Clinical trials: Cytokine
Alopecia Areata
Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5%
It is thought that alopecia areata occurs as the result of an inappropriate response of the body's own immune system to certain substances in or around the hair follicle.
- Trial name
- NCT00176943
- Testing
- Aldara Cream 5%
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hordinsky, Maria K., MD
Non-infectious Uveitis, Periodontal Disease
Periodontal Status and Cytokine Levels in Patients With Non-Infectious Uveitis
This cross-sectional observational study aimed to evaluate periodontal clinical parameters and inflammatory cytokine levels in gingival crevicular fluid (GCF), saliva, and serum in patients with non-infectious uveitis (NIU)…
- Trial name
- NIU-PERIO (NCT07480291)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Inflammation, Infection
Vitamin D Status Impacts Inflammation and Risk of Infections During Pregnancy
The goal of this study is to characterize the function and efficacy of the bioactive nutrient, vitamin D, in relation to infection and inflammatory status across pregnancy.
- Trial name
- NCT01815047
- Testing
- Vitamin D3 Supplementation
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Cornell University
Postmenopausal Symptoms, Cardiovascular Diseases
Estrogen Deficiency on Cardiovascular Risk
To explore how estrogen deficiency impacts the blood pressure (BP) and sympathetic nerve activity (SNA), and how it impacts the production of the key pro-inflammatory mediators such as Tumor necrosis factor α (TNF-α)…
- Trial name
- NCT06369363
- Testing
- Estradiol
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Orthodontic Tooth Movement
Gingival Crevicular Fluid Cytokine Levels in Response to Orthodontic Forces
The aim of this randomized split-mouth study was to quantify simultaneously 30 analytes including cytokines, chemokines and growth factors in gingival crevicular fluid (GCF) in response to different magnitudes of forces during…
- Trial name
- GCF (NCT03555747)
- Testing
- Canine distalization
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Post-COVID-19, Healthy Participants
Effects of Post-COVID-19 on Quadriceps Femoral Muscle-tendon Unit
The physiological/biomechanical characteristics related to muscle and tendon architecture and their possible relationship with the loss of muscle strength and fatigue in patients who were infected with COVID-19 are totally…
- Trial name
- NCT04961255
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Pressure Ulcers, Bedsores, Decubitus Ulcer
Measurement of Cytokines (IL-1α) After Shear- Force Application at the Skin
Background: A pressure ulcer is localized tissue injury to the superficial layer of the skin and/ or the underlying tissue. Pressure ulcers are most likely to develop in skin areas exposed to pressure, shear and friction.
- Trial name
- NCT02020655
- Testing
- Shear- force model
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Autoimmune Diabetes
Autoimmune Diabetes: Markers of the Disease and Treatment of Latent Autoimmune Diabetes in Adults (LADA)
Autoimmunity is the main cause of diabetes type 1 and an important factor as cause of Latent Autoimmune Diabetes in Adults (LADA).
- Trial name
- NCT01148238
- Volunteers
- healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Periodontitis, Obesity (Body Mass Index >30 kg/m2)
Obesity and Clinical and Cytokine Responses to Periodontal Therapy
This prospective controlled clinical study included 80 participants allocated into four groups according to body mass index (BMI) and periodontal status: obese periodontitis, normal-weight periodontitis, obese periodontally…
- Trial name
- NCT07869277
- Testing
- Scaling and Root Planing (SRP)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emine Çifcibaşı
Sepsis
Cortisol Control of Human Inflammatory Responses to Endotoxin
The purpose of the research is to study a common and dangerous medical condition called 'septic shock' that often occurs in critically ill patients.
- Trial name
- NCT00396344
- Testing
- Çontrol, Hydrocortisone
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Osteoathritis and Sleep
Changes Of Sleep on the Sensoriomotor and Cytokine In Patients With Osteoarthritis
Osteoarthritis (OA) is one of the major health problems and their prevalence has increased in recent decades. It has been shown that OA causes negative effects on sleep and that these changes in sleep see to be correlated with…
- Trial name
- NCT01422967
- Testing
- Balance and muscle strength
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Prebiotics Effect
Prebiotics Change Microflora and Decrease LPS
The purpose of the present study was to establish the prebiotic effect of a new xylo-oligosaccharides (XOS) and of an inulin-and-XOS mixture (INU-XOS) and to determine their effect on endotoxaemia (lipopolysaccharides (LPS)) and…
- Trial name
- PIB (NCT02287844)
- Testing
- XOS, INU-XOS
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Multiple Sclerosis
Mechanistic Study of Ocrevus
The purpose of this study is to investigate the immune cell and other factor changes with Ocrevus in Multiple Sclerosis (MS) patients. Researchers will recruit 35 participants for this study.
- Trial name
- NCT04459988
- Testing
- Ocrelizumab
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Michigan
NMO Spectrum Disorder, Azathioprine Adverse Reaction
Monitoring of Azathioprine Metabolite Concentrations and Cytokine Levels in Neuromyelitis Optica Spectrum Disorder
Background: The pathogenesis of NMOSD has been linked to the cytokines interleukins (IL) -6, NOD-, LRR-and pyrin domain-containing 3 (NLRP3) and IL-18 that contribute to development of inflammatory reactionsmay.
- Trial name
- NCT05896605
- Testing
- Azathioprine
- Where
- China
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Healthy
A First-in-Human Study of BNZ132-1-40
This is an open-label, single ascending dose study to characterize the safety and PK/PD profile of IV BNZ132-1-40, a novel peptide inhibitor of multiple cytokines in the IL-2 family.
- Trial name
- NCT03046459
- Testing
- BNZ132-1-40
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bioniz Therapeutics
Lung Diseases, Obstructive
Cigarette Smoke Nasal and Whole Blood Challenge in Patients With Chronic Obstructive Pulmonary Disease (COPD)
This is a clinical research study to assess whether after exhaling a single cigarette smoke through the nose there are changes in the inflammatory cells and proteins of nasal secretions.
- Trial name
- NCT00159341
- Testing
- Nasal lavage, Nasal filter paper, Blood sampling
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obstructive Sleep Apnea of Child
Cytokine Persistence as a Marker of Inflammation in the at Risk, Low Socioeconomic Status Pediatric Population
The investigators wish to study the role of persistent markers of inflammation in executive function in young children during critical periods of synaptogenesis (ages 2-3).
- Trial name
- NCT03134300
- Testing
- Cytokine from blood
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Kidney Transplantation, Liver Transplantation
Cytokine Kinetics Test to Assess the Presence or Absence of Tolerance in Organ Transplant
The purpose of this pilot study is to determine if there is clinical correlation between the CKT and transplant recipients who are known to be on minimal or no immunosuppression (presumed tolerant) and those who are on…
- Trial name
- NCT00585858
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Decay, Dental, Missing Teeth
Relationship Between Oral Findings and Salivary Factors in Sars-Cov-2 Patients
Two hundred individuals will be formed according to the study and control groups: Group-1: coronavirus 2 (Covid-19) (+) patients (n=100) and Group-2: Healthy individuals (in which the volunteers will be included due to group-1)…
- Conditions
- Decay, Dental, Missing Teeth, COVID-19, Cytokine Storm
- Trial name
- NCT05476848
- Testing
- ELISA test for Cytokines
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Ege University
Contrast Agent, Endothelial Function
The Effect of Contrast Agent on Endothelial Function in Healthy Men
Contrast medium is essential for diagnosis of many diseases. However, recent studies showed that contrast agents can induce renal injury and is associated with poor long-term clinical outcome, especially in diabetes.
- Conditions
- Contrast Agent, Endothelial Function, Cytokines, Apoptosis of Endothelial Progenitor Cell
- Trial name
- NCT01895699
- Testing
- Contrast agent
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da