Clinical trials: Crohn&Amp;#39;s
Inflammatory Bowel Disease, Crohn's Disease (CD)
Standardized Fecal Microbiota Transplantation for Crohn&Apos;s Diseases
The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism.
- Trial name
- NCT01793831
- Testing
- FMT
- Where
- 2 sites in China
- Volunteers
- 800 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Crohns Disease
Protease Regulation and Impact of Sodium as Mechanisms of Inflammation in IBD
The study looks at how eating salt affects gut health in people with Crohn's disease. The aim of the study is to find out whether eating more salt increases the breakdown of proteins in the gut and if this makes inflammation and…
- Trial name
- PRISM-IBD (NCT07169123)
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Inflammatory Bowel Disease (Crohn&Amp;#39;s Disease and Ulcerative Colitis), Fecal Microbiota Transplantation
Efficacy and Mechanism of FMT in the Treatment of Inflammatory Bowel Disease: an Open-label Randomized Controlled Study
This study enrolled 94 patients with UC or CD. Two groups received either 8-week intestinal bacterial transplant capsule therapy or biological therapy, respectively.
- Trial name
- NCT07149441
- Testing
- Fecal microbiota transplantation, infliximab
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Shanghai 10th People's Hospital
Autoimmune Diseases, Ulcerative Colitis
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation.
- Conditions
- Autoimmune Diseases, Ulcerative Colitis, Multiple Sclerosis, Scleroderma
- Trial name
- NCT06587828
- Testing
- Companion blood samples with procedure
- Where
- 11 sites in United States
- Volunteers
- 238 people
- Sponsor
- TScan Therapeutics, Inc.
Crohn's Disease
Feasibility of a Minimally Invasive Diagnostic Algorithm in Suspected Crohn's Disease
The goal of this clinical trial is to learn whether a camera pill examination of the whole bowel can be used to diagnose Crohn's disease instead of colonoscopy and a small bowel examination (either MRI or camera pill) in patients…
- Trial name
- ANDI-3 (NCT06882993)
- Testing
- Panenteric capsule endoscopy, Ileocolonoscopy, MRI enterography
- Where
- 5 sites in Denmark, Sweden
- Volunteers
- 165 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Perianal Crohns Disease
VirtuAl Technology to Improve the Management of Perianal Crohn's (VAMP) - PROSPECTIVE
Crohn's is an inflammatory condition that can affect any part of the gut. Over half a million people in the UK live with Crohn's disease and about a quarter will develop a fistula near their back passage.
- Trial name
- VAMP-PROSPECT (NCT06587646)
- Testing
- Virtual Examination under Anaeastehtic - 3D reconstruction imaging, Standard Care - Written MRI report
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Inflammatory Bowel Disease (Crohn&Amp;#39;s Disease and Ulcerative Colitis)
A Mindfulness-based Stress Reduction Program for IBD
The gut-brain connection is important for good health and when it is disrupted it can worsen existing chronic disease. Studies have shown that chronic stress has negative effects on the gastrointestinal tract such as inflammation…
- Trial name
- MBSRforIBD (NCT07266883)
- Testing
- Mindfulness based stress reduction, Active Control
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Nova Scotia Health Authority
Inflammatory Bowel Disease (IBD), Medication Compliance
Telehealth Monitoring in Inflammatory Bowel Disease: Effects on Medication Compliance, Self-Efficacy, and Quality of Life
This randomized controlled trial aims to evaluate the effect of nurse-led telehealth monitoring on medication adherence, self-efficacy, and quality of life in individuals with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Disease (IBD), Medication Compliance, Quality of Life, Telehealth Monitoring
- Trial name
- NCT06971627
- Testing
- Nurse-led Telehealth Monitoring Program, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University - Cerrahpasa
Inflammatory Bowel Disease (IBD), Crohn&Amp;#39;s Disease (CD)
Evaluating the Shift From Intravenous to Subcutaneous Vedolizumab for Inflammatory Bowel Disease
The goal of this retrospective study is to learn about dosing patterns in patients starting subcutaneous vedolizumab administration and patient outcomes after starting subcutaneous administration.
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn&Amp;#39;s Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07123350
- Testing
- Patient switched from IV vedolizumab to subcutaneous vedolizumab as part of normal patient care
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Crohn's Disease Aggravated, Crohn's Disease in Remission
Ustekinumab and Upadacitinib for Induction and Maintenance Therapy in Patients With Refractory Crohn's Disease: A Multicenter, Randomized, Parallel-Controlled Study
Crohn's disease is a chronic inflammatory bowel disorder characterized primarily by abdominal pain and diarrhea [1,2]. Conventional treatments include corticosteroids and immunosuppressants (such as azathioprine, mercaptopurine…
- Trial name
- NCT07149467
- Testing
- Ustekinumab (approximately 6 mg/kg), Upadacitinib
- Volunteers
- 454 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn&Amp;#39;s, Crohn&Amp;#39;s Disease (CD)
A Double-Blind, Randomized, Placebo-Controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of L2-01 in Subjects With Crohn's Disease
This clinical trial is testing a new treatment called L2-01 in patients with Crohn's Disease, a condition that causes ongoing inflammation of the digestive tract.
- Trial name
- NCT07010926
- Testing
- L2-01 adipose-derived mesenchymal stem cells (MSC)
- Volunteers
- 120 people
- Sponsor
- EL3 Bio, LLC.
Inflammatory Bowel Disease (IBD), Inflammatory Bowel Disease (Crohn&Amp;#39;s Disease and Ulcerative Colitis)
Pilot Study Assessing the Feasibility and Impact of a Remote Adapted Physical Activity Program on Quality of Life in Patients With Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Disease (IBD) is a chronic relapsing condition that affects the gastrointestinal tract and is increasingly diagnosed in adolescents and young adults.
- Trial name
- APIMICI (NCT07191106)
- Testing
- adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- Raincy Montfermeil Hospital Group
Inflammatory Bowel Diseases
Impact of a Human Origin Heat Inactivated Probiotic-Lactobacillus Paracasei D3.5 (LpD3.5) as Dietary Supplement on Gut Mucin and Intestinal Permeability in Adults With IBD
This study aims to study a biological phenomenon of reduced mucin barriers that are linked with increased intestinal permeabil-ity in the gut of individuals with IBD and determine whether and how a human originated, and heat…
- Trial name
- LIBD (NCT07017959)
- Testing
- LpD3.5 supplementation.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of South Florida