Clinical trials: Depression NOS
Treatment Resistant Depression
Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine
This study aims to assess the efficacy and safety of intranasal esketamine as maintenance antidepressant therapy in patients who have demonstrated clinical improvement with off-label intravenous racemic ketamine for…
- Trial name
- NCT04856124
- Testing
- Intranasal esketamine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Psych Atlanta
Covid19, Depression
Depression and Anxiety in Long Term Coronavirus Disease COVID-19
Background : Depression and Anxiety are linked to COVID (Coronavirus Disease)-19 long-term impact through several mechanisms. The possible way is the alteration of neurotransmitter regulation from the interaction of severe acute…
- Conditions
- Covid19, Depression, Anxiety
- Trial name
- DALT-COV (NCT04893668)
- Testing
- Depression, Anxiety
- Where
- Indonesia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Restless Legs Syndrome, Sleep Quality
Restless Legs Syndrome and Sleep Quality in Pes Planus
Pes planus, also known as flatfoot, is a common foot deformity that can affect the biomechanics of the lower limbs. However, its relationship with neurological conditions has not been studied extensively.
- Conditions
- Restless Legs Syndrome, Sleep Quality, Pain, Quality of Life
- Trial name
- FLAT-RLS (NCT07117591)
- Where
- Turkey (Türkiye)
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Bozok University
Mental Health (Depression), Mental Health and General Well-being
Thrive at Home: A Virtual Reality Social Intervention for Older Adults
The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care.
- Conditions
- Mental Health (Depression), Mental Health and General Well-being, Loneliness, Well Being
- Trial name
- Thrive at Home (NCT07835568)
- Testing
- Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Cognitive Assessment, Working Memory
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor.
- Conditions
- Cognitive Assessment, Working Memory, Executive Function (Cognition), Sustained Attention
- Trial name
- NCT07319117
- Testing
- Skoshify 'Think Tank' Formulation
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Depression, Anxiety
Cross-Cultural Differences in the Network Structure of Social Anxiety and Body Dysmorphic Symptoms
This study will examine cross-cultural differences in the network structure of social anxiety and body dysmorphic symptoms across Germany, the United States, and Japan.
- Conditions
- Depression, Anxiety, Body Dysmorphic Disorders
- Trial name
- NCT06962917
- Testing
- Cross sectional study
- Where
- Germany
- Volunteers
- 1,523 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Anxiety
Feasibility Study of a Music and Social Support Intervention for Postnatal Mothers/Infants
This research study aims to assess the feasibility of conducting a full scale trial of Mamas in Harmony, a group music and social support class delivered by a professional musician for mothers and their babies.
- Trial name
- NCT05930990
- Testing
- Mamas in Harmony
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Depression
Efficacy of Spanish or English Language Versions of Mindfulness Meditation on Depression
This study explores the differential efficacy of Spanish or English versions of a mindfulness intervention on Depression levels, using a pre test post test design and an active control condition (health education).
- Trial name
- REMAPS (NCT03545074)
- Testing
- Mindful Awareness Practices- English, Mindful Awareness Practices- Spanish, Health Education - English
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Depression, Anxiety
Online Support Groups for Depression and Anxiety
The purpose of this study is to determine the effectiveness of online support groups for anxiety and depression.
- Trial name
- NCT01149265
- Testing
- Online support group, Expressive writing
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Feasibility, Acceptability
A Digital Resilience Intervention for Emergency Medical Service Workers
Emergency medical service (EMS) workers (i.e., ambulance service providers) experience triple the risk for anxiety, depression, and posttraumatic stress disorder (PTSD) compared to the general U.S. population.
- Conditions
- Feasibility, Acceptability, Adoptability, Meaning Made
- Trial name
- NCT06861400
- Testing
- Self-Reflective Resilience-Recovery Activity Promotion Training
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Depression, Insulin Resistance
Brain Function in Depression and Insulin Resistance
The purpose of this study is to help researchers learn about how the brain responds to rewards. This study is interested in seeing how these responses differ between people who are more and less responsive to insulin in their…
- Trial name
- NCT02889211
- Testing
- Gambling Task
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Burnout, Professional, Anxiety
Storytelling Through Music to Improve Well-being Among Homeless Service Providers
Homelessness is a complex social issue and requires a dedicated workforce of helping professionals, including nurses and social workers.
- Conditions
- Burnout, Professional, Anxiety, Depression, Secondary Trauma
- Trial name
- NCT06536387
- Testing
- Storytelling Through Music
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Stress
A Stress Reduction Program for Companies
This protocol proposes a well-being program based in stress reduction program for employees of a company. objectives: To evaluate the effects of a stress reduction program with a specific orientation for workers and taught to…
- Trial name
- NCT02660307
- Testing
- PROGRESS group
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centro de estudos em Atenção Plena
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico
Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06834893)
- Testing
- Cool roof
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Healthy Participants
Targeting Large-scale Networks in Depression With Real-time fMRI (Functional Magnetic Resonance Imaging) Neurofeedback
The purpose of this study is to develop a technique called real time fMRI neurofeedback. This technique uses a functional MRI scanner, except that special software allows the researchers to measure activity in participants brain…
- Trial name
- NCT05934604
- Testing
- Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anxiety, Depression
Up-regulating Positive Affect in Emotional Disorders
The aim of this study is to assess the differential effect of two transdiagnostic treatment protocols for emotional disorders (ED) (depression and anxiety disorders) using a randomized pilot study design: a) a transdiagnostic…
- Trial name
- NCT02790398
- Testing
- Transdiagnostic treatment protocol, Transdiagnostic treatment protocol + PA regulation component
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I
Intervention Compliance, Usability
CSDM: A Trial to Improve Communication and Shared Decision Making Using a Web-Based Tool
The goal is to develop a pragmatic, scalable intervention to overcome problems with surrogate decision making in ICUs. The aim is to conduct a pilot study among surrogates and clinicians of 50 incapacitated patients at high risk…
- Conditions
- Intervention Compliance, Usability, Acceptability
- Trial name
- CSDM Pilot (NCT02955563)
- Testing
- CSDM Web-Based Tool Intervention
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Infertility, Male, Depression
Impact of Duloxetine on Male Fertility
The investigators are conducting a placebo-controlled, randomized control trial with duloxetine in healthy, fertile men not previously on any antidepressants.
- Trial name
- NCT03038867
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
Canadian Biomarker Integration Network for Depression Study
This study is a pilot to assess feasibility of the protocol in patients and controls across six participating sites. The goal is to identify biological markers (biomarkers)that can be measured at baseline or early in treatment to…
- Trial name
- CAN-BIND-1 (NCT01655706)
- Testing
- escitalopram, aripiprazole
- Where
- 6 sites in Canada
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
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