Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Depression - Major Depressive Disorder, Psychological Distress
Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms
Subclinical depression - depressive symptoms that fall below the threshold for major depressive disorder - is common in young adults and predicts later depressive episodes, yet it often goes untreated.
- Conditions
- Depression - Major Depressive Disorder, Psychological Distress, Depression / Major Depressive Disorder
- Trial name
- NDP_CCG (NCT07889908)
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Miami University
Stress, Caregiver Burden
Self-Compassion to Enhance the Well-Being of Caregivers of Children With Physical Disabilities
The goal of this clinical trial is to test the feasibility, acceptability and preliminary social/emotional well-being outcomes of a tailored, online self-compassion-based resilience course for caregivers of children with physical…
- Conditions
- Stress, Caregiver Burden, Anxiety, Depressive Symptoms
- Trial name
- NCT06271824
- Testing
- Self-Compassion Based Resilient Caregiving Course
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD)
Impact of Anxiety and Depression on Implicit and Explicit Memory Performance
This study examines the effect of anxiety and depression on memory processes, focusing on implicit and explicit memory. Implicit memory involves unconscious recall, such as recognizing familiar words without effort, while…
- Conditions
- Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Memory Bias, Implicit Memory
- Trial name
- ADEM (NCT06663423)
- Where
- Iran
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Depressive Disorder, Anxiety Disorder (Panic Disorder or GAD)
Multiple-Family Group Intervention Programming to Improve Mental Health of Adolescents Living With HIV in Ghana: An Implementation Science Approach
When young people living with HIV don't get the mental health support they need, it can lead to a lot of problems. Not only do they suffer from mental health issues, but it also makes it harder for them to stick to their HIV…
- Trial name
- NCT06701942
- Testing
- Multiple family group intervention therapy
- Volunteers
- 80 people
- Sponsor
- University of Ghana
Depression
Major Depressive Disorder (MDD)
The purpose of this study is to assess the effectiveness of systematic screening for depression in high-risk patient participants in everyday clinical practice.
- Trial name
- NCT01662817
- Testing
- Intervention, Control
- Where
- Spain
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Depression, Depressive State
A Study to Compare the Pharmacokinetic Profiles of Etravil® Tablet 10mg and Etravil® Tablet 25mg
To evaluate the pharmacokinetics of single oral dose of Amitriptyline hydrochloride film-coated tablet 10mg \& 25mg
- Conditions
- Depression, Depressive State, Enuresis
- Trial name
- DWETR (NCT01367080)
- Testing
- DWETR10, DWETR25
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dong Wha Pharmaceutical Co. Ltd.
Physical Activity Levels, Cardiovascular Fitness
Effects of Virtual Reality Exercise on Promoting Physical Activity and Health Among College Students
The purpose of this research is to examine the effectiveness of a 4-week immersive-virtual reality (VR) exercise bike intervention on college students' physiological outcomes (physical activity levels, cardiovascular fitness, and…
- Conditions
- Physical Activity Levels, Cardiovascular Fitness, Body Composition, Situational Motivation
- Trial name
- NCT06902727
- Testing
- VR-based exercise bike, Usual routine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Premenstrual Disorder, Premenstrual Dysphoric Disorder
Pilot Study of the 'Thriving With PMDs' Program
This study is testing a self-help mental health program that was designed to help people cope with the challenges of living with a premenstrual disorder.
- Trial name
- NCT06648382
- Testing
- Self-directed psychotherapy program for premenstrual disorders
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Regina
Depression, Depressive Disorders
A Study to Determine the Efficacy and Safety of 2 Doses of Org 34517 as Adjunctive Therapy in Subjects With Psychotic Major Depression (28130)(P05845)
The primary purpose of this study is to determine whether subjects with psychotic major depression benefit from adjunctive treatment with Org 34517.
- Conditions
- Depression, Depressive Disorders, Psychotic Disorders
- Trial name
- Hermes (NCT00212797)
- Testing
- Org 34517
- Volunteers
- 273 people
- Sponsor
- Merck Sharp & Dohme LLC
Major Depression
A Family-based Primary Care Intervention to Enhance Older Men's Depression Care
Despite the public health importance of clinical depression, more than 50% of depressed adults receive inadequate or no treatment, with even higher rates of under-treatment in men and minorities.
- Trial name
- NCT02143024
- Testing
- Family-based depression intervention, Usual care plus educational materials
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Davis
Borderline Personality Disorder, Borderline Personality Pathology
ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder
ADEPT is an open-label proof-of-concept study evaluating the safety and tolerability of psilocybin-assisted therapy in conjunction with Dialectical Behavior Therapy for participants with borderline personality disorder.
- Conditions
- Borderline Personality Disorder, Borderline Personality Pathology, Depressive Symptoms, Emotion Dysregulation
- Trial name
- ADEPT (NCT07833761)
- Testing
- Psilocybin, Psilocybin-Assisted Therapy With Dialectical Behavior Therapy
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Minnesota
Depression, Depressive Disorder
Web-based Self-help Intervention for Adolescents With Acute or Remitted Major Depressive Disorder
This study aims to evaluate the feasibility and effectiveness of a web-based self-help intervention in adolescents with acute or remitted major depressive disorder.
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms, Depressive Disorder, Major
- Trial name
- NCT04994470
- Testing
- Two-week web-based self-help intervention based on principles of positive psychology, Two-week web-based text messages containing fun facts
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Major Depressive Disorder
Brain Regulation of Emotions in People With Depression and Anhedonia
This study will use magnetic resonance imaging (MRI) to examine how the brain regulates emotions in healthy people and in patients who have major depression and anhedonia (loss of feeling of pleasure in things that normally give…
- Trial name
- NCT00059579
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Premenstrual Dysphoric Disorder
Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study
This research study will look at brain and symptom differences among women with severe premenstrual mood symptoms. One goal of this study is to look at the effects of taking a nasal spray containing oxytocin (a hormone made in…
- Trial name
- NCT02508103
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression
Repetitive Transcranial Magnetic Stimulation Compared or Associated With Venlafaxine for Depressive Disorder
The purpose of this study is to treat participants with a diagnosis of depressive disorder to assess the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) and venlafaxine in the treatment of depressive disorders…
- Trial name
- NCT01370304
- Testing
- active rTMS and active Venlafaxine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Depression, Unipolar, Eveningness
Effects of CBT and BLT in Youth With Unipolar Depression and Evening Chronotype
The goal of this prospective randomised controlled trial is to examine the effects of cognitive behavioural therapy and bright light therapy in youths with unipolar depression and evening chronotype.
- Trial name
- DELAY (NCT06092411)
- Testing
- Cognitive Behavioural Therapy for Depression, Bright Light Therapy
- Where
- Hong Kong
- Volunteers
- 162 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder, Rheumatoid Arthritis
Clinical Study of Escitalopram Oxalate Combined With taVNS in Depression and Concomitant Inflammatory Symptoms
This study is expected to include 90 patients with major depressive disorder and rheumatoid arthritis as study subjects.Randomly divided into 3 groups: drug + VNS stimulation group, drug + sham stimulation group and drug group…
- Trial name
- NCT04037111
- Testing
- Transcutaneous electrical vagus nerve stimulation, drug treatment
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Postpartum Depression (PPD)
A Mobile Application for Early Detection and Symptoms Trajectories of Postpartum Depression Using Ecological Momentary Assessment (EMA)
This pilot study will recruit 120 perinatal pregnant women and follow them up for 6 months. Both momentary and retrospective assessments of emotional well-being and psychosocial factors will be conducted on a mobile application.
- Trial name
- EMA For PND (NCT07382336)
- Testing
- Ecological momentary assessment and retrospective assessment
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression, Depressive Disorder, Major
Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression
Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS), a type of rTMS, is a very promising new treatment for major depression in adults and…
- Trial name
- NCT06528938
- Testing
- Theta Burst Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Depressive Disorder, Major
Peripheral Immunomarker Validation in Treatment-resistant Depression
This is a study to characterise the role of inflammatory processes in depression. There is compelling evidence that inflammation is often associated with, and can cause, depression.
- Trial name
- BIODEP (NCT02752178)
- Testing
- MA, DEP
- Where
- 5 sites in United Kingdom
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
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