Clinical trials: Development Disorders
Asthma
LIving BEtteR With asThma - Intervention Development Study
Approximately 330 million people in the world are living with asthma and 3-10% of them has difficult asthma that is challenging to control even with maximum doses of pharmacological treatment.
- Trial name
- LIBERTY-ID (NCT06159803)
- Testing
- Qualitative Interview
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Traumatic Brain Injury
Development of Quality of Life Tool for TBI
Objectives: The ultimate goal of this research program is to promote seamless, comprehensive care for Operation Enduring Freedom/ Operation Iraqi Freedom (OEF/OIF) veterans.
- Trial name
- TBIQOL (NCT00714428)
- Where
- 4 sites in United States
- Volunteers
- 485 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Neurodevelopmental Disorders, Autism Spectrum Disorder
A Game-based Neurodevelopmental Assessment for Young Children
The aim of this study is to evaluate a novel tablet game-based neurodevelopmental assessment tool for young children aged 3 to 8 years old.
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Dyslexia
- Trial name
- BRIGHTEN (NCT05780853)
- Testing
- Tablet Game-based Assessment - YARN assessment service, Adaptive Behavior Assessment System, Third Edition (ABAS-3), Demographic questionnaire
- Where
- United Kingdom
- Volunteers
- 590 people, healthy volunteers welcome
- Sponsor
- Brightlobe Limited
Autism Spectrum Disorder
Modulation of the Activity of the Cerebellum in Autism (MACA)
Research on the involvement of the cerebellum in social understanding behavior and the mentalizing brain system has just begun. Knowledge about the neurobiology of social understanding is important for understanding the ways to…
- Trial name
- MACA (NCT05781412)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beatriz Catoira
Overweight, Physical Activity
Early Obesity Intervention Program Within GECKO Drenthe; a Randomized Controlled Trial
The purpose of this study is to investigate whether stimulating physical activity during the first year of life influences growth and body composition, and stimulates motor activity and motor development
- Trial name
- NCT01127412
- Testing
- Physical activity stimulating program
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Stem Cell Transplantation
Autologous Bone Marrow Stem Cell Therapy Combined With Psychological Therapy and Rehabilitation for Autism
The aim of this study was to evaluate the safety and effectiveness of autologous bone marrow mononuclear stem cells combined with Psychological Therapy and Rehabilitation for Autism children
- Trial name
- ASPRA (NCT03225651)
- Testing
- Stem cell transplantation, Psychological therapy and Rehabilitation
- Where
- Vietnam
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Obesity, Childhood, Nutrition
Nutrition Recommendation Intervention trialS in Children's Healthcare
NuRISH is a suite of clinical trials for children from low-income families which will determine whether primary healthcare prescription for: 1) Optimal breastfeeding with support from a mobile lactation consultant vs.
- Conditions
- Obesity, Childhood, Nutrition, Health Risk Behaviors, Breastfeeding
- Trial name
- NuRISH (NCT05477628)
- Testing
- Childcare Navigator, Lactation Consultant, Lactation Consultant Support and Childcare Navigator Support
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Infant, Premature, Diseases
Effect of Tactile-Kinesthetic Stimulation on Preterm Neonates
An interventional study to evaluate the effect of tactile-kinesthetic stimulation (TKS) on growth, neurobehavior and development among preterm neonates in the neonatal unit of Dr. Cipto Mangunkusumo Hospital.
- Trial name
- NCT04807088
- Testing
- Tactile-kinesthetic Stimulation
- Where
- Indonesia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Anterior Segment Diseases
Multimodal Deep Learning Model for Multi-task Diagnosis and Triage Suggestions of Ophthalmic Diseases
Accurate and comprehensive interpretation of anterior segment diseases from slit-lamp and smartphone photographs remains a clinical challenge due to the limited specificity and structure of existing Artificial Intelligence tools.
- Trial name
- NCT07447973
- Testing
- Multimodal Vision-language Model Diagnosis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Chronic Obstructive Pulmonary Disease
Responses Induced by Smoking in Individuals Being Susceptible and Non-Susceptible for Development of COPD
COPD is ranked number 3 by the WHO list of important diseases worldwide and is the only disease with increasing mortality. The pathogenesis of cigarette smoke-induced COPD is obscure, therefore more insight is needed to design…
- Trial name
- NCT00807469
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Top Institute Pharma
Autistic Disorder
Associative Memory in Autism Spectrum Disorder
The aim of this study is to investigate the neural substrates of associative memory in Autism Spectrum Disorder using both behavioural and EEG assessments.
- Trial name
- MEM-TA (NCT02265094)
- Testing
- Electroencephalography, Neuropsychological assessment
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Brain Metastases, Brain Metastases, Adult
Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment
The purpose of this study is to develop and test a new magnetic resonance imaging (MRI) technique to see if it can be used to tell the difference between tumor growth from worsening of cancer and growth from the effects of…
- Conditions
- Brain Metastases, Brain Metastases, Adult, Metastatic Brain Tumor, Metastatic Brain Cancer
- Trial name
- NCT05559853
- Testing
- CEST-MRF
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Parkinson Disease, Accidental Fall
Development and Evaluation of a Guide to Help People With Parkinson's and Their Caregivers to Self-manage Falling
This study will investigate whether it is possible, through the development and evaluation of a self-management guide, to improve health related quality of life and concern of falling in people with Parkinson's disease who fall…
- Trial name
- NCT03111472
- Testing
- Self-management guide for people with Parkinson's who fall and their informal caregivers
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Oppositional Defiant Disorder, Conduct Disorder
Resources to Enhance the Adjustment of Children (REACH)
This continuation study evaluates the long-term outcomes of multimodal, modular interventions with early-onset behavior disordered children and innovative methods to promote the maintenance and extension of treatment effects…
- Conditions
- Oppositional Defiant Disorder, Conduct Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- REACH (NCT00820001)
- Testing
- Booster Treatment, No-Booster, No intervention
- Where
- 2 sites in United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Autism, Pain
Pain in Adults With Autism Spectrum Disorder
Pain insensibility is often described in people with autism. The aim of this study is to test the pain perception in adults with autistic spectrum disorder without intellectual disability.
- Trial name
- DOUPA (NCT02277756)
- Testing
- thermode
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Autism Spectrum Disorder
Age-related Changes in Myeloarchitectonics Across Adulthood in Autism Spectrum Disorder
There is increasing awareness in the Autism Spectrum Disorder (ASD) research field about the deficit of knowledge with regard to the neurobiological, cognitive, and behavioral changes that occur in adults with ASD across the…
- Trial name
- NCT04108312
- Testing
- Anatomical MRI Scan
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Skin Cancer
TLR4 Polymorphisms and Risk of Skin Cancer
Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4 (TLR4) in particular, appears to play a role in susceptibility to cancer.
- Trial name
- NCT03122366
- Testing
- Detection of single nucleotide polymorphisms (SNP)
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Molar Incisor Hypomineralisation
Articaine 4% Versus Lidocaine 2% for Local Anesthesia of MIH-affected Maxillary Molars
Comparison of injection pain with lidocaine and articaine. Comparison of the efficacy of lidocaine and articaine during treatment of MIH- maxillary molars.
- Trial name
- NCT05585112
- Testing
- Lidocaine 2%, Articaine 4%
- Where
- Syria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Latakia University
Acromegaly, Growth Hormone Deficiency
Peripheral Metabolic Effects of Somatostatin
The aim of this study is to investigate peripheral effects of Somatostatin on glucose metabolism and growth hormone (GH) signalling in healthy men. Eight subjects will be enrolled.
- Conditions
- Acromegaly, Growth Hormone Deficiency, Diabetes
- Trial name
- NCT01062529
- Testing
- Somatostatin
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Neurodevelopmental Disorder, Bilateral Inguinal Hernia
Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
This is a prospective randomized controlled trial comparing dexmedetomidine sedation with caudal anaesthesia, and general sevoflurane anaesthesia with caudal anaesthesia for inguinal herniotomies in neonates and infants below 3…
- Trial name
- DEGA (NCT02559102)
- Testing
- Dexmedetomidine sedation, General sevoflurane anaesthesia, Caudal anaesthesia
- Where
- Singapore
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
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