Clinical trials: Debility
Arthritis, Rheumatoid, Muscular Weakness
Neuromusuclar Adaptations in the Rheumatoid Arthritis Disease
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint inflammation and progressive joint destruction. Rheumatoid cachexia is one of the structural manifestations of RA, and consists of a reduction in muscle…
- Trial name
- NCT03543488
- Testing
- Neuromuscular and functional capacity tests
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Weakness Acquired in the ICU, Muscle Wasting
Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients
This cross-sectional study aims to investigate the relationship between variations in muscle thickness and subcutaneous tissue, measured by ultrasound, and fluid compartments, evaluated using bioelectrical impedance analysis…
- Conditions
- Weakness Acquired in the ICU, Muscle Wasting, Edema, Fluid Overload
- Trial name
- NCT06697470
- Testing
- Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Dr F Duprez
Hypertension
Influence of Respiratory Muscle Training in Elderly Hypertensive Women With Respiratory Muscle Weakness
This study aims to evaluate pulmonary function and respiratory muscle strength in a group of elderly women with hypertension before and after a respiratory muscle training.
- Trial name
- NCT01743183
- Testing
- Threshold
- Where
- Brazil
- Volunteers
- 4 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
COPD, Muscle Weakness
Feasibility of Strength Training in Patients Hospitalized Due to COPD
To examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in COPD
- Trial name
- NCT01981200
- Testing
- Resistance training in AECOPD
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Frederikssunds Hospital, Denmark
Primary Progressive Multiple Sclerosis, Hemiparesis
Video Game-based Therapy for Arm Weakness In Progressive Multiple Sclerosis
Participants will receive intensive therapy through a video game in their own homes for 1 month. The game is operated by movements of the body (no controller needed) and acts like a virtual therapist.
- Trial name
- NCT03094364
- Testing
- Gaming CI Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Massachusetts, Lowell
Hamstring Injury, Muscle Tone Increased
Cranial Laser Reflex Technique for Hamstring Function
Purpose: To conduct a pilot study of the effect of Cranial Laser Reflex Technique (CLRT) compared with sham laser on hamstring muscle flexibility, strength, and pain pressure threshold.
- Conditions
- Hamstring Injury, Muscle Tone Increased, Muscle Pain, Muscle Weakness
- Trial name
- CLRTHam (NCT03044106)
- Testing
- CLRT
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Muscle Weakness
Electrical Stimulation to Strengthen Muscles in the Lower Legs in Patients Requiring Prolonged Mechanical Ventilation
The primary aim of this proposal is to test the effectiveness of NMES in improving functional status and muscle function in patients requirng prolonged mechanical ventilation
- Trial name
- NCT01825135
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- RML Specialty Hospital
ICU Acquired Weakness, Muscle Atrophy
Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )
Intensive Care Unit Acquired Weakness (ICUAW) describes muscle weakness that occurs in around 40% of patients during an intensive care stay.
- Conditions
- ICU Acquired Weakness, Muscle Atrophy, Energy Malnutrition Protein, Quality of Life
- Trial name
- NCT05919940
- Testing
- Dietary Supplement: additional substitution of protein, Neuromuscular electrical stimulation, Early Mobilization
- Where
- 4 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Low Back Pain, Muscle Weakness
NASM OPT for Gluteal Enhancement in Non-Athletic Women: An RCT
This RCT evaluates a 12-week NASM OPT program targeting gluteal muscle strength, hip aesthetics (shape, lift, circumference), and low back pain in 120 non-athletic women.
- Conditions
- Low Back Pain, Muscle Weakness, Body Image Disturbance
- Trial name
- GlutealEnhan (NCT06977958)
- Testing
- NASM OPT Group, General Exercise Group
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Breast Cancer
Design and Evaluation of the Effects of a Physical Therapy Program With Digital Support in Patients With Breast Cancer
Breast cancer surgery usually results in reduced range of motion of the shoulder joint, weakness of the musculature and altered scapular kinematics during movement.
- Trial name
- NCT04837248
- Testing
- Active Comparator: Group 1. Conventional treatment, Experimental: Group 2. Experimental treatment.
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Arthropathy of Hip, Hip Arthropathy
Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach.
- Conditions
- Arthropathy of Hip, Hip Arthropathy, Locoregional Anesthesia, Complication of Anesthesia
- Trial name
- Peng_lfcn/WI (NCT07284615)
- Testing
- PENG plus LFCN block, PENG plus WI
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Ospedale Edoardo Bassini
Neck of Femur Fracture
PENG Versus Femoral Nerve Block in Neck of Femur Fracture
Neck of femur (NOF) fracture is a common presentation to the emergency department, particularly in our older population. NOF fracture is associated with a high social and economic cost with significant effects on patients'…
- Trial name
- NCT05002725
- Testing
- Lidocain
- Where
- Ireland
- Volunteers
- 64 people
- Sponsor
- University College Cork
Critical Illness
The Role of NEMS for Post ICU Rehabilitation
The purpose of this study is to investigate the role of NEMS as a rehabilitation tool for muscle weakness following critical illness.
- Trial name
- NCT01717833
- Testing
- NEMS
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Athens
Anterior Cruciate Ligament Injuries, Muscle Weakness
Changes in the Force-velocity Relationship of Knee Muscles After ACL Reconstruction
Anterior cruciate ligament (ACL) tear is a frequent and devastating injury in sport, especially in pivoting-contact disciplines.
- Trial name
- FoVeA (NCT05712109)
- Testing
- Follow-up after Anterior cruciate ligament reconstruction
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Caen
Stability, Old Age; Debility
The Feasibility of a Dynamic Exercise Intervention. Psychosocial Effects and Process Evaluation of the Experimental Design.
Current balance and stability interventions have been shown to improve balance through targeting balance impairments and retraining effects.
- Conditions
- Stability, Old Age; Debility, Balance; Distorted
- Trial name
- NCT04932408
- Testing
- Evaluation of the feasibility, psychosocial effects, influence and perception of exercise selection an experimental design of exercises performed at the hip and chest region.
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Derby
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Muscle Weakness, Dynapenia
Mirror Neurons in Older Participants
A critical problem facing aging adults is muscle weakness. Whereas scientists have traditionally attributed the loss of muscle strength with aging to muscle atrophy, emerging evidence suggests that impairments in the…
- Conditions
- Muscle Weakness, Dynapenia, Sarcopenia
- Trial name
- MNOP (NCT03946709)
- Testing
- Action Observation
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Cardiac Diseases, Muscular Weakness
Biomarker for Pompe Disease (BioPompe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Pompe disease from blood (plasma)
- Conditions
- Cardiac Diseases, Muscular Weakness, Hepato-splenomegaly, Lung Disease
- Trial name
- BioPompe (NCT01457443)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Healthy Subjects
Study to Assess the Effect of a CYP3A Weak Inducer Rufinamide on Quizartinib Pharmacokinetics in Healthy Subjects
This study will evaluate the effect of CYP3A weak inducer rufinamide on the pharmacokinetics (PK) of Quizartinib in healthy subjects
- Trial name
- NCT06740825
- Testing
- Quizartinib, Rufinamide
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Old Age; Dementia, Old Age; Debility
Significant Activities in the Integrated Person-centered Care Model
The increasing life expectancy and global aging population necessitate changes in long-term gerontological services based on Person-Centred Care approaches.
- Trial name
- IO/20240924 (NCT06623864)
- Testing
- meaningful activities, other activities
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad de Burgos