Clinical trials: Deglutition
GERD
Canadian, Multi-Centre Study of Symptom Burden and Clinical Management in Subjects With GERD
This is a cross-sectional study of symptom burden and clinical management. A subset of patients who have attended the Primary Care (PC) office with reflux symptoms during a retrospective period of 4 months (Index Visit) are…
- Trial name
- RANGE (NCT00634023)
- Where
- 15 sites in Canada
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Non-erosive Reflux Disease, Reflux Disease, Gastro-Esophageal
Evaluation of the Efficacy and Safety of Eolo in Patients With NERD
Background: Non-erosive reflux disease (NERD) is a prevalent subtype of gastroesophageal reflux disease (GERD), often inadequately managed with proton pump inhibitors (PPIs) alone.
- Conditions
- Non-erosive Reflux Disease, Reflux Disease, Gastro-Esophageal, Nutraceutical
- Trial name
- NCT07041060
- Testing
- EOLO, PPI (proton pump inhibitor), Group C: Eolo
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bologna
Laryngopharyngeal Reflux
Comparison of Voice Therapy and Antireflex Therapy in LPR
This study will be a prospective, randomized, unblinded but controlled trial. Patients presenting to the Otolaryngology clinic who are diagnosed with laryngopharyngeal reflux disorder related dysphonia and meet inclusion criteria…
- Trial name
- NCT02530879
- Testing
- Omeprazole, Lansoprazole, Esomeprazole, Rantidine, Voice therapy, Combination of anti-reflux medication and voice therapy
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Temple University
Head and Neck Cancer, Dysphagia
Assessment of (Chemo)RT-related Dysphagia in HNC Patients Based on Cough-related Acoustic Features
To develop this objective and easily implementable assessment method of coughing based on acoustic features of voluntary and reflex coughs, there is a primary need in identifying and comparing acoustic cough features in healthy…
- Trial name
- NCT05865756
- Testing
- Acoustic cough features analysis
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Jules Bordet Institute
Gastroesophageal Reflux
A Study of Cisapride in Patients With Symptomatic Gastro-Oesophageal Reflux Disease
The purpose of this study is to compare the efficacy and tolerability of cisapride with placebo in infants and children with gastro-oesophageal reflux disease (GORD).
- Trial name
- NCT01281553
- Testing
- Cisapride
- Volunteers
- 6 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Achalasia
Peroral Endoscopic Myotomy for the Treatment of Achalasia
There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019 \& a prospective chart review will be performed for patients who will undergo endoscopic procedures and…
- Trial name
- NCT04640753
- Testing
- Endoscopic procedure for achalasia
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Methodist Health System
Dysphagia
Neuromuscular Electrical Stimulation (NMES) for Dysphagia in Neonates
The purpose of this study is to evaluate if the use of Neuromuscular Electrical Stimulation (NMES) will provide a more efficient method of treating neonates with dysfunctional oral feeding such as dysphagia.
- Trial name
- NCT02007759
- Testing
- VitalStim
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Sanford Health
Gastroesophageal Reflux
Open, Randomised, Multi-center Study of on Demand Versus Continuous Esomeprazole Treatment in Patient With GERD
The purpose of this study is to compare on demand with continuous treatment of endoscopy negative subjects with gastroesophageal reflux disease (GERD), with esomeprazole 20-mg once daily, with regards to willingness to continue…
- Trial name
- NEED (NCT02670642)
- Testing
- Esomeprazole
- Where
- 60 sites in Austria, France and 3 more
- Volunteers
- 877 people
- Sponsor
- AstraZeneca
Dysphagia, Dysphagia, Swallowing Function, Diet Modification, Dysphagia Diet, Diet Standardization
GUSS-ICU Safe Nutrition Program After Extubation in ICU Patients
The aim of this study is to evaluate the effects of using the GUSS-ICU Safe Nutrition Program after extubation in Intensive Care Unit patients.
- Trial name
- NCT07195383
- Testing
- Nutrion plan based on GUSS-ICU scale
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Istanbul University - Cerrahpasa
Cough, Gastroesophageal Reflux
Exhaled Breath Condensate pH in Patients With Cough Caused by Gastroesophageal Reflux
Cough is the most common complaint for which patients seek medical attention in the United States, accounting for approximately 1 billion dollars in health care expenses annually.
- Trial name
- NCT00451841
- Testing
- RTube Exhaled Breath Condensate Collection System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Massachusetts, Worcester
Stroke ( 3 Months After Onset), Dysphagia
Dysphagia Management for Caregivers of Stroke Patients
This randomized controlled experimental study was conducted to evaluate the effects of dysphagia management training provided to caregivers of stroke patients receiving home care.
- Conditions
- Stroke ( 3 Months After Onset), Dysphagia, Palliative Care, Caregiver
- Trial name
- NCT07181629
- Testing
- Control, Dysphagia Management Education
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Uludag University
Gastroesophageal Reflux Disease
Study to Evaluate the Influence of Tegoprazan on the Pharmacokinetics of Proguanil in Healthy Volunteers
The aim of this study is to evaluate the influence of tegoprazan on the pharmacokinetics of proguanil in healthy volunteers.
- Trial name
- NCT04568772
- Testing
- Atovaquone / Proguanil 250/100 mg, Tegoprazan 50 mg, Esomeprazole 40 mg
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Seoul National University Hospital
Deglutition Disorders
Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging
Oropharyngeal dysphagia (OD) is the most frequent digestive disorder in older people (>70 years) and has been recently recognized as a geriatric syndrome.
- Trial name
- NCT03050957
- Testing
- menthol
- Volunteers
- 38 people
- Sponsor
- Hospital de Mataró
Esophageal Motility Disorders
U-POEM vs CO2-POEM
Multicenter randomized trial comparing post-procedural pain intensity after Per-Oral endoscopic myotomy (POEM) between two types of standard of care insufflation methods (CO2 vs Underwater).
- Trial name
- U-POEM (NCT06918730)
- Testing
- U-POEM, CO2-POEM
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- AdventHealth
Laryngopharyngeal Reflux
Efficacy of Reza Band for the Treatment of Laryngopharyngeal Reflux
We hypothesize that tissue and salivary pepsin will resolve after 12 weeks use of Reza Band, but not following standard of care alone.
- Trial name
- NCT03463395
- Testing
- Reza band
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Deglutition Disorder, High Risk Pregnancy
Study of Fetal Swallowing
This study will establish a database of fetal movements associated with feeding. It will use information obtained from standard fetal ultrasound procedures to identify and measure the growth of the baby's face, lips, tongue, jaw…
- Trial name
- NCT00004566
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Dysphagia, Stroke
Fostering Eating After Stroke With Transcranial Direct Current Stimulation
Swallowing difficulties are common after a stroke and can lead to serious complications like pneumonia and malnutrition. Unfortunately, there are no effective treatment for improving swallowing in stroke patients.
- Trial name
- FEASt (NCT01919112)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Dysphagia
Simple Swallowing Training Program on Older Individuals in the Community
The goal of this clinical trial is to explore the effects of a simple swallowing training program on the swallowing function, airway protection, nutritional risk, daily choking, quality of life, and mental health of elderly…
- Trial name
- SSTP1year (NCT07373028)
- Testing
- Simple swallowing training program, Active non-swallowing training
- Where
- 2 sites in China
- Volunteers
- 474 people
- Sponsor
- Zeng Changhao
Cancer of Head and Neck
Swallowing Rehabilitation in Patients With Head and Neck Cancer Receiving Radiotherapy
Head and neck cancer has a negative impact in swallowing function and quality of life. Rehabilitation has proven its usefulness after radiation therapy (RT), but some studies suggest that interventions should be initiated prior…
- Trial name
- ReDyOR (NCT02900911)
- Testing
- Early rehabilitation, Late rehabilitation
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Parc de Salut Mar
Systemic Sclerosis (SSc), GERD (Gastroesophageal Reflux Disease)
PPI Refractory - GERD Mechanisms in Systemic Sclerosis
The goal of this observational study is to learn about the mechanisms of gastroesophageal reflux disease (GERD) in patients with systemic sclerosis (SSc) who continue to experience reflux symptoms despite treatment with proton…
- Trial name
- NCT07022912
- Testing
- educational healthcare intervention, Objective assessment of GI motility, Evaluation of GERD severity
- Volunteers
- 147 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute