Clinical trials: Defects
Visual Field Defect, Peripheral, Stroke
Improving Visual Field Deficits With Noninvasive Brain Stimulation
This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision…
- Conditions
- Visual Field Defect, Peripheral, Stroke, Visual Impairment, Hemianopsia
- Trial name
- NCT05085210
- Testing
- transcranial random noise stimulation (tRNS), Computer Based Visual Training, Virtual Reality Based Visual Training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Beth Israel Deaconess Medical Center
Congenital Heart Defects, Cardiac Surgery
Central Venous Saturation (ScvO2) Monitoring in Pediatric Patients Undergoing Cardiac Surgery
Children (ages 0-12) that have heart surgery are often at a high risk of developing complications and have to be continuously monitored.
- Trial name
- NCT00883922
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, Los Angeles
Patent Foramen Ovale
Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemia Attack or Paradoxical Embolism
The primary objective of this study is to demonstrate the safety of the PFX Closure System when utilized for patients with patent foramen ovale (PFO) suffering from cryptogenic stroke, transient ischemic attacks or paradoxical…
- Trial name
- NCT00196027
- Testing
- PFX Closure System
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cierra
Congenital Cataract
Morphologic and Biometric Characteristics of Preexisting Posterior Capsule Defects in Congenital Cataracts During the First Year of Life
Few descriptive studies have focused on the anatomical parameters in patients with preexisting PCDs. The characteristics of cataract morphology and anatomical parameters in these patients remained unclear, when compared with CC…
- Trial name
- NCT03342794
- Testing
- cataract surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Patent Ductus Arteriosus
Post Marketing Clinical Follow Up Study to Evaluate Efficacy and Safety of the Occlutech PDA Occluder in Patients With Patent Ductus Arteriosus Defects
This retrospective and prospective, multicenter, international post marketing follow up study evaluates the safety and efficacy of the Occlutech® PDA Occluder, delivered using the Occlutech Occlusions Pusher (OOP), in subjects…
- Trial name
- NCT05264753
- Testing
- Occlutech® PDA Occluder
- Where
- 15 sites in Canada, France and 7 more
- Volunteers
- 255 people
- Sponsor
- Occlutech International AB
Implant Site Pocket Infection
Regenerative Surgical Treatment of Peri-implant Defects
Does submerged healing of implants improve clinical and radiologic outcomes for the treatment of peri-implantitis? A number of recent systematic reviews have shown that the prevalence of periimplantitisin the population is high.
- Trial name
- NCT04440241
- Testing
- regenerative treatment periimplantitis
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Growth Hormone Deficiency
Use of miRNAs in Growth Hormone Deficiency (GHD)
This study aims at improving knowledge about the diagnosis of growth hormone deficiency (GHD) and treatment with growth hormone (GH), with the goal of providing information on the presence of new biomarkers, such as miRNAs, for…
- Trial name
- GH-miRNA2 (NCT06455956)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of Parma
Congenital Heart Disease
Cardiac Murmurs in Children: Predictive Value of Cardiac Markers
Heart murmurs are commonly discovered in young children during clinical encounters in general practice. Heart murmurs might signal a structural cardiac disease that need to be treated, such as atrial septal defect.
- Trial name
- CAMUS (NCT02746029)
- Testing
- Clinical examination
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- University Hospital, Akershus
Heart Septal Defects, Atrial
Bosentan for Mild Pulmonary Vascular Disease in Asd Patients.
Volume overload due to left-to-right shunting in patients with atrial septal defect type secundum causes pulmonary vascular disease over a long period of time.
- Trial name
- BOMPA (NCT01218607)
- Testing
- Bosentan
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Serious Games, Transition-age Youth
Aim 3: Pilot Study of a Serious Game to Promote Transition Readiness Skills
This study involves testing a new video game designed to support adolescents with congenital heart disease (CHD) in preparing to manage their health independently.
- Conditions
- Serious Games, Transition-age Youth, Transition to Adult Care, Congenital Heart Defect
- Trial name
- NCT07042334
- Testing
- Serious game for transition readiness
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Calprotectin, Cyanotic Heart Disease
Monitor Faecal Calprotectin Concentration in Infants With Heart Defects
Infants born with heart problems are at risk of developing gut disease due to reduced blood flow to the intestines which can result in poor weight gain, surgery and even death.
- Trial name
- NCT03255564
- Testing
- feacal calprotectin concentration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Congenital Heart Disease, Tetralogy of Fallot
Prognostic Value of NLR, TLR, and ALC in Predicting ToF Primary Repair Outcome
Tetralogy of Fallot (ToF) were cyanotic congenital heart disease with chronic hypoxia which increases the risk of exacerbated inflammatory response in ToF primary repair.
- Conditions
- Congenital Heart Disease, Tetralogy of Fallot, Neutrophil-lymphocyte Ratio, Absolute Lymphocyte Count
- Trial name
- NCT05976204
- Testing
- ToF primary repair
- Where
- Indonesia
- Volunteers
- 501 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Molar Incisor Hypomineralization
Clinical Performance of Restorations in Teeth Affected by Molar Incisor Hypomineralization
This study evaluated the clinical performances of a glass hybrid restoration and direct posterior micro-hybrid composite restorations with short fiber reinforced composite (SFRC) after Selective Caries Removal in restorations of…
- Trial name
- NCT07733804
- Testing
- Restoration with Short Fiber-Reinforced Composite and Micro-Hybrid Composite (EverX Flow + G-ænial Posterior), Restoration with Glass Hybrid Restorative Material (EQUIA Forte HT)
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Marmara University
Congenital Heart Disease
The Effect of 3D Heart Modelling on Family Quality of Life and Surgical Success
Introduction and Objective: In recent years, 3D (three-dimensional) modeling has been added to traditional and effective diagnostic methods such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Echocardiography.
- Trial name
- NCT05852106
- Testing
- Surgical Simulation with 3D Heart Model and Parental Education with "Congenital Heart Disease Parent Education Booklet" and tailored 3D Heart Modeling
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Yeditepe University
Cardiac Glycogenosis, Cardiomyopathy
ATR 1072 in Participants With PRKAG2 Syndrome
ATR 1072 is an investigational medicine being studied in adults with PRKAG2 Syndrome. This study will evaluate the safety of ATR 1072 and how the body processes the drug.
- Conditions
- Cardiac Glycogenosis, Cardiomyopathy, Hypertrophic, Wolff-Parkinson-White Syndrome
- Trial name
- NCT07738107
- Testing
- ATR 1072
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Atrium Therapeutics
Congenital Heart Disease, Cardiac Surgery
Perioperative Transfusion Strategies in Adult Congenital Heart Disease Patients Undergoing Cardiac Surgery
Due to better medical care, a growing number of patients with congenital heart disease reach adulthood. A large number of these patients needs a redo cardiac surgery.
- Conditions
- Congenital Heart Disease, Cardiac Surgery, Blood Transfusion, Morbidity, Multiple
- Trial name
- NCT04973514
- Testing
- Cardiac surgery in grown-up congenital heart disease patients
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Brugmann University Hospital
Pediatric Ventricular Septal Defects
Hybrid Closure of Congenital Heart Disease
Ventricular septal defect (VSD) is one of the most common pediatric congenital malformations. In recent years, in view of the rapid rise of transthoracic minimally invasive hybrid closure for pediatric VSD in the clinical…
- Trial name
- NCT02794584
- Testing
- sufentanil anesthesia, Hybrid closure, Control
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Hemifacial Microsomia, Mucormycosis
Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.
This clinical study aims to evaluate the effectiveness of patient-specific 3D-printed titanium facial implants in the reconstruction and aesthetic correction of facial defects.
- Conditions
- Hemifacial Microsomia, Mucormycosis, Oral Squamous Cell Carcinoma, Microgenia
- Trial name
- 3DFACE (NCT07654647)
- Testing
- Patient-specific titanium implants for facial reconstruction
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Latakia University
Congenital Heart Disease
Perioperative Outcome of Congenital Heart Disease Surgery in Childhood
Congenital heart disease is the most common congenital malformation in the world with high morbidity and mortality. However, there is no data to assess the perioperative outcome of congenital heart disease surgery among Chinese…
- Trial name
- NCT04093011
- Testing
- Congenital Heart Disease Surgery
- Where
- China
- Volunteers
- 6,500 people
- Sponsor
- Nanjing Medical University
Solid Cancers, BRCA Mutation
A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway
The primary objective of the study is to evaluate the safety, tolerability, PK, PD, and prilimary efficacy of a PARG inhibitor DAT-2645 in patients with advanced/metastatic solid tumors harboring BRCA1/2 loss of function…
- Conditions
- Solid Cancers, BRCA Mutation, HRD Cancer, Breast Cancer
- Trial name
- NCT06614751
- Testing
- DAT-2645 tablet
- Where
- 2 sites in China
- Volunteers
- 112 people
- Sponsor
- Danatlas Pharmaceuticals Co., Ltd
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