Clinical trials: Defect Limb
Wound of Skin, Ulcers
TrueLok Elevate PMCF Study
The TrueLok Elevate Transverse Bone Transport System is a modular external fixation device designed for transverse bone transport.
- Conditions
- Wound of Skin, Ulcers, Soft Tissue Defect
- Trial name
- NCT07079774
- Testing
- Transverse Bone Transport System
- Where
- 14 sites in Germany, Italy and 4 more
- Volunteers
- 153 people
- Sponsor
- Orthofix s.r.l.
Wound of Skin, Non-melanoma Skin Cancer
Efficacy and Safety of a Nanofat-seeded Biological Scaffold in Healing Lower Limb Surgical Defects
Large full-thickness skin defects, such as those resulting from trauma, large and giant congenital nevi, disfiguring scars, or tumor resection remain major clinical problems to patients and physicians.
- Conditions
- Wound of Skin, Non-melanoma Skin Cancer, Skin Graft Complications, Wound of Lower Leg
- Trial name
- NCT03548610
- Testing
- Nanofat-seeded biological scaffold on surgical defect
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Limb Defects
Fasciocutaneous Flaps for Leg Defects
The purpose of this study is to determine the effects of fasciocutaneous flaps for leg defects.
- Trial name
- NCT01278836
- Testing
- fasciocutaneous flap
- Where
- Iran
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Smith Lemli Opitz Syndrome, CHILD Syndrome
Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism
Background: Smith-Lemli-Opitz Syndrome (SLOS) is a genetic disorder. It can cause birth defects and developmental delays. There is no cure for SLOS or other inherited diseases related to cholesterol production or storage.
- Conditions
- Smith Lemli Opitz Syndrome, CHILD Syndrome, Lathosterolosis, Desmosterolosis
- Trial name
- NCT05047354
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Complex Limb Bone Deformity, Limb Length Discrepancy
Multistage Additive Manufacturing for Complex Limb Bone Deformity Reconstruction
Complex deformities of the limb bones may involve abnormal angulation, limb or bone shortening, abnormal rotation and structural bone loss.
- Conditions
- Complex Limb Bone Deformity, Limb Length Discrepancy, Angular Deformity, Rotational Deformity
- Trial name
- MAP-BD (NCT07779278)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Bone Defect, Bone Tumor of Extremity
Clinical Efficacy Study of Magnesium-Containing Degradable Polymer Bone Repair Material for Bone-Defect Repair After Extremity Bone Tumor Resection
This is a single-center prospective randomized open-label non-inferiority clinical trial for adult patients with bone defects after extremity bone tumor resection.
- Conditions
- Bone Defect, Bone Tumor of Extremity, Bone-Like Tumor Lesion
- Trial name
- MAGBONE (NCT07794202)
- Testing
- Magnesium-containing degradable polymer bone repair material, Conventional non-magnesium bone repair material
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Yu Zhang, PhD
Periarticular Bone Defect, Proximal Humerus Fracture
Magnesium Alloy Scaffold With Controlled Degradation for Periarticular Bone Defects
This prospective, multi-center, randomized controlled clinical trial is designed to evaluate the effectiveness and safety of a biodegradable magnesium alloy scaffold with controlled degradation for the treatment of periarticular…
- Conditions
- Periarticular Bone Defect, Proximal Humerus Fracture, Distal Radius Fracture, Tibial Plateau Fracture
- Trial name
- MgScaf-PBD (NCT07906730)
- Testing
- Magnesium Alloy Scaffold, Calcium Sulfate Bone Graft Substitute
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Amputation; Traumatic, Limb, Postural; Defect
Comparison of Transtibial and Transfemoral Amputees' Posture Parameters
With the onset of prosthesis use following lower extremity amputations, body shows biomechanical changes according to the amputation level and consequently develops adaptation mechanisms both on the healthy and ampute side.
- Trial name
- NCT04456244
- Testing
- Evaluation of the static posture
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Orthopedic Disorder, Trauma Injury
X-BS Ortho Bone Graft Study
Randomised investigation of the osteoconductive performance and safety of CE-marked FDBS bone graft (GraftR3®), with contextual reference to CE-marked IBS (MBCP® Putty), in the filling of orthopaedic bone defects.
- Conditions
- Orthopedic Disorder, Trauma Injury, Extremity Injury
- Trial name
- NCT06326827
- Testing
- FDBS (GraftR3®), IBS (MBCP® Putty)
- Volunteers
- 200 people
- Sponsor
- Advanced Medical Solutions Ltd.
Syndromic Ichthyoses, CHILD Syndrome
Novel Treatment for Syndromic Ichthyoses
This is an open label-pilot study to assess the efficacy and safety of a novel cholesterol-lovastatin topical solution in children with rare syndromic ichthyoses.
- Conditions
- Syndromic Ichthyoses, CHILD Syndrome, Smith Lemli Opitz Syndrome, Conradi Syndrome
- Trial name
- NCT01110642
- Testing
- Lovastatin
- Sponsor
- Northwestern University
Muscle Hypotonia, Down Syndrome
Assessment of Hypotonia in Children With Down Syndrome
Hypotonia is a common trait in infants with Down syndrome, resulting in pathologies and delays in gaining basic motor skills. There are no screenings available to aid in early diagnosis, therefore, the purpose of this study is to…
- Conditions
- Muscle Hypotonia, Down Syndrome, Muscle, Floppy, CHILD Syndrome
- Trial name
- NCT05131542
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Murcia
CHILD Syndrome
Effects of Alexander Technique in Children With Upper Cross Syndrome.
This randomized clinical trial will involve 50 participants aged 13 to 16, recruited from Faisal Hospital Faisalabad and different schools nearby.
- Trial name
- NCT07248748
- Testing
- Alexander technique, Corrective exercises
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Amputation, Traumatic, Limb Defect
Assessing Force Feedback With the SoftHand Pro
The trial is designed to test the effectiveness of a force-feedback cuff in combination with a myoelectric prosthesis in conveying information on grasp strength to the user, as well as the user's preference regarding the feature.
- Trial name
- CUFF (NCT03412656)
- Testing
- SoftHand Pro with CUFF force feedback device
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Kristin Zhao, PhD
Bone Loss, Defect Limb
The Effectiveness in the Treatment of Long Bone Defect Using 3D-printed Implant
To evaluate the effectiveness of 3D-printed titanium alloy implants in the treatment of long bone defect in adults
- Trial name
- NCT04449211
- Testing
- Implantation
- Where
- Vietnam
- Volunteers
- 10 people
- Sponsor
- Cho Ray Hospital
Stroke, Sensory Defect
The Effect of ıntensified Sensory-based Therapy on Upper Extremity Functions and Activities of Daily Living
Sensory dysfunction following stroke is a common condition. The deficiency in the somatosensory system negatively affects the learning of new motor skills by preventing feedback from the sensory system, and it can also cause…
- Trial name
- NCT05133219
- Testing
- Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kocaeli University
Fractures, Bone, Fractures, Closed
Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System
This is an open-label, prospective, observational, post-market, uncontrolled, multi-center study intended to evaluate the safety and clinical performance of the FITBONE Transport and Lengthening Nail when used according to the…
- Conditions
- Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur
- Trial name
- NCT06400732
- Testing
- Fitbone Transport and Lengthening System
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- Orthofix Inc.
Lysosomal Storage Disease, Cholesterol Metabolism
Study of Inborn Errors of Cholesterol Synthesis and Related Disorders
This study will investigate the cause and medical problems associated with a group of genetic disorders known as inborn errors of cholesterol synthesis, in which the body does not produce cholesterol.
- Trial name
- NCT00046202
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Chronic (> 2 Weeks) Critical Ischemia With Skin Defect in Lower Limbs
Viennese Registry on Patients With Chronic Critical Limb Ischemia
The rationale of this study is to establish a registry to detect and follow patients with CLI treated in Vienna. The Vienna CLI registry is meant to document the incidence, prevalence, and actual outcome of CLI patients in a real…
- Trial name
- NCT01233141
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Sensation Disorders, Sensation, Phantom
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and…
- Conditions
- Sensation Disorders, Sensation, Phantom, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06094257
- Testing
- Sensory testing
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Child Syndrome
Study of Metabolic Modifications in Children With Noonan Syndrome
Noonan syndrome (NS) is a rare genetic disease (incidence 1/2500 live births) characterized by the association of craniofacial manifestations, cardiopathies, short stature, and tumor predisposition.
- Trial name
- MetabNoonan (NCT02383316)
- Testing
- Oral Glucose tolerance test
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse