Clinical trials: Decreased Vascular Flow
PreDiabetes
Study: Diet and Exercise Study to Improve Brain Blood Flow: Blood Flow Improvement Trial
Project Summary Metabolic syndrome (MetS) is associated with the development of diabetes and cardiovascular disease; however it is also linked with cognitive decline and dementia.
- Trial name
- BFIT (NCT03117829)
- Testing
- Diet and Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Borderline High LDL-cholesterol
Effects of Ubiquinol and Ubiquinone on Vascular Function in Healthy Adults With Borderline High LDL-Cholesterol
This randomized, double-blind, placebo-controlled clinical trial will evaluate the effects of Ubiquinol and Ubiquinone on vascular endothelial function in generally healthy adults with borderline high LDL-cholesterol.
- Trial name
- NCT07881601
- Testing
- Ubiquinol, Ubiquinone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Type 2 Diabetes
Effect of Angiotensin Converting Enzyme Inhibitor, Lisinopril, on Renal Blood Flow and Its Correlation With Proteinuria Reduction in Subjects With Type 2 Diabetes and Kidney Disease
The purpose of the study is to investigate the effect of a blood pressure medication, Lisinopril, or similar drugs in that class, on the flow of blood to the kidneys.
- Trial name
- NCT01101269
- Testing
- ACEI or ARB, Lisinopril
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Anastomotic Leak
Quantification of Anastomostic Blood Flow With Fluorescence Imaging in Low Anterior Resection for Rectal Cancer
A serious and life-threatening complication to rectal surgery is anastomotic leakage, AL. In Denmark, approximately 800 patients every year, are operated for rectal cancer, 50% of these with resection and anastomosis.
- Trial name
- FILAR (NCT05627934)
- Testing
- qICG
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Decreased Vascular Flow
Interferential Electrical Stimulation and Vasodilatation in Healthy Individuals
Interferential electrical stimulation (IES) increases local blood flow. It is not known whether increases in blood flow may be caused by inhibition of sympathetic activity, mediated by muscle metaboreflex activity.
- Trial name
- InterM (NCT01450371)
- Testing
- Interferential
- Where
- 3 sites in Brazil
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Physiology, Ocular, Microcirculation
Role of Nitrogen Oxide (NO) in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. For a long time it had been assumed that the choroid is a strictly passive vascular bed, which shows no autoregulation.
- Conditions
- Physiology, Ocular, Microcirculation, Regional Blood Flow, Autoregulation
- Trial name
- NCT00810927
- Testing
- Suction cup application, Laser Doppler flowmetry, Measurement of intraocular pressure
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Citrulline, Blood Flow
Effect of L-Citrulline on Vascular Function
The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.
- Conditions
- Citrulline, Blood Flow, Aging
- Trial name
- NCT03127917
- Testing
- L-citrulline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Decreased Vascular Flow
Optic Nerve Head Autoregulation During Changes in Arterial Blood Pressure
Constant despite changes in perfusion pressure. It is observed in many vascular beds of the human body to prevent that variations in perfusion pressure are directly transmitted into changes in blood flow.
- Trial name
- NCT01663883
- Testing
- Isometric exercise
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Adolescent Athletic Performance, Muscle Strength Development
Effects of Back Squat Exercise with or Without Blood Flow Restriction in Healthy Adolescent Basketball Athletes
The goal of this clinical trial is to assess the effectiveness of Blood Flow Restriction (BFR) training compared to traditional high-intensity training in adolescent basketball players aged 16-18.
- Conditions
- Adolescent Athletic Performance, Muscle Strength Development, Jump Height Improvement, Ground Reaction Force (GRF) Enhancement
- Trial name
- BFR (NCT06684093)
- Testing
- Back squat with Blood flow restriction machine, Back squats
- Where
- Lebanon
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- St Joseph University, Beirut, Lebanon
Reduction of Blood Flow
Effects of Functional Electrical Stimulation on Metaboreflex Activation in Healthy Individuals
Cardiovascular exercise adjustments are required during in order to redistribute blood flow from non-exercising vascular areas to active muscles.
- Trial name
- NCT02448030
- Testing
- Functional electric stimulation, Isometric exercise
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Ocular Physiology, Regional Blood Flow
Effects of Vitamin C on Hyperoxia-Induced Reduction of Retinal Blood Flow
High arterial blood oxygen tension leads to vasoconstriction of retinal vessels, possibly related to an interaction between reactive oxygen species and endothelium-derived vasoactive factors.
- Trial name
- NCT00712907
- Testing
- vitamin C (Mayrhofer) 24mg/min i.v. for 64 min, 100% O2 (AGA) two times for 12 min
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity, Endothelial Dysfunction
Effects of Body Mass Index on the Hyperemic Response to Regadenoson
We will test the hypothesis that a single dose of Regadenoson will produce equivalent degrees of coronary hyperemia in patients of widely different body size.
- Conditions
- Obesity, Endothelial Dysfunction, Decreased Vascular Flow
- Trial name
- NCT00859833
- Testing
- Adenosine, Regadenoson
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Raynaud's Disease
Nova Cold Hands Raynaud's Disorder, a Disease Which Results in Decreased Blood Flow to the Hands and Feet.
Patients presenting to UIC rheumatology clinic with Raynaud's disorder and scleroderma will be asked to participate. 10 hands of patients with both Raynaud's disorder and scleroderma will be studied.
- Trial name
- NCT02615964
- Testing
- Nova Flow Procedure
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Anaerobic Performance
High-Load Blood Flow Restriction (BFR) Training May Decrease Anaerobic Fatigue in Distance Runners
This study investigates the effects of high-load BFR training on anaerobic performance and fatigue resistance in distance runners.
- Trial name
- BFR-Training (NCT06822595)
- Testing
- Blood flow restriction (BFR) training, Isokinetic training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital