Clinical trials: Delivery Systems
Diphtheria, Hepatitis B
Pilot Study Freeze and Transport Immune Cells
To evaluate and standardize umbilical cord specimen collection and laboratory procedures to evaluate cellular and serological immune responses in neonates and young infants
- Conditions
- Diphtheria, Hepatitis B, Pertussis, Poliomyelitis
- Trial name
- NCT00138268
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hypocalcemia, Hypercalcemia
Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome
Parathyroid hormone (PTH) gland calcium sensing receptor (CASR) regulates PTH secretion. CASR is also expressed in nephron thick ascending limb (TAL).
- Trial name
- NCT01021280
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Smoking Cessation, Toxicity
The ESTxENDS Trial- Substudy on the Effect on Toxins From Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Toxins outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT03612544)
- Testing
- ENDS (Vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- University of Bern
HIV Infections
Young Men's Health Project Targeting HIV Risk Reduction and Substance Abuse
YMHP is a counseling intervention program for which the goals are to better understand HIV-prevention focused self-management behaviors among HIV-negative YMSM, and to study the implementation of YMHP to improve portability and…
- Trial name
- YMHP (NCT03577301)
- Testing
- Clinic-based Delivery, Remote Delivery, Multi-modal Delivery
- Where
- 3 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Florida State University
Healthy Volunteer
Study to Compare Active Tymbion Iontophoresis to Sham Tymbion Iontophoresis for Anesthesia of the Tympanic Membrane
A prospective, multicenter study to determine if active Tymbion iontophoresis is superior to sham Tymbion iontophoresis in providing anesthesia to the tympanic membrane (TM).
- Trial name
- ADEPT (NCT03119181)
- Testing
- Tymbion Lidocaine/epinephrine solution, Device: Iontophoresis System (IPS) with Drug: Tymbion lidocaine/epinephrine solution
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tusker Medical
Coenzyme Q10 Pharmacokinetics
Pharmacokinetics of Different CoQ10 Formulations
The objective of this trial is to compare the bioavailability (AUC, Tmax, and Cmax) of different Coenzyme Q10 preparations in healthy adults.
- Trial name
- NCT06151171
- Testing
- CoQ10
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Factors Group of Nutritional Companies Inc.
Irritable Bowel Syndrome, Abdominal Pain
Comparing a 182mg Colon-targeted-delivery Peppermint Oil Capsule (Tempocol-ColoPulse®) and a 182mg Enteric-coated Peppermint Oil Capsule (Tempocol®), a Pharmacokinetic Study
This is a pilot study to compare the relative bioavailability between two peppermint oil formulations, namely a ileocolonic release peppermint oil and an small intestinal release peppermint oil (Tempocol®).
- Conditions
- Irritable Bowel Syndrome, Abdominal Pain, Colonic Diseases, Visceral Pain
- Trial name
- NCT02291445
- Testing
- Menthae piperitae aetheroleum/peppermint oil (enteric coated capsule), Menthae piperitae aetheroleum/peppermint oil (colon-targeted-delivery capsule)
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Smoking Cessation, Micronuclei
ESTxENDS Trial: MN Substudy - Micronuclei in Buccal Epithelium, a Surrogate Measure of Future Cancer Risk, Induced by Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Micronuclei in buccal epithelial outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT04244773)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- University of Bern
Anesthesia, Analgesia
The Efficacy and Safety of S-ketamine in Elective Cesarean Section
During the past years, a large number of clinical trials have investigated the use of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist racemic ketamine as an adjunct to local anaesthetics, opioids, or other…
- Conditions
- Anesthesia, Analgesia, Depression, Cesarean Section
- Trial name
- ES-CS (NCT04657107)
- Testing
- S-ketamine, normal saline
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Diabetes Mellitus, Type 1
Best Practice Advisories to Reduce Inequities in Technology Use for People With Type 1 Diabetes
The overall goal of the study is to create a standardized, stakeholder-informed system within EMRs, that will enable an equitable and regular prescription and documentation of advanced diabetes technologies.
- Trial name
- NCT06931275
- Testing
- EMR-based BPA model
- Where
- 2 sites in United States
- Volunteers
- 1,178 people, healthy volunteers welcome
- Sponsor
- T1D Exchange, United States
Necrotizing Enterocolitis
Necrotizing Enterocolitis (Nec) and B. Lactis in Premature Babies
The purpose of the trial is to demonstrate the effect of B. lactis in reducing the incidence of Necrotizing Enterocolitis (NEC) compared to placebo in preterm infants.
- Trial name
- NCT00977912
- Testing
- Probiotic supplementation
- Where
- 3 sites in South Africa
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Insomnia
Internet Delivered Self-Help CBT for Insomnia
The object of this study is to determine variables associated with therapy-success of a cognitive behavioral self help intervention for insomnia.
- Trial name
- NCT01224912
- Testing
- Cognitive Behavioral Treatment
- Where
- Netherlands
- Volunteers
- 479 people, healthy volunteers welcome
- Sponsor
- Utrecht University
Diabetes Mellitus Type 2 With Hyperglycemia
Pathways for Health Equity Quality Improvement Strategy
The PATHWAYS for Health Equity research program builds on the 5-year FORGE AHEAD Indigenous diabetes quality improvement research program (2013 - 2017).
- Trial name
- NCT03315728
- Testing
- Quality Improvement Strategy
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Food Insecurity, Diabetes Mellitus, Type 2
Delivering Health: Addressing Diabetes and Food Insecurity
The goal of this study was to develop, implement, and evaluate the effectiveness of an intervention to use home-delivery of Type 2 diabetes (T2D)-appropriate food boxes with plain language adapted education materials to improve…
- Trial name
- NCT04831216
- Testing
- Type 2 Diabetes Appropriate Food Boxes + Diabetes Education
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Halitosis, Oral Malodor
Prevention of Oral Malodor With an Oral Sticker Containing Herbal Formula
the use of a herbal formulation containing sage, echinacea,lavender and mastic gum would prevent oral malodor if delivered in an appropriate delivery system to enable slow release of the active ingredients.
- Conditions
- Halitosis, Oral Malodor, Bad Breath
- Trial name
- NCT00250289
- Testing
- a mucosal sticker with herbal formula
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Hepatitis B
Immunogenicity and Safety of Primary and Booster Vaccination With DTPa-HBV-IPV/Hib Vaccine
This study will assess the immunogenicity, safety and reactogenicity of GSK Biological's DTPa-HBV-IPV/ Hib vaccine as compared to GSK's DTPa-IPV/Hib vaccine co-administered with HBV according to a three-dose immunisation course…
- Trial name
- NCT00880477
- Testing
- DTPa-HBV-IPV/Hib vaccine, DTPa-IPV/Hib vaccine, EngerixTM-B
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infection, Sexually Transmitted Infections
Improving HIV Prevention Among Heterosexual Men Seeking STI Services in Malawi
To evaluate the potential benefit(s), acceptability, and associated costs of a systems navigator-delivered HIV prevention intervention in promoting and supporting persistent use of evidence-based HIV pre-exposure prophylaxis…
- Conditions
- HIV Infection, Sexually Transmitted Infections, Pre-exposure Prophylaxis, Systems Navigation
- Trial name
- NJIRA (NCT06200545)
- Testing
- PrEP eligibility assessment, Rapid HIV antibody testing prior to provision and/or refill of PrEP, PrEP follow-up with a PrEP nurse in accordance with contemporary PrEP guidelines
- Where
- Malawi
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- HIV Prevention Trials Network
Healthy Participants
A Study to Investigate the Exposure of Budesonide, Glycopyrronium, and Formoterol (BGF) Delivered by Hydrofluoroolefin (HFO) Propellant Metered Dose Inhaler (MDI) Compared to a Hydrofluoroalkane (HFA) Propellant MDI in Healthy Adults
This study aims to assess the bioequivalence of the total systemic exposure and safety of budesonide, glycopyrronium, and formoterol (160/14.4/4.8 µg/actuation) when administered as BGF MDI HFO compared with BGF MDI HFA in…
- Trial name
- NCT06723756
- Testing
- Treatment A: BGF MDI HFO, Treatment B: BGF MDI HFA
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hiv
Pharmacy-based PrEP Delivery in Kenya
A cluster-randomized control trial (cRCT) testing different cost-sharing models for the delivery of HIV pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) services at private pharmacies in Kenya.
- Trial name
- NCT05842122
- Testing
- Client-sustained delivery of pharmacy PrEP/PEP, Implementor-sustained delivery of pharmacy PrEP/PEP, Counselor-supported delivery of pharmacy PrEP/PEP
- Where
- 2 sites in Kenya
- Volunteers
- 5,808 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Instrumental Delivery, NEC, Affecting Fetus or Newborn
PROPENSITY-ID: Sonographic and Clinical Assessment of Head Position Prior to Instrumental Delivery and Labour Outcomes
Instrumental delivery is performed in 3-15% of all births (1). Successful instrumental delivery avoids need for cesarean section with associated maternal surgical morbidity, risk from neonatal disimpaction and future pregnancy…
- Conditions
- Instrumental Delivery, NEC, Affecting Fetus or Newborn, Second Stage Cesarean Delivery, Occiput Position
- Trial name
- PROPENSITYID (NCT05557097)
- Testing
- Intrapartum sonography
- Where
- Italy
- Volunteers
- 2,282 people, healthy volunteers welcome
- Sponsor
- University of Parma