Clinical trials: Depressive State
Respiratory Depression, Sedation
Incidence OIRD Medical and Trauma Patients
The primary objective of this prospective, blinded observational study is to correlate assessment of sedation and respiratory status with capnography and pulse oximetry monitoring in hospitalized adult medical and trauma patients…
- Trial name
- NCT03948880
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Community Health System
Sleep Phase Rhythm Disturbance, Sleep Deprivation
Are Bright Lights and Regulated Sleep Effective Treatment for Depression?
Previous data suggest some depressed patients act as if their internal biological clock is out of sync with the outside world and re-aligning their clock with the timing of sunlight lessens their depressed mood and accompanying…
- Trial name
- NCT03010488
- Testing
- Morning Light Therapy, Assigned Sleep Times, Goggles
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder (MDD)
Neurofeedback to Treat Depression - 2
This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD.
- Trial name
- NCT07159061
- Testing
- Active Closed Loop Real Time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Dementia
VRx@Home: Study to Evaluate VR-therapy for PwD Living at Home
The investigators are designing and rigorously evaluating the first Virtual Reality-therapy program for people with dementia (PwD) living at home, administered by their informal caregivers (family/friends).
- Trial name
- VRx@Home (NCT04988360)
- Testing
- HMD: Immersive VR, Tablet: Non-immersive VR
- Where
- 2 sites in Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Major Depression, PTSD
Evaluation Study of TIDES Depression Care Quality Improvement Intervention
In spite of the impact on veteran�s health status and treatment cost, depression is under-diagnosed and under-treated. The goal of this study is to learn how to implement a previously tested, effective collaborative care model…
- Trial name
- NCT00105820
- Testing
- System level depression care quality improvement
- Where
- 3 sites in United States
- Volunteers
- 750 people
- Sponsor
- US Department of Veterans Affairs
Depressive Symptoms, Anxiety Symptoms
Cognitive Behavioural Therapy for Youths With Depressive and Anxiety Symptoms in Hong Kong
The proposed study is a randomized controlled trial (RCT) that aims to examine the effectiveness of cognitive behavioural therapy in reducing depressive and anxiety symptoms for youths in Hong Kong.
- Trial name
- NCT05078424
- Testing
- Cognitive Behavioural Therapy
- Where
- Hong Kong
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Depression, Anxiety
30-Minutes of Listening to Calming Music on Attendees of a Workshop Session at a Local Conference
The goal of this clinical trial is to explore possible benefits and mechanisms through which listening to music can improve health and wellness.
- Conditions
- Depression, Anxiety, Autonomic Dysregulation
- Trial name
- NCT06557759
- Testing
- Listening to Calming Music
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Major Depressive Disorder, Depression
rTMS for MDD: 5.5cm Rule vs. F3 Targeting
The purpose of this study is to examine the effects of different treatment locations using repetitive transcranial magnetic stimulation (rTMS) to treat major depressive disorder.
- Trial name
- NCT03378570
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Nicholas Trapp
Major Depressive Disorder
Efficacy and Safety of Lu AA34893 in Patients With Major Depressive Disorder
The purpose of the study is to evaluate the efficacy, safety and tolerability of three fixed dosages of Lu AA34893 compared to placebo in the treatment of patients with Major Depressive Disorder.
- Trial name
- NCT00766870
- Testing
- Lu AA34893, Venlafaxine extended release
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- H. Lundbeck A/S
Uncertain Viability of Pregnancy, Anxiety
Psychological Impact of Predicting Early Pregnancy Outcomes in Women With Pregnancy of Uncertain Viability
This study will evaluate if providing women diagnosed with an intrauterine pregnancy of uncertain viability with a percentage likelihood of ongoing viability of their pregnancy at the time of the follow-up ultrasound, will result…
- Conditions
- Uncertain Viability of Pregnancy, Anxiety, Depression
- Trial name
- IMPROVE (NCT03264170)
- Testing
- Prediction of pregnancy outcome
- Volunteers
- 250 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Hepatitis C, Depression
Hepatitis C Translating Initiatives for Depression Into Effective Solutions
Chronic infection with hepatitis C (CHC) is a common and expensive condition, and it disproportionately affects Veterans. Treatment with antiviral therapy reduces liver disease progression and improves health related quality of…
- Trial name
- HEPTIDES (NCT01143896)
- Testing
- Depression collaborative care model
- Where
- 4 sites in United States
- Volunteers
- 309 people
- Sponsor
- VA Office of Research and Development
Depression
Binaural Beat Technology and Rhythmical Photic Stimulation
Background Many nurses must shoulder heavy workloads and often develop depressive emotions due to work stress. Previous studies pointed out that binaural beat technology (BBT) and rhythmical photic stimulation can effectively…
- Trial name
- NCT05666661
- Testing
- Sound and light therapy (BBT and FL group), Sound therapy group (BBT), Relaxing music group
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- National Cheng Kung University
Depressive Symptoms, Aging
ABSORB (Amount of Blueberries So Older Adults Reap Benefits)
This randomized, cross-over, pilot study aims to compare preliminary impact of a standard dose of blueberry powder (24 g) vs a higher dose (48 g) on the bioavailability of flavonoids and inflammatory biomarkers in older adults…
- Trial name
- NCT05937165
- Testing
- Freeze-dried Blueberry Powder
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Mental Disorders
Study of Mindfulness-based Group Treatment in Patients With Depression and Anxiety
The purpose of this study is to determine the effectiveness, with respect to symptoms and systemic inflammatory level, of mindfulness-based group treatment compared with normal treatment in patients diagnosed with minor to…
- Trial name
- NCT01476371
- Testing
- Mindfulness-based group treatment
- Volunteers
- 215 people
- Sponsor
- Lund University
Depression
Empower@Home: A Feasibility Pilot
This is an open pilot feasibility study of a novel internet-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Trial name
- NCT05243264
- Testing
- Empower@Home
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Treatment Resistant Major Depression
Establishing Mobile Transcranial Magnetic Stimulation
In this pilot study, investigators propose to design and create a portable TMS unit, in a van, and then test out delivering TMS in three different locations in South Carolina, all affiliated with MUSC and within 2-hours driving…
- Trial name
- TMS (NCT06748209)
- Testing
- Left prefrontal Transcranial Magnetic Stimulation (TMS), FDA cleared TMS for treating depression
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors
RATIONALE: Methylphenidate may decrease side effects of radiation therapy. It is not yet known if methylphenidate is effective in improving quality of life in patients with primary or metastatic brain tumors.
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Depression, Fatigue
- Trial name
- NCT00031798
- Testing
- methylphenidate hydrochloride, quality-of-life assessment, radiation therapy
- Where
- 7 sites in United States
- Sponsor
- Wake Forest University Health Sciences
Depression, Anxiety
SUpport From PEeRs to Expand Access Study - Community
Investigators will evaluate the implementation of an evidence-based, Spanish-language, digital, cognitive-behavioral therapy (dCBT) intervention (SilverCloud) in the Mission community for Latino patients with depression and/or…
- Trial name
- SUPERA (NCT07186816)
- Testing
- Behavioral: Supported dCBT, Behavioral: Unsupported dCBT
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- University of California, Berkeley
Depression
Using rTMS to Treat Depression
Repetitive Transcranial Magnetic Stimulation (rTMS) is a promising, novel, non-invasive therapy for depression. In fact, there is an FDA-approved depression protocol to stimulate the dorsolateral prefrontal cortex (dlPFC).
- Trial name
- NCT05424224
- Testing
- MagVita
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Florida International University
Depression, Postpartum, Anxiety
Examining the Effectiveness of Transdiagnostic, Internet-Delivered Cognitive Behaviour Therapy in New Mothers Experiencing Anxiety and Depression
In the proposed study, the investigators will examine the efficacy of transdiagnostic, Internet-delivered cognitive behaviour therapy (ICBT) in the treatment of postpartum anxiety and depression.
- Trial name
- NCT04012580
- Testing
- Therapist-assisted ICBT
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Regina
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