Clinical trials: Depigmentation Treatment, open to volunteers
Oculocutaneous Albinism (OCA)
Safety and Efficacy of a Single Suprachoroidal Injection of JWK010 Gene Therapy in Subjects With Oculocutaneous Albinism Type 1 (OCA1)
Oculocutaneous albinism (OCA) is the most common type of albinism. People with OCA have little or no pigment (melanin) in their eyes, skin, and hair.
- Trial name
- NCT07313618
- Testing
- JWK010 gene therapy
- Where
- China
- Volunteers
- 18 people
- Sponsor
- West China Hospital
Vitiligo, Child
Oral Tacrolimus vs Dexamethasone Micro-pulse Therapy in Pediatric Rapidly Progressing Vitiligo: A Multicenter RCT
This clinical study aims to compare the safety and effectiveness of two treatments-oral Tacrolimus capsules and Dexamethasone micro-pulse therapy-in children aged 4-12 years with rapidly progressing vitiligo.
- Conditions
- Vitiligo, Child, Progressive Disease
- Trial name
- NCT06900777
- Testing
- Tacrolimus, Dexamethasone
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Vitiligo
Topical Methotrexate with Fractional CO2 Laser in Treatment of Non Segmental Vitiligo
This prospective, within subject clinical trial aims to evaluate the efficacy of combining fractional CO2 laser with topical methotrexate versus topical methotrexate alone in treating non-segmental vitiligo.
- Trial name
- NCT06877455
- Testing
- Fractional CO2 laser assisted PDT
- Volunteers
- 50 people
- Sponsor
- Assiut University
Vitiligo
Autologous Non-cultured Epidermal Cell Suspension Transplantation in the Treatment of Vitiligo
To observe the long-term efficacy and safety of autologous non cultured epidermal cell suspension transplantation in the treatment of vitiligo, analyze the correlation between cell density, type, and postoperative efficacy and…
- Trial name
- NCT07187882
- Testing
- Autologous Non-cultured Epidermal Cell Suspension transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Vitiligo - Macular Depigmentation
Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"
This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo.
- Trial name
- NCT07548918
- Testing
- microneedling with minoxidil 5% and NBUVB, Microneedling with Minoxidil5%
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Vitiligo Vulgaris, Psoriasis
PALLAS Laser for Skin Diseases
The primary objective of this study is to get clinical experiences with the PALLAS laser in the treatment of skin conditions that respond well to UV light (vitiligo, psoriasis, alopecia areata, atopic dermatitis).
- Conditions
- Vitiligo Vulgaris, Psoriasis, Alopecia Areata, Atopic Dermatitis
- Trial name
- PALLAS-UV (NCT07250997)
- Testing
- UVB laser treatment
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Szeged University
Vitiligo
The Value of Adding Mini-oral Pulse Steroid Therapy in Preventing Peri-lesional Halo Post Non-cultured Epidermal Cell Suspension (NCES) in Cases With Stable Segmental and Non-acral Vitiligo.
The goal of this clinical trial is to learn if adding mini-oral pulse steroid therapy improves the results of non-cultured epidermal cell suspension (NCES) surgery in patients with stable vitiligo.
- Trial name
- NCT07472816
- Testing
- Non-cultured epidermal cell suspension (NCES) surgery, Oral mini pulse, Excimer Sessions
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Vitiligo, Mesenchymal Stem Cells
Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Vitiligo
This study evaluates whether exosomes derived from human umbilical cord mesenchymal stem cells (hUMSCs-Exo) are safe and effective for treating vitiligo in adults.
- Conditions
- Vitiligo, Mesenchymal Stem Cells, Exosomes
- Trial name
- hUMSCs-Exo-VIT (NCT07519031)
- Testing
- Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Intravenous Infusion, Oral Prednisone, Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Local Injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Xijing Hospital
Vitiligo
A Real-world Study on the Influencing Factors of Efficacy of Ruxolitinib Cream in Vitiligo
Vitiligo is a common chronic autoimmune skin disease that can occur on any part of the body and severely impacts patients' quality of life.
- Trial name
- NCT07153666
- Testing
- Ruxolitinib 1.5% Cream BID
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Peking University Third Hospital
GIST - Gastrointestinal Stromal Tumor, KIT Gene Mutation
Comparing Regorafenib Combined With Envafolimab to Physician's Choice in Patients With Metastatic Gastrointestinal Stromal Tumors Harboring KIT Exon 17 Mutations Refractory to Standard Treatment
Gastrointestinal stromal tumors (GISTs) are mostly driven by c-kit or PDGFRA mutations, and commonly occur in the stomach and small intestine.
- Trial name
- NCT07559864
- Testing
- physician-selected treatment, Regorafenib + Envafolimab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jian Li
Vitiligo, Generalized
Comparison of Efficacy and Safety Psoralen Combined With Ultraviolet A (PUVA) Vs Tofacitinib in the Treatment of Generalized Vitiligo.
This study aims to compare the efficacy and safety of PUVA versus Tofacitinib in the treatment of generalized vitiligo. Given the high prevalence of vitiligo in Pakistan and the significant psychosocial impact on patients…
- Trial name
- (PUVA) (NCT07055529)
- Testing
- Group A recieving PUVA therapy, Group B receiving Tablet Tofacitinib
- Where
- Pakistan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Depigmentation Treatment, Depigmentation
Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation
This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.
- Trial name
- Effect of Coe (NCT07677826)
- Testing
- surgical depigmentation, Coenzyme Q10, Vitamin C
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Upper Cross Syndrome, Spinal Alignment
Beyond Osteopathic Therapy: Functional Performance Following the Addition of Ujjayi Pranayama in College Students With Upper Cross Syndrome
This study aims to explore the relationship between spinal alignment and functional performance in individuals with upper cross syndrome following a combined breathing and manual therapy program.
- Conditions
- Upper Cross Syndrome, Spinal Alignment, Functional Performance
- Trial name
- NCT07786415
- Testing
- The experimental group will perform ujjayi pranayama and osteopathic manipulative tratment, control group will perform osteopathic manipulative treatment only
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Zaytoonah University of Jordan
Leukoderma
NCMT Technique and Jodhpur Technique and Excimer Laser in Treatment of Non Vitiligo Leucoderma
This study aims to compare the efficacy and safety of Melanocyte Keratinocyte Transplantation Procedure (MKTP) combined with 308-nm excimer laser versus Jodhpur technique combined with 308-nm excimer laser in the treatment of…
- Trial name
- NCT07662915
- Testing
- Melanocyte Keratinocyte Transplantation Procedure (MKTP), Jodhpur Technique, 308-nm Excimer Laser
- Volunteers
- 22 people
- Sponsor
- Al-Azhar University
Psoriasis, Atopic Dermatitis
LANDSCAPE: Demographics and Treatment Patterns of Patients With Immune-Mediated Inflammatory Skin Diseases in Italian Clinical Practice
This multicenter retrospective observational registry study will collect existing clinical data from Italian centers to describe epidemiology, treatment patterns, clinical evolution, safety, and comorbidities in patients aged 12…
- Conditions
- Psoriasis, Atopic Dermatitis, Vitiligo, Alopecia Areata
- Trial name
- LANDSCAPE (NCT07336641)
- Testing
- Conventional Systemic Therapies, Biologic Therapies
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- Fondazione ISIDE
Vitiligo - Macular Depigmentation, Tacrolimus
COMPARISON OF EFFICACY AND SAFETY OF NARROWBAND UVB WITH 0.1% TACROLIMUS VS NARROWBAND UVB WITH 0.005% CALCIPOTRIOL IN TREATMENT OF VITILIGO
Patient of stable and limited vitiligo less than 20% BSA will be recruited And evaluation of efficacy and safety of narrowband UVB with topical tacrolimus vs narrowband UVB and calcipotriol will be assessed
- Trial name
- NB-UVB (NCT06880042)
- Testing
- Tacrolimus, Calcipotriol
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr ayesha wahid
Upper Crossed Syndrome
Effect of Kendall Versus McKenzie Exercises in Patients With Upper Crossed Syndrome
The study was conducted to evaluate effects of Kendall versus McKenzie exercise on pain ,functional disability and craniovertebral angle in upper cross syndrome over the course of 6 week
- Trial name
- NCT07921030
- Testing
- Kendall Excercise, Mckenzie Excercise, Standard Physical Therapy
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Gingival Pigmentation, Depigmentation
Gingival Hyperpigmentation Treatment
It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel
- Conditions
- Gingival Pigmentation, Depigmentation, Vitamin C, Glutathione
- Trial name
- NCT07595705
- Testing
- Vitamin c and glutathione, Surgical depigmentation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vitiligo Vulgaris
Mitochondrial Network Modulation Approach Using Hyperbaric Oxygen (HBO) Therapy and Nb-UVB for Treating Vitiligo
Vitiligo affects approximately 1 to 2% of the global population and significantly impacts people's quality of life. Achieving the best treatment outcomes for vitiligo involves addressing the autoimmune inflammatory response for…
- Trial name
- MitOxyVit (NCT07557693)
- Testing
- OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vitiligo
Comparative Efficacy of hUCMSC-Secretome Delivered Via Microneedling and Intradermal Microinjection as Adjuvant Therapy to NB-UVB in Nonsegmental Vitiligo: A Quasi-Experimental Study
The goal of this clinical trial is to analyze the effectiveness of SM-hUCMSC secretome administered via microneedling and intradermal microinjection as adjuvant therapy to NB-UVB, compared with NB-UVB alone, in terms of…
- Trial name
- Vitiligo (NCT07509242)
- Testing
- NB-UVB combined with microneedling and topical 10% secretome, receives NB-UVB combined with intradermal secretome injection, NB-UVB alone
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Yohanes Firmansyah, dr, MH, MM