Clinical trials: Delivery Systems
Asthma, Wheezing
Pulmonary Epithelium, Immunology and Development of Asthma: Breathing Together
The investigators want to know why some babies wheeze and some of these go on to develop asthma. The investigators are going to find out if babies who develop wheeze and asthma have abnormal airway lining cells (taken from the…
- Trial name
- NCT04063631
- Where
- United Kingdom
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cancer
Pilot Study of App-delivered Sleep Coaching Among Cancer Survivors and Their Partners
The proposed study will test the feasibility and acceptability of enrolling and retaining cancer survivors and their bedroom partners in a study evaluating digitally delivered behavioral sleep interventions.
- Trial name
- ACCESS (NCT06938802)
- Testing
- Sleep coaching, Sleep education
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Schizophrenia, Bipolar Disorder
Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery
Adults with serious mental illness (SMI) are disproportionately affected by medical comorbidity, earlier onset of disease, and 10 to 25 years reduced life expectancy compared to the general population.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Recurrent, Obesity
- Trial name
- NCT04481737
- Testing
- Peer-delivered and Technology Support Integrated Illness Management and Recovery, Peer support
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Analgesia
Comparison of Patients' Postpartum Recovery Using ObsQoR-10 Score in Pregnant Women in Vaginal Delivery With and Without Neuraxial Labor Analgesia
The aim of this study was to compare the postpartum recovery of pregnant women who had vaginal delivery with and without neuraxial labor analgesia using the ObsQoR-10 scoring system.
- Trial name
- NCT06325475
- Testing
- labor with neuraxial labor analgesia, labour without noroaxial labor analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Heat Effect
Effect of Heat on Oxybutynin Release and Absorption From Oxybutynin Products
This research study is intended to determine the effect of heat and occlusion on oxybutynin products.
- Trial name
- NCT03205605
- Testing
- oxybutynin
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cerebral Palsy, Prematurity
Best Practices Fo Early Diagnosis of Cerebral Palsy
In this research, the investigators are using an implementation science approach to enhance the uptake of a clinical practice guideline for earlier diagnosis of cerebral palsy (i.e.
- Trial name
- CP (NCT06537622)
- Testing
- Implementation group, Standard of care
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Metabolic Diseases, Neurological and Mental Health Conditions
Growing Up in Singapore Towards Healthy Outcomes
This study aims to examine the role of genetic and epigenetic factors, maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of…
- Conditions
- Metabolic Diseases, Neurological and Mental Health Conditions, Genetic Predisposition, Skin Condition
- Trial name
- GUSTO (NCT01174875)
- Where
- Singapore
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Irritable Bowel Syndrome, GI Disorders
GUT LINK: A Study of a Care Pathway Across Primary and GI Specialty Care
It can be challenging for Primary Healthcare Providers (PHCPs) to differentiate between IBS and more serious illnesses involving the GI tract, such as Crohn's disease, ulcerative colitis, or cancer.
- Trial name
- NCT05725954
- Testing
- GUT LINK SmartPath
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Michael Stewart
Smoking Cessation, Oxidative Stress
ESTxENDS Trial-Substudy on Oxidative Stress Induced by Electronic Nicotine Delivery Systems (ENDS) Measured in Urine
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Oxidative stress outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT03612375)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- University of Bern
Smoking Cessation, Electronic Cigarette Use
Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan
Smoking is prevalent in Pakistan, and a large proportion of the adult population smokes cigarettes or uses other forms of tobacco.
- Trial name
- NCT06063421
- Testing
- Electronic Cigarette (EC), Nicotine Replacement Therapy
- Where
- Pakistan
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Strategic Health Research Limited
Malaria, Human Immunodeficiency Virus
Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE-BC2)
This is a double-blinded, randomized controlled trial of 200 HIV-infected pregnant women living in Tororo, Uganda, an area of high malaria transmission.
- Trial name
- NCT02282293
- Testing
- Monthly dihydroartemisinin-piperaquine (DP) + daily trimethoprim/sulfamethoxazole (TS)
- Where
- Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Safety and Tolerability Study of Transscleral Iontophoresis by the EyeGate® II Drug Delivery Device System
The purpose of this study is to evaluate the safety and tolerability of a single iontophoretic dose of buffered solution administered through the EyeGate® II Drug Delivery System in healthy adult human volunteers.
- Trial name
- NCT00698425
- Testing
- EyeGate II® Drug Delivery System, Citrate buffer
- Where
- India
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Pain, Postoperative, Anesthesia, Local
Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery
This study will investigate the effect of three types of wound infiltration on post Cesarean opioid analgesia consumption when used in conjunction with an opioid free postoperative analgesia pathway.
- Conditions
- Pain, Postoperative, Anesthesia, Local, Opioid Use
- Trial name
- NCT03545516
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Richmond University Medical Center
Cigarette Smoker, Current Smoker
Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers
This randomized pilot clinical trial studies nicotine delivery from novel non-tobacco electronic system (ENDS) in smokers. Studying the levels of nicotine delivered by various types and brands of ENDS to the bloodstream, and…
- Conditions
- Cigarette Smoker, Current Smoker, Healthy Subject
- Trial name
- ENDS (NCT02575885)
- Testing
- Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
E-Cig Use
Psychometric Properties of the Chinese Version of Penn State [Electronic] Cigarette Dependence Index
The purpose of this study is to realize the first evaluation of the psychometric characteristics of the Chinese version of the the Penn State University Electronic Cigarette Dependence Index Scale.
- Trial name
- NCT05477888
- Testing
- Questionnaires set
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Parturient Who Underwent Epidural Anesthesia During Which an Unintentional Dural Punctur Occurred, Parturient Who Develop a Postdural Puncture Headache
Chronic Headache and Chronic Backache Following Unintentional Dural Puncture at Delivery Room.
he study is a telephone questionnaire. The study will include 400 women, 100 in each group. OBJECTIVE: To investigate the prevalence of chronic and chronic back pain following PDPH accidental dural puncture during epidyral…
- Conditions
- Parturient Who Underwent Epidural Anesthesia During Which an Unintentional Dural Punctur Occurred, Parturient Who Develop a Postdural Puncture Headache, Parturient Who Gave Informed Consent to Participation in the Study
- Trial name
- NCT03908424
- Testing
- Epidural Blood patch.
- Where
- Israel
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Hearing Disorders
Hearing Problems in Children of Rheumatic Diseased Mothers
Evaluation of the hearing functions of children born to rheumatic diseased mothers who received gestational antimalarial drugs versus those didn't receive gestational antimalarials drugs compared with normal healthy children.
- Trial name
- NCT03666910
- Testing
- Audiometer
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Smoking Cessation, Cardiovascular Diseases
The ESTxENDS Trial- Substudy on the Metabolic Effects of Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Metabolic outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT03612336)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- University of Bern
HIV Infection, Young Adult
Cohort of Young Adults Infected With HIV Since Birth or During Childhood
Background: With the improvement of the prognosis for HIV-infected infants, thanks to the availability of antiretroviral therapies, young adults infected with HIV since birth are becoming an emerging group among the HIV-infected…
- Trial name
- CO19 COVERTE (NCT01269632)
- Testing
- blood sampling, specific biological exams and biobank and self administered questionnaires
- Where
- France
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Hepatitis B, Immunization; Infection
Hepatitis B Birth Dose for Newborns
With 2.5% prevalence in general population, Pakistan is an intermediate endemicity country for hepatitis B. However, wide disparity exists across the country as disease prevalence in general population soars as high as 14% in…
- Trial name
- HepB-BirD (NCT04870021)
- Testing
- recombinant hepatitis B vaccine ENGERIX 10 micrograms (µ gm),, Short text messages and calls to parents for compliance to routine immunization schedule
- Where
- Pakistan
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Quaid-e-Azam University