Clinical trials: Cost-Effectiveness
Major Depressive Disorder
VA Augmentation and Switching Treatments for Improving Depression Outcomes
The overall purpose is to determine research based 'next-steps' for outpatients with major depressive disorder who have not had satisfactory outcomes to standard 'first-step' treatments.
- Trial name
- VAST-D (NCT01421342)
- Testing
- Switching: Bupropion-SR, Augmenting: Antidepressant + Bupropion-SR, Augmenting: Antidepressant + Aripiprazole
- Where
- 35 sites in United States
- Volunteers
- 1,522 people
- Sponsor
- VA Office of Research and Development
Esophageal Achalasia
Snare-assisted POEM for Treatment of Esophageal Achalasia
POEM is a new intervention for the treatment of achalasia and has been reported to relieve the dysphagia symptom effectively. Although the cost of POEM method is less than the method of Laparoscopic Heller Myotomy and…
- Trial name
- NCT02999451
- Testing
- snare-assisted POEM, knife-assisted POEM
- Where
- China
- Volunteers
- 75 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Fever, Anaemia
Acceptability and Cost Effectiveness of Home Based Management of Fever: Different Strategies
Malaria remains a major cause of morbidity and mortality particularly among children < 5 years in Uganda. Due to inaccessibility many children die before they reach the health facility.
- Conditions
- Fever, Anaemia, Malaria
- Trial name
- NCT00259142
- Testing
- Chloroquine, sulphadoxine-pyrimethamine
- Where
- Uganda
- Volunteers
- 1,314 people
- Sponsor
- DBL -Institute for Health Research and Development
Miscarriage, Pregnancy Loss
Cost-utility Analysis of Outpatient Manual Vacuum Aspiration Versus Operating Room Electric Aspiration for the Management of First-trimester Miscarriage
The ASPIR study aims to evaluate the cost-utility of outpatient manual vacuum aspiration compared with operating room electric aspiration for the management of first-trimester miscarriage.
- Conditions
- Miscarriage, Pregnancy Loss, First Trimester Pregnancy
- Trial name
- ASPIR (NCT07732231)
- Testing
- Manual vacuum aspiration (MVA), Electric aspiration (EA)
- Where
- France
- Volunteers
- 860 people
- Sponsor
- Nantes University Hospital
Astigmatism
Astigmatism Management in Cataract Surgery With the AcrySof Toric Intraocular Lens
The purpose of this study is to determine if Toric intraocular lens implantation in cataract surgery is a more efficient and cost-effective treatment of astigmatism than Monofocal intraocular lens implantation.
- Trial name
- NCT01075542
- Testing
- AcrySof Toric intraocular lens, model SN60TT, AcrySof Monofocal IOL, model SN60AT
- Where
- 3 sites in Netherlands
- Volunteers
- 86 people
- Sponsor
- Maastricht University Medical Center
Radius Fracture Distal
Minimal Invasive Volar Plating Versus Cast Immobilization for Treatment of Stable Non-displaced Distal Radial Fractures.
Nondisplaced distal radial fractures are nowadays treated by plaster cast immobilization. In this study, the investigators challenge this classical standard treatment with a surgical solution: minimal invasive volar plating with…
- Trial name
- NCT05015556
- Testing
- Minimal invasive volar plating
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Goorens Chul Ki
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
Nasopharyngeal Carcinoma, Nutritional Support
Effect of Oral Nutritional Supplements on Body Weight Loss of Patients With Nasopharyngeal Carcinoma
Concurrent chemoradiotherapy(CCRT) is the principal treatment for nasopharyngeal carcinoma(NPC). Studies have shown that malnutrition is very common in patients with NPC after chemoradiotherapy.
- Trial name
- NCT04823468
- Testing
- Abbott®Ensure, Intensity Modulated Radiation Therapy, cisplatin
- Where
- 13 sites in China
- Volunteers
- 236 people
- Sponsor
- Jinsheng Hong
Neck Pain, Posterior
Acupuncture Relief for Chronic Neck Pain
This study will assess the feasibility of measuring the effectiveness of "usual care" for chronic neck pain as defined in the protocol, compared with usual care plus acupuncture, for chronic neck pain.
- Trial name
- NCT03859011
- Testing
- Acupuncture
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- 5 Element Institute
Impairment, Diabetes
Assessment of Service and Hearing Dogs
For persons with impairments and certain illnesses the use of service dogs may have positive effect. The effects of using these dogs to assist in every day life need to be studied further.The aim of the study was to assess how…
- Conditions
- Impairment, Diabetes, Epilepsy
- Trial name
- NCT03270592
- Testing
- Service dog
- Volunteers
- 56 people
- Sponsor
- Linkoeping University
Low Back Pain Unresponsive to Non-surgical Care
Cost Effectiveness and Clinical Utility of Cell Saver Use for Two to Three Level Lumbar Fusions
The purpose of this study is to determine the cost-effectiveness of using a cell saver for 2 to 3 level lumbar fusions. A secondary objective is to determine if there will be a decrease in the number of allogenic blood…
- Trial name
- NCT01453309
- Testing
- Cell Saver, No Cell Saver
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Norton Leatherman Spine Center
Chronic Obstructive Pulmonary Disease (COPD)
A Randomized Controlled Trial to Determine Outcome and Cost Effectiveness of Case Management of Chronic Obstructive Pulmonary Disease (COPD) Patients
This randomized controlled trial (RCT) will examine a nurse case management model for patients suffering from chronic obstructive pulmonary disease (COPD) in a Danish municipality, and is performed in order to evaluate the use of…
- Trial name
- NCT01512836
- Testing
- Case Management
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Kronikerenheden Nordjylland
Smoking Cessation
A Cost-effectiveness Study of Nicotine Patches Distributed Through a Quitline
The study is to understand whether distribution of two different supplies of nicotine patches through a telephone quitline has an effect on quit rates. The two different supplies are four vs.
- Trial name
- NCT01889771
- Testing
- Nicotine Patch
- Volunteers
- 1,495 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Myeloid Leukemia
Economic Analysis of Blood Product Transfusions According to the Treatment of Acute Myeloid Leukaemia in the Elderly
Blood transfusion requirement represents one of the most significant cost driver associated with acute myeloid leukemia (AML). In addition to an increase prevalence of co morbidities in older patients, AML in older patients is…
- Trial name
- NCT02845232
- Testing
- Transfusion
- Where
- France
- Volunteers
- 214 people
- Sponsor
- Hospices Civils de Lyon
Stroke
Effects of Group Leisure Activities and Musical Training on Hospital Stroke Rehabilitation.
The goal of this clinical trial is to learn whether adding group leisure activities and musical training can help people recover better after a stroke during their hospital rehabilitation.
- Trial name
- RehArt (NCT07541560)
- Testing
- Standard Intensive Stroke Rehabilitation Program, Music-supported Therapy, Enriched Intervention
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassa
Crohn Disease
Distant Management of Crohn's Disease by Smartphones is Feasible and Effective Additionally it Reduces the Costs
Evaluation of the feasibility, acceptability, patient satisfaction and economic benefits of smartphone video-based telehealth in the management of Crohn's disease patients
- Trial name
- NCT04754620
- Testing
- real time online video visit
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people
- Sponsor
- Kocaeli University
Complications Due to Heart Valve Prosthesis
Cost Effectiveness Analysis In Patients With Heart Valve Prosthesis
The combined Antiplatelet and Anticoagulant treatment decreased thrombus formation and overall mortality. Also the initiation of an efficacious early anticoagulation protocol is important because of its potential impact on the…
- Trial name
- HVP (NCT02022527)
- Testing
- Acetyl Salicylic Acid, Warfarin
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Pharmacoeconomic Unit, Egypt
Cholelithiasis
Cost Effectiveness Analysis of Cholecystectomy, Projected Long Term Outcomes and Complications Evaluation
Participation in this research study does not involve any procedures. Health preference will be ascertained through standard techniques including time-tradeoff, standard gamble, and rating scale to assess risks regarding…
- Trial name
- NOTES (NCT01117415)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Tuberculosis
Tuberculosis Diagnostic Trial of CAD4TB Screening Alone Compared to CAD4TB Screening Combined With a CRP Triage Test, Both Followed by Confirmatory Xpert MTB/RIF Ultra in Communities of Lesotho and South Africa
According to WHO, about 40% of the incident TB cases in 2020 are either under-reported or under-diagnosed causing on one hand major health risks and on the other hand catastrophic financial consequences.
- Trial name
- NCT05526885
- Testing
- CAD4TB, POC-CRP, Xpert MTB/RIF Ultra
- Where
- 2 sites in Lesotho, South Africa
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Klaus Reither
Cervical Cancer
HPV Self-sampling in the General Population
A randomized controlled trial comparing three strategies for cervical cancer screening: direct mailing of HPV self-sampling kit ("Outreach" arm), choice between self-sampling or healthcare provider sampling ("Choice" arm), and…
- Trial name
- MIRABELLE (NCT06749847)
- Testing
- Women receive invitation letter with HPV self-sampling kit, Women receive invitation letter with choice of ordering a free self-sampling kit or visit healthcare provider
- Where
- 2 sites in France
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
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