Clinical trials: Depressive Disorders
Depression, Suicidal Ideation
Engaging Black Youth in Depression and Suicide Prevention Treatment Within Urban Schools
Completing evidence-based treatments for depression has been shown to be particularly problematic for Black adolescents. If Black adolescents' depression treatment needs are to be met, the engagement challenges and the factors…
- Trial name
- NCT03940508
- Testing
- Making Connections Intervention, IPT-A
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- New York University
Crisis Intervention, Suicide and Depression
Brief Online Help-seeking Barrier Reduction Intervention
Objective: Mental illness is a leading cause of disease burden; however, many barriers prevent people from seeking mental health services.
- Trial name
- NCT03633825
- Testing
- Brief help-seeking barrier reduction intervention
- Where
- United States
- Volunteers
- 39,450 people, healthy volunteers welcome
- Sponsor
- Harvard University
Anesthesia, Analgesia
The Efficacy and Safety of S-ketamine in Elective Cesarean Section
During the past years, a large number of clinical trials have investigated the use of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist racemic ketamine as an adjunct to local anaesthetics, opioids, or other…
- Conditions
- Anesthesia, Analgesia, Depression, Cesarean Section
- Trial name
- ES-CS (NCT04657107)
- Testing
- S-ketamine, normal saline
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Depressive Symptoms
The Effect of Emotional Working Memory Training on Reducing Depressive Symptoms
The purpose of this study is to test whether emotional working memory training and attention bias modification training are an effective neurobehavioral therapy to improve depressive symptoms.That is whether emotional working…
- Trial name
- NCT04346771
- Testing
- Working memory training, Positive ABMT
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hunan Normal University
Heat Stress, Pregnancy
Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat
The purpose of this study is to learn whether a simple, traditional, and balanced meal made from local foods, eaten once a day during pregnancy, can help women in rural Pakistan stay healthier in hot weather and give birth to…
- Conditions
- Heat Stress, Pregnancy, Women of Reproductive Age, Nutrition Status
- Trial name
- INSPIRE (NCT07489664)
- Testing
- Indigenous Balanced Diet Arm
- Where
- Pakistan
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Epilepsy
The Effect of Progressive Relaxation Exercises Applied to Patients With Epilepsy
Epilepsy; It is a disease characterized by sudden, repetitive, epileptic seizures that are not triggered by an identifiable event and occur as a result of abnormal and excessive electrical discharge in cortical neurons from…
- Trial name
- NCT05127499
- Testing
- progressive relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Depression
Mechanisms Underlying Antidepressant Effects of Physical Activity
It is well established that any level of physical activity can help prevent and treat depression, with more strenuous activity having a greater effect.
- Trial name
- LIFE (NCT06387732)
- Testing
- Aerobic exercise, Stretching and relaxation
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University College, London
Depression
Sertraline for the Prevention of Recurrent Postpartum Depression
This study will determine the effectiveness of taking sertraline within 24 hours of giving birth in preventing a recurrence of postpartum depression.
- Trial name
- NCT00276900
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depression Mild, Depression Moderate
Long-term Effects ReSet Your Mind - Mechanisms
See: ClinicalTrials.gov ID: NCT05402150 Relevant for this Paper: This investigation aims to evaluate the stability of the effectiveness of different two-week online interventions in a four months follow-up regarding reward…
- Trial name
- NCT06072209
- Testing
- Behavioral Activation, Mindfulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude
- Where
- Germany
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Major Depressive Disorder
IM and IV SPL026 Drug Product in Healthy Participants
The goal of this clinical trial is to test SPL026 given via injection into a muscle in healthy volunteers.
- Trial name
- NCT05644093
- Testing
- SPL026 IV, SPL026 IM
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Small Pharma Ltd
Anxiety, Depression
Evaluating the Impact of Psychotherapeutic Advertising Claims on Cannabis Purchasing
In the U.S., legal cannabis is frequently advertised as an effective treatment for mental health problems such as anxiety and depression-particularly online.
- Conditions
- Anxiety, Depression, Cannabis Use
- Trial name
- NCT07216911
- Testing
- CC, PAC, WL
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Depressive Disorder, Major
Study to Evaluate the Performance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Test Battery in Participants With Major Depressive Disorder (MDD)
The purpose of this study is to examine concurrent validity of 8 computerized tests intended for the assessment of cognitive function in participants with Major Depressive Disorder (MDD), relative to 8 corresponding and…
- Trial name
- NCT03014544
- Testing
- Computer- administered test battery, Examiner- administered test battery
- Where
- 20 sites in United States
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Depression
PET-MRI F-DOPA Activity in the Mesocorticolimbic System and Depressive Symptoms in the Prediction of Treatment Compatibility
Main objectives: Comparing levels of F-DOPA reuptake rate as an indicator for Dopamine metabolism of un-medicated Depressed patients to healthy individuals in the Mesocorticolimbic System (VTA-NAc-PFC) and assessing structural…
- Trial name
- NCT03026309
- Testing
- no intervantion
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Pregnancy Related, Burnout, Professional
The 4th Trimester Initiative: The Impact of Parental Support on Pregnant Trainee Wellbeing
The goal of this clinical trial is to determine the impact of a parental support package for new trainee mothers which focuses on mentorship, lactation, and sleep, and access to perinatal care.
- Conditions
- Pregnancy Related, Burnout, Professional, Wellness, Psychological
- Trial name
- NCT06014892
- Testing
- Snoo smart bassinet, Willow wearable breast pump, Maven Clinic on-demand perinatal consultation
- Where
- 7 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression
Effects of Saffron and Chamomile in Mild to Moderate Depression
Diabetes characterized by decreased production, or resistance to the action of insulin or both. The reduced production or action alters many important body functions namely glucose absorption and utilization in the body.
- Trial name
- NCT04935671
- Testing
- chamomile tea n saffron
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dr Saara (Ahmad) Muddasir Khan
Anhedonia in Healthy Volunteers
The Effect of an Edible Algal Extract (Ulva Lactuca) on the Component of Depression in Healthy Volunteers With Anhedonia
The effects of the seaweed extract were evaluated on the animal model equivalent of depression compared with a control group treated with the carrier (spring water) and a reference group treated with Imipramine and showed…
- Trial name
- NCT03545399
- Testing
- Ulva Lactuca
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- CEN Biotech
Depression, Low Mood
Oxford Social Movement Activation Study
For adolescents and young people particularly, there is need for better and more readily available treatments for depression and low mood.
- Conditions
- Depression, Low Mood, Depressive Disorder, Mood Disorders
- Trial name
- SOMA (NCT05963581)
- Testing
- Salsa Dancing
- Where
- United Kingdom
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Burnout Syndrome, Psychological Stress, Anxiety, and Depression Associated With Academic Pressure
Efficacy of a Gamified Blended Mindfulness Program to Reduce Burnout, Stress, and Anxiety in Nursing Students: A Randomized Controlled Trial
The primary purpose of this randomized controlled trial is to evaluate the efficacy of a 12-week gamified blended mindfulness intervention in reducing academic burnout, perceived stress, and anxiety among first-year nursing…
- Conditions
- Burnout Syndrome, Psychological Stress, Anxiety, and Depression Associated With Academic Pressure, Anxiety
- Trial name
- NCT07699835
- Testing
- Psychoeducation and Free App Recommendation, Standard Blended Mindfulness Program, Gamified Blended Mindfulness Program
- Where
- Spain
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Depression in Remission
Prucalopride and Cognition in Recovered Depression
The current study has two aims: 1. To test the effect of 5-HT4 receptor agonism on cognition (including memory, attention and cognitive control) in individuals with previous history of depression. 2.
- Trial name
- PROGRESS (NCT05220228)
- Testing
- Prucalopride
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Depression
A Study of HR071603(Ketamine Nasal Spray) in Healthy Subjects
The study is being conducted to evaluate the safety and pharmacokinetics of HR071603 in healthy subjects.
- Trial name
- NCT04108234
- Testing
- HR071603
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
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