Clinical trials: Cortical Excitability
Parkinson' Disease
Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease
A controlled, blinded, and randomized clinical study will be carried out in a large sample of people with Parkinson's disease, where the combined effects of physical exercise and transcranial direct curren stimlation (tDCS) on…
- Trial name
- ExtDCSPARK (NCT07524400)
- Testing
- real tDCS and exercise, Exercise
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Healthy Individuals
Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals.
- Trial name
- NCT07026760
- Testing
- Trans-spinal magnetic stimulation (90% MT + 1 Hz), Trans-spinal magnetic stimulation (100% MT + 1 Hz), Trans-spinal magnetic stimulation (110% MT + 1 Hz)
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Cortical Excitability
TMS-EEG as a Tool to Study the Neuromodulatory Effects of Theta Burst Stimulation
To assess the effect of continuous (cTBS) and intermittent theta burst stimulation (iTBS) stimulation on motor cortex excitability using TMS-EEG.
- Trial name
- NCT05206162
- Testing
- theta burst stimulation
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Glucose Metabolism Disorders
Glucose and Non-Invasive Brain Stimulation
Purpose: In this study, the investigators will delineate how brain network dynamics are modulated by experimentally induced elevated blood glucose levels and examine how glucose levels gate neuronal excitability measured by the…
- Trial name
- NCT04031404
- Testing
- Single-pulse TMS
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Motor Activity
iTBS Methods and Motor Cortex Excitability
In a recent publication by Gamboa et al. 20108 it was shown that extended theta-burst stimulation duration might have reverse effects on cortical excitability when compared to the original Huang et al. 2005 publication.
- Trial name
- NCT03584438
- Testing
- Real iTBS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy, Myoclonic Epilepsy
Effect of Levetiracetam on Brain Excitability
This study will examine the effect of the newly developed anti-epileptic drug, levetiracetam, on excitability of the cortex (surface layer) of the brain.
- Trial name
- NCT00006191
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Corticospinal Excitability, Cortical Activation
LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research.
- Trial name
- LAMI (NCT06478303)
- Testing
- Motor imagery, Action reading, Motor localizer
- Where
- 2 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Anhedonia, Major Depressive Disorder (MDD)
Efficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of Anhedonia
The goal of this proposal is to provide a first assessment of the efficacy of our innovative non-invasive brain stimulation system, kTMP, in the treatment of anhedonia in MDD.
- Trial name
- kTMP Anhedonia (NCT07032428)
- Testing
- A new non-invasive brain stimulation tool
- Volunteers
- 104 people
- Sponsor
- Magnetic Tides
Migraine, Headache Disorders, Primary
A Feasibility Trial of Virtual Reality Neurofeedback for Adolescents With Migraine
The goal of this clinical trial is to learn whether a home-based virtual reality (VR) neurofeedback program is feasible and acceptable for adolescents with migraine.
- Trial name
- INSeRT (NCT07454798)
- Testing
- Immersive Neurofeedback Self-Regulation Training (INSeRT), Virtual Reality Imagery (No Neurofeedback)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Mercy Hospital Kansas City
Cortical Excitability, Brain Stimulation
Neuroplastic Alterations of the Motor Cortex by Caffeine
Caffeine is a psychostimulant drug. It acts as a competitive antagonist at adenosine receptors, which modulate cortical excitability as well.
- Conditions
- Cortical Excitability, Brain Stimulation, Caffeine
- Trial name
- NCT04011670
- Testing
- 200 mg caffeine tablet, Non-active tablet
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Parkinson's Disease
The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease
Parkinson's disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson's disease include the following motor tasks: difficult in initiating movement, performing…
- Trial name
- NCT02037451
- Testing
- rhythmic auditory stimulation
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- Chang Gung University
Healthy
Cortical Pharyngeal Area: Excitability, Facilitation and Plasticity in Healthy Subjects
The aims of this study are in four experimental sessions. The aims are: to characterize the excitability of the cortical pharyngeal area with pharyngeal pressure and electromyograms (EMGs), at rest, in awake healthy subjects; to…
- Trial name
- NCT00213382
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Dystonic Disorders
Transcranial Magnetic Stimulation and Electrical Stimulation of Nerves to Study Focal Dystonia
This study will use transcranial magnetic stimulation (TMS) and electrical stimulation of nerves to examine how the brain controls muscle movement in focal hand dystonia (writer's cramp).
- Trial name
- NCT00050024
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Subjects (HS)
Aftereffects of PES Preconditioned with RTMS on the Human Pharyngeal Motor Cortex
The goal of this interventional study is to optimize the excitatory brain effects of combined neuromodulatory therapies on swallowing areas of the brain.
- Trial name
- NCT06884488
- Testing
- repetitive transcranial magnetic stimulation (Magstim Super Rapid stimulator, The Magstim Company Ltd, Whitland, UK), pharyngeal electrical stimulation (Digitimer model DS7; Welwyn-Garden City, Herts, UK)
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Severe Traumatic Brain Injury, Subarachnoid Hemorrhage
Cortical Excitability in Patients With Severe Brain Injury
The aim of the study is to evaluate the cortical excitability in the severe brain injured patients. We hypothesize that: 1. There is a continuous decrease in intracortical inhibition from healthy subjects to awake patients with…
- Conditions
- Severe Traumatic Brain Injury, Subarachnoid Hemorrhage, Anoxic Brain Injury
- Trial name
- NCT00788723
- Testing
- Transcranial Magnetic Stimulation
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy Male Volunteers
Effects of Lacosamide on Human Motor Cortex Excitability: a Transcranial Magnetic Stimulation Study
This study has been designed to explore dose-depended effects of lacosamide (LCM) on motor cortex excitability with TMS in a randomized, double-blind, placebo-controlled crossover trial in young healthy human subjects, and to…
- Trial name
- NCT01382017
- Testing
- Lacosamide, Carbamazepine
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Kiel
Epilepsy
Cortical Excitability Changes Induced by Retigabine: a Transcranial Magnetic Stimulation Study
The objective of this study is to characterize the effects of a single-dose of retigabine on cortical excitability in healthy subjects, as quantified by means of TMS.
- Trial name
- CERETI (NCT01823159)
- Testing
- retigabine
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Cortical Excitability, Robotized TMS
Cortical Excitability Using Robotised and Neuronavigated Transcranial Magnetic Stimulation
This study has two main goals : to develop the cortcial excitbality (CE) measurement methodology using coupling between transcranial magnetic stimulation (TMS) and physiological recordings such as electroencephalography (EEG) and…
- Trial name
- ROBEXCI (NCT02168413)
- Where
- France
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy
Effect of Vibration Stimulation Applied to Different Frequencies in Cortical Excitability and Muscular Function: Randomised Clinical Trial
The vibration stimulation is regarded as a new method of training and therapy to change afferent parts and cortical projections, which are important for motor control.
- Trial name
- NCT02121093
- Testing
- vibration
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Paraíba
Nicotine Use Disorder
Cortical Excitability and Role of rTMS in Nicotine Use Disorder
Cortical excitability and role of repetitive transcranial magnetic stimulation in nicotine use disorder. Estimation of cortical excitability in heavy smoker patients and determination of role of repetitive transcranial magnetic…
- Trial name
- NCT03264755
- Testing
- Repetitive transcranial magnetic stimulation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University