Clinical trials: Development Disorders
Behavior and Behavior Mechanisms
Translational Research to Inform Interventions for Challenging Behavior
This project is meant to identify relations between the reinforcement histories of 80 adults with intellectual and developmental disabilities (IDD) and the prevalence of extinction bursts.
- Trial name
- NCT04842500
- Testing
- Demand Informed Moderator Analysis
- Where
- 5 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH)
Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor Hypomineralization
The main questions this study aims to answer are: Does computer-controlled local anesthesia cause less pain and anxiety than conventional local anesthesia in children with molar-incisor hypomineralization (MIH)? Is there a…
- Conditions
- Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH), Computer-Controlled Local Anesthesia
- Trial name
- NCT07733011
- Testing
- Computer-Controlled Local Anesthesia, Conventional Local Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Marmara University
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Weifang (PKUBC-WF)
The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- NCT06234332
- Testing
- No Interventions
- Where
- China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Peking University
Developmental Disabilities
Child Development and Genetic Biomarkers(II): Gene Verification and Data Integration
The aims of the study include (1) identifying genes associated with child development and developmental delay in Taiwan (2) comparing the differences and similarities between genetic biomarkers of development and developmental…
- Trial name
- NCT06532721
- Where
- Taiwan
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn
Amniotic Fluid & the Preterm Gut
Background: Necrotizing enterocolitis (NEC) and sepsis in preterm infants have been linked to intestinal immaturity and preclinical gut microbiota alterations.
- Conditions
- Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn, Necrotizing Enterocolitis of Newborn, Neonatal Sepsis, Early-Onset
- Trial name
- AMFIBIE (NCT07152106)
- Where
- 2 sites in Netherlands
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Spondyloarthritis, Ruminococcus Gnavus
The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis
The primary objective of this case-control study aims to explore the role of bacterium Ruminococcus gnavus (R. gnavus) with intestinal biopsy and faecal sampling in the initiation and the development of spondyloarthritis (SPA) in…
- Trial name
- RUMINOSPA (NCT04853212)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder
Measuring Brain Inflammation in Autism
Autism spectrum disorders (ASD) are highly disabling, persistent neurodevelopmental disorders. There are no available treatments for core symptoms of ASD or biologically-based clinical biomarkers.
- Trial name
- NCT03117530
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Autism Spectrum Disorder
Investigation of the HDAC4 Copy Number Variation and Its Effect on Gene and Protein Expression in Patients With ASD
Specific Aims of this study: 1. To understand the distribution of HDAC4 CNV in the families of the ASD patients with HDAC4 CNV; 2. To perform the analysis of gene expression; 3.
- Trial name
- NCT03670381
- Testing
- Psychiatric diagnosis
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Autistic Disorder
Characterisation of Circadian Rhythm in Autistic Spectrum Disorder
Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors.
- Trial name
- NCT01984944
- Testing
- Autistic functional exploration, Control functional exploration
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Growth Hormone Deficiency
Growth Hormone's Effect on the Cardiovascular System
To evaluate specific markers of cardiovascular risk before and after growth hormone replacement therapy in a population of growth hormone deficient adults, as compared to an age, gender, and BMI-matched healthy population.
- Trial name
- NCT00397319
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Autism Spectrum Disorder, Patient Engagement
Testing Design Thinking Methodology to Engage Hispanic and Latino Families of Autistic Children in Research.
The goal of this study is to compare two methods of engagement in research that include autistic individuals, Hispanic and Latino parents of autistic children, occupational therapy clinicians, teachers, and to use the information…
- Trial name
- NCT06111092
- Testing
- Design Thinking, Focus Groups
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Bone Density Increased
Radiographic Assessment of Bone Dimension Around Immediate Implants With FDBA and I-PRF vs FDBA Alone
The present study is a human, prospective, parallel, randomised controlled clinical trial conducted for radiographic assessment of bone dimension around immediate implants with FDBA and I-PRF vs FDBA Alone The trial is in…
- Trial name
- NCT06522321
- Testing
- i-PRF and FDBA
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Atopic Dermatitis, Eczema Herpeticum
Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic Dermatitis
Atopic Dermatitis (AD), also known as eczema, is a skin disease that causes the skin to be hot, dry and scaly, and have severe itching. There are different kinds of eczema.
- Trial name
- NCT00438022
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fertility Disorders
Data Collection Protocol for the Development of CHLOE-OQ, an AI Model for Assessing Oocytes Quality.
This data collection protocol is aimed to allow the reliable and robust development (training, verification, and validations) of CHLOE technology-based applications as well as improve the machine learning stage of released…
- Trial name
- NCT06928337
- Testing
- AI evaluation of oocytes.
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fairtility
HIV/AIDS
PrEP Communication Intervention for Female Clients of a Needle Exchange
This study will identify perceptions of PrEP in women who inject drugs (WWIDs) and develop and pilot test a targeted intervention that will be embedded in a large, urban syringe exchange program through an extensive formative…
- Trial name
- NCT03541642
- Testing
- Enhanced Intervention, Basic Intervention
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Temple University
Parkinson Disease
Cognitive Testing Online in Parkinson's Disease
This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research.
- Trial name
- NCT05025254
- Testing
- Neurocognitive testing
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- McGill University
Macular Degeneration, Age-Related Macular Degeneration
Development of a Device to Measure Dark Adaptation
Age Related Macular Disease (AMD) is easily the leading cause of blindness in older people in developed countries. It affects between 30 and 50 million individuals worldwide, with around 30% of the over 65's showing early signs…
- Trial name
- NCT02090751
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manchester
HIV Infections
Development of a New HIV Vaccine
The purpose of the study is to determine the safety of a new HIV vaccine and to evaluate the immune response to the vaccine. Only some HIV genes are used to make the vaccine and therefore the vaccine cannot itself cause HIV or…
- Trial name
- NCT00051922
- Testing
- PolyEnv1
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Preterm Infant
Development, ADL, Participation, and Quality of Life in Preterm Infants: Longitudinal Research
The three fundamental goals of early rehabilitation for preterm infant after leaving NICU are: optimizing function within each child's prognostic potential, preventing the development of secondary conditions that impact life-long…
- Trial name
- NCT06532695
- Testing
- No intervention will be provided.
- Where
- Taiwan
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Lung Cancer
OncoSweep Cancer Spotlight and Spectrum Product Line
CONQUER cancer study: To collect blood samples from cancer and non-cancer participants for development and validation of the 'OncoSweep Cancer Spotlight and Spectrum Product Line'
- Trial name
- NCT06261294
- Testing
- OncoSweep Lung Spotligh
- Where
- Taiwan
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Pharus Taiwan, Inc.
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