binaural Beats Stimulation on Cortical Excitability, Heart Rate Variability and Lower Limb Motor Function in Patients With Stroke
This study aims to compare the effects of mirror therapy combined with either neuromuscular electrical stimulation or binaural beat stimulation on post-stroke lower limb motor function recovery.
- Trial name
- NCT06011018
- Testing
- Mirror Therapy, Mirror Therapy + Electrical Stimulation, Mirror Therapy + Binaural Beat
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Systemic Lupus Erythematosus
Fatigue, Depression, and Cortical Excitability in Systemic Lupus
Systemic lupus erythematosus is a chronic inflammatory autoimmune disease with an unknown cause and many challenges. Whilst corticosteroids and effective immunosuppressive therapy have transformed the management of patients with…
- Trial name
- NCT03165682
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy Volunteers
Brain Activity in Time Discrimination and Sensory Input
This study will use repetitive transcranial magnetic stimulation, or rTMS (magnetic stimulation to the brain), to examine how the brain distinguishes between two signals that are spaced very closely in time.
- Trial name
- NCT00726050
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Migraine Disorders
Effects of the Visual Stimulation on the Motor and Visual Cortex in Migraneurs With and Without Aura
The aim of this study is to investigate the motor and visual cortex excitability in response to visual stimulation of migraineurs with and without aura compared to healthy individuals.
- Trial name
- NCT02564822
- Testing
- Visual Stimulation
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Motor Activity
iTBS Methods and Motor Cortex Excitability
In a recent publication by Gamboa et al. 20108 it was shown that extended theta-burst stimulation duration might have reverse effects on cortical excitability when compared to the original Huang et al. 2005 publication.
- Trial name
- NCT03584438
- Testing
- Real iTBS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy
Cortical Excitability, Cognitive Functions, and Peripheral Signaling Molecules
It is widely known that exercise creates structural and functional changes in the brain. Synaptic plasticity develops through exercise, thus improving brain functions.
- Trial name
- NCT05689606
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Parkinson Disease
Effects of Rhythmic Auditory Cueing on Stepping in Place in Patients With Parkinson's Disease
Patients with Parkinson's disease have internal rhythm dysfunction, which may affect the rhythmic movements such as walking. Poor regularity of the rhythmic movement may lead to freezing of gait.
- Trial name
- NCT03271736
- Testing
- Stepping-in-place exercise with external auditory cues, Transcranial magnetic stimulation (TMS)
- Where
- Taiwan
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- HsiuYun Chang
Healthy Male Volunteers
Effects of Lacosamide on Human Motor Cortex Excitability: a Transcranial Magnetic Stimulation Study
This study has been designed to explore dose-depended effects of lacosamide (LCM) on motor cortex excitability with TMS in a randomized, double-blind, placebo-controlled crossover trial in young healthy human subjects, and to…
- Trial name
- NCT01382017
- Testing
- Lacosamide, Carbamazepine
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Kiel
Parkinson's Disease
Effects of RAC With Locomotion Training on Cortical Excitability and Behavior in Patients With PD
In this study, 51 subjects include 17 freezers,17 non-freezers and 17 aged-matched healthy subjects will be recruited. We will compare the cortical excitability, gait performance, and stepping-in-place performance before and…
- Trial name
- NCT03656796
- Testing
- Treadmill training with auditory cues, Treadmill training without auditory cues
- Where
- Taiwan
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Young Adults
Cortical Excitability and Typing Performance After Action Observation and Motor Execution
Goal: This study will aim to investigate the effects of different motor stimulation strategies-motor execution (ME) and action observation (AO)-on cortical excitability and typing performance in healthy individuals.
- Trial name
- NCT07009561
- Testing
- Motor Execution Typing Task, Action Observation of Typing Task
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Healthy Individuals
Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals.
- Trial name
- NCT07026760
- Testing
- Trans-spinal magnetic stimulation (90% MT + 1 Hz), Trans-spinal magnetic stimulation (100% MT + 1 Hz), Trans-spinal magnetic stimulation (110% MT + 1 Hz)
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Movement Disorder, Healthy
Brain Excitability During Self-Paced Voluntary Movements
This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease.
- Trial name
- NCT00017966
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cortical Excitability, Primary Motor Cortex
rTMS Induced Reduction in M1 Excitability
When learning a new skill, much of the improvement comes from small alterations the brain makes with each repetition during practice, but this isn't the only time that improvements are made during the learning process.
- Conditions
- Cortical Excitability, Primary Motor Cortex, Motor Skills
- Trial name
- NCT07588113
- Testing
- rTMS
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Indiana University
Blindness
Brain Plasticity of Verbal Memory in the Blind
This study will examine whether blind people develop changes in the brain that improve memory function. Previous studies have shown that blind people, on average, perform better in memory tasks than sighted people.
- Trial name
- NCT00059189
- Testing
- Magstim Rapid Magnetic Stimulator
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)